Understanding Dementia Risk Factors

Clinical research in Alzheimer's disease investigates the impact of modifiable and non-modifiable risk factors for dementia. This helps determine when dementia symptoms might first appear and how fast dementia may progress from mild to moderate to severe cognitive impairment.

Dr. Nicole Rogus-Pulia in clinic.

Additional Studies

ADRC Clinical Core Study

People who join the Clinical Core attend a yearly or every other year visit with a study partner. Study procedures include memory and thinking ability evaluations, physical examination, blood collection, lumbar puncture, and brain scans. They also agree to be contacted about other ADRC-affiliated studies.

Population and age group: People with Alzheimer's disease, people with mild cognitive impairment (MCI), People age 45-65 with or without a parental history of AD.

Principal Investigator: Sanjay Asthana, MD

Contact: TBD


The ARMADA study investigates a new set of measures on the iPad to determine if they can detect early signs of cognitive decline. This study involves tests of thinking abilities, emotions, and sensory and motor functions.

Population and age group: Individuals with a diagnosis of Alzheimer's Disease or African Americans with Mild Cognitive Impairment, who are 65 years old or older. 

Principal Investigator: Cindy Carlsson, MD

Contact: Colleen Mellert 


The observational arm of the A4 study. The study involves six in-person visits spread over 18 months at the William S. Middleton Memorial Veterans Hospital.

Population and age group: VA-eligible Veterans aged 50-75 years without a diagnosis of a memory disorder. 

Principal Investigator: Cindy Carlsson, MD

Contact: TBD