University of Wisconsin
School of Medicine and Public Health

Research Training in Hematology

University of Wisconsin-Madison
Kirschstein National Research Service Award
(NIH National Heart, Lung, and Blood Institute Grant: T32 HL07899)

Trainee Publications:

Pre-Doctoral Trainees

Mitchell, Josh
Mentor: Mosher, Deane
Years in RTH T32 Programs: 2019 - present

Yada, Ravi Chandra
Mentor: Beebe, David
Years in RTH T32 Programs: 2020 - Present

Post-Doctoral Trainees:

Sethakorn, Nan
Mentor: Lang, Josh
Years in RTH T32 Programs: 2019- Present

Rodenbach, Rachel
Mentor: Campbell, Toby
Years in RTH T32 Programs: 2020-Present

Robertson, Tanner Ford
Mentor: Huttenlocher, Anna
Years in T32 Programs: 2020-Present

Click here to jump to Past Post-doctoral Trainees

Past Pre-doctoral Trainees:

Hoffmann, Brian
Mentor: Mosher, Deane
Years in RTH T32 Program: 2006 & 2009

Recent Publications:

Choudhury A, Rosas Valdez R., Johnson R, Hoffmann B, Perez-Ponce de Leon G. 92007). The phylogenetic position of Allocreadiidae (Trematoda: Digenea) from partial sequences of the 18S and 28S ribosomal RNA genes. J Parasitol, 2007. 93(1): p. 192-6. PMID: 17436963

Xu J, Maurer L, Hoffmann B, Annis D, Mosher D, (2010) iso-DGR sequences do not mediate binding of fibronectin N-terminal modules to adherent fibronectin-null fibroblasts. J Biol Chem, 2010. 285(12): p. 8563-71. PMID: 20097751 PMCID: PMC2838278, PMCID: PMC2838278

Hoffmann B, Annis D, Mosher D. (2011) Reactivity of the N-terminal region of fibronectin protein to transglutaminase 2 and factor XIIIa. J Biol Chem. 2011 Sep 16; 286(37): 32220-30. PMID: 21757696 PMCID: PMC3173148

Hoffmann BR, Liu Y, Mosher DF. (2012) Modification of EGF-like module 1 of thrombospondin-1, an animal extracellular protein, by O-linked N-acetylglucosamine. PLoS One. 2012;7(3):e32762. doi: 10.1371/journal.pone.0032762. Epub 2012 Mar 5. PMID: 22403705 PMCID: PMC3293841

Hoffmann BR, El-Mansy MF, Sem DS, Greene AS. (2012) Chemical proteomics-based analysis of off-target binding profiles for rosiglitazone and pioglitazone: clues for assessing potential for cardiotoxicity.J Med Chem. 2012 Oct 11;55(19):8260-71. doi: 10.1021/jm301204r. Epub 2012 Sep 28.PMID:22970990 PMCID: PMC4113394

Kaczorowski CC, Stodola TJ, Hoffmann BR, Prisco AR, Liu PY, Didier DN, Karcher JR, Liang M, Jacob HJ, Greene AS. (2013) Targeting the endothelial progenitor cell surface proteome to identify novel mechanisms that mediate angiogenic efficacy in a rodent model of vascular disease. Physiol Genomics. 2013 Nov 1;45(21):999-1011. doi: 10.1152/physiolgenomics.00097.2013. Epub 2013 Sep 10. PMID: 24022221

Hoffmann BR, Wagner JR, Prisco AR, Janiak A, Greene AS. (2013) Vascular endothelial growth factor-A signaling in bone marrow-derived endothelial progenitor cells exposed to hypoxic stress. Physiol Genomics. 2013 Nov 1;45(21):1021-34. doi: 10.1152/physiolgenomics.00070.2013. Epub 2013 Sep 10.PMID:24022223

Prisco AR, Bukowy JD, Hoffmann BR, Karcher JR, Exner EC, Greene AS. (2014) Automated quantification reveals hyperglycemia inhibits endothelial angiogenic function. PLoS One. 2014 Apr 9;9(4):e94599. doi: 10.1371/journal.pone.0094599. eCollection 2014. PMID: 24718615 PMCID: 3981811

