University of Wisconsin
School of Medicine and Public Health

Biology of Aging

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BOA

The cost of Alzheimer's Disease therapy or drug development is significant, often taking up to 13 years from pre-clinical study to approval by the FDA.  Biology of Aging research focuses on the front-end target through pre-clinical studies.  With the aim to identify the disease biology and determine efficacy, this is a lengthy process that takes time and understanding across a range of disciplines.  Investigating what causes delayed aging allows researchers to identify molecular mechanisms that potentially link to the age-associated illnesses.  Caloric restriction is researched for its ability to off-set age-associated illnesses through molecular studies on postmitotic tissues.  Neurodegenerative diseases are researched through a combination of biochemical, cellular, molecular, and genetic approaches in in vitro, ex vivo and in vivo models.  Researching the effects of reproductive hormones throughout the lifecycle provides information on how they become dysregulated later in life and how they drive senescence via altered cell cycle signaling.