Barbara Bendlin, PhD | Brain and Cognitive Changes in Normal and Pathological Aging
Barbara Bendlin, PhD, is a federally funded investigator who studies the interplay of factors that contribute to healthy or pathological brain aging. These include the effect of mid-life metabolic disorders (obesity and insulin resistance), sleep, diet, and microbial influences.
How Risk Factors for Alzheimer’s Disease Affect the Brain
Understanding early brain changes in people who may go on to develop cognitive decline is expected to lead to earlier diagnosis, prevention, and the development of new therapies for Alzheimer’s disease. Dr. Bendlin's research team uses cognitive testing, MRI, PET, and CSF analysis to determine how risk factors for Alzheimer’s affect the brain, particularly in mid-life.
The team is currently focused on characterizing the early effects of Alzheimer’s disease on brain myelin and axons, and determining the role of preclinical inflammation in cell and dendritic damage.