The Allergy, Pulmonary and Critical Care Medicine Division at the UW School of Medicine and Public Health has ongoing basic and clinical research programs in abroad spectrum of disciplines, including acute lung injury, asthma and allergic diseases, cystic fibrosis, pulmonary hypertension, interstitial lung diseases, lung cancer and interventional pulmonology.
Major research interests include:
Acute lung injury.
Investigators use unique mouse models to identify the processes that govern acute lung injury and its resolution. This research incorporates state-of-the-art computational and pathway-focused network analysis of lung proteomics and transcriptomics data to identify cells and pathways that are potential targets for lung injury.
We conduct basic research on the role of inflammatory mediators in the pathogenesis of asthma, and complement this work with clinical studies to identify more effective therapeutic strategies.
Sleep disordered breathing.
Researchers are actively investigating the causes and consequences of sleep apnea during chronic lung disease.
Researchers are investigating the role of inflammatory mediators in the pathogenesis of cystic fibrosis, graft rejection following lung transplantation, and aging. Clinical trials assess innovative approaches to modifying the inflammatory response to reduce lung injury.
Investigators work to better understand long-term outcomes among survivors of critical illness, particularly cognitive and other functional outcomes among older persons. They are also developing a process model to improve desiision making about stopping or prolonging the use of life support in patients with critical illness.
We have developed and tested innovative diagnostic strategies for the early detection of lung cancer.