The Allergy, Pulmonary and Critical Care Medicine Division at the UW School of Medicine and Public Health has ongoing basic and clinical research programs in abroad spectrum of disciplines, including acute lung injury, asthma and allergic diseases, cystic fibrosis, pulmonary hypertension, interstitial lung diseases, lung cancer and interventional pulmonology.
Major research interests include:
Acute lung injury.
Investigators use unique mouse models to identify the processes that govern acute lung injury and its resolution. This research incorporates state-of-the-art computational and pathway-focused network analysis of lung proteomics and transcriptomics data to identify cells and pathways that are potential targets for lung injury.
Basic studies of the role of inflammatory mediators in the pathogenesis of asthma are complemented with clinical research to identify more effective therapeutic strategies.
Sleep disordered breathing.
The causes and consequences of sleep apnea during chronic lung disease are actively being investigated. Additionally, cardiovascular consequences of sleep apnea are being tested.
The role of inflammatory mediators is investigated in the pathogenesis of cystic fibrosis, graft rejection following lung transplantation, and aging. Clinical trials assess innovative approaches to modifying the inflammatory response to reduce lung injury.
Clinical studies using the extensive critical care database have been performed to investigate the impact of patient care processes on outcomes and costs. Interventions and follow-up assessments of efficacy are performed to assess new ways to delivery patient care in the intensive care unit. We also have a number of QI projects using Point of Care Ultrasound.
Innovative diagnostic strategies for the early detection of lung cancer have been developed and tested.