Tobey Betthauser, PhD: The Time Course of Alzheimer’s Disease and Related Disorders
Tobey Betthauser, PhD, leads research to better understand the sequence of events that occur in neurodegenerative diseases, with a focus on Alzheimer’s disease.
Biomarkers for AD Detection and Progression
In Alzheimer’s disease, characteristic pathologic lesions form one to two decades prior to the onset of cognitive symptoms, during a phase referred to as “preclinical AD.” Dr. Betthauser’s current work includes developing and evaluating novel approaches to characterizing the time course of amyloid accumulation and other pathophysiologic processes in AD using biomarkers for these biological targets.
Dr. Betthauser's team also investigates the sensitivity and specificity of in vivo biomarkers for their molecular targets with postmortem confirmation of pathologic entities.
This combined research is designed to better the understanding of the clinical and research utility and limitations of fluid and imaging biomarkers to detect pathophysiologic processes during life, and to better understand how these pathologic processes influence symptoms of disease.
- Longitudinal biomarker modeling
- Neuropathological validation of in vivo biomarker