Karcher JR, Hoffmann BR, Liu P, Liu Y, Liang M, Greene AS. (2015) Genome-wide epigenetic and proteomic analysis reveals altered Notch signaling in EPC dysfunction. Physiol Rep. 2015 Apr;3(4). PMID: 25921777 PMCID: PMC4425964

Gavala, Monica
Mentor: Bertics, Paul
Years in RTH T32 Program: 2006-2008

Recent Publications:

Guo L-W, Hajipour AR, Gavala ML, Arbabian M, Martemyanov KA, Arshavsky VY, Ruoho AE. Sulfhydryl-Reactive, Cleavable, and Radioiodinatable Benzophenone Photoprobes for Study of Protein-Protein Interaction. Bioconjug Chem. 2005 May-Jun;16(3):685-93. PMID: 15898738

Guerra AN, Gavala ML, Chung HS, Bertics PJ. Nucleotide Receptor Signalling and the Generation of Reactive Oxygen Species. Purinergic Signal. 2007 Mar;3(1-2):39-51. Epub 2007 Jan 6. PMID: 17448897 PMCID: PMC2096761

Gavala ML, Pfeiffer ZA, Bertics PJ. The Nucleotide Receptor P2RX7 Mediates ATP-Induced CREB Activation in Human and Murine Monocytic Cells. J Leukoc Biol. 2008 Oct;84(4):1159-71. Epub 2008 Jul 14. PMID: 18625910 PMCID: PMC2538603

Pfeiffer ZA, Guerra A, Hill LM, Gavala ML, Prabhu U, Aga M, Hall DJ, Bertics PJ. Nucleotide Receptor Signaling in Murine Macrophages Is Linked to Reactive Oxygen Species Generation. 2007 Free Radical Biology & Medicine 42(10):1506-1516 PMID:18404417 PMCID: PMC1934340

Lenertz LY, Gavala ML, Hill LM, Bertics PJ. Cell signaling via the P2X(7) nucleotide receptor: linkage to ROS production, gene transcription, and receptor trafficking. Purinergic Signal. 2009 Jun;5(2):175-87. Epub 2009 Mar 5. PMID: 19263245 PMCID:PMC2686823

Lenertz LY, Wang Z, Guadarrama A, Hill LM, Gavala ML, Bertics PJ. Mutation of putative N-linked glycosylation sites on the human nucleotide receptor P2X7 reveals a key residue important for receptor function. 2010 Biochemistry 49: 4611-4619.PMID: 20450227 PMCID: PMC2895974

Hill LM, Gavala ML, Lenertz LY, Bertics PJ. Extracellular ATP may contribute to tissue repair by rapidly stimulating purinergic receptor X7-dependent vascular endothelial growth factor release from primary human monocytes. J Immunol. 2010 Sep 1;185(5):3028-34. Epub 2010 Jul 28. PMID: 20668222 PMCID: PMC3156583

Gavala ML, Hill LM, Lenertz LY, Karta M, Bertics PJ. Activation of the transcription factor FosB/activating protein-1 (AP-1) is a prominent downstream signal of the extracellular nucleotide receptor P2RX7 in monocytic and osteoblastic cells. J Biol Chem. 2010 Oct 29;285(44):34288-98. Epub 2010 Sep 2. PMID: 20813842 PMCID: PMC2962527

Lenertz LY, Gavala ML, Zhu Y, Bertics PJ. Transcriptional Control Mechanisms Associated with the Nucleotide Receptor P2X7, a Critical Regulator of Immunologic, Osteogenic and Neurologic Functions. Immunol Res. 2011 May;50(1):22-38. PMID: 21298493 PMCID: PMC3203638

Gavala ML, Bertics PJ, Gern JE. Rhinoviruses, Allergic Inflammation, and Asthma. Immunol Rev. 2011 Jul;242(1):69-90. doi: 10.1111/j.1600-065X.2011.01031.x. Review. PMID: 21682739 PMCID: PMC3119863

Gavala ML, Kelly EA, Esnault S, Kukreja S, Evans MD, Bertics PJ, Chupp GL, Jarjour NN. Segmental allergen challenge enhances chitinase activity and levels of CCL18 in mild atopic asthma Clin Exp Allergy. 2013 Feb;43(2):187-97. doi: 10.1111/cea.12032. PMID: 23331560 PMCID: PMC3623278

Gavala ML, Bashir H, Gern JE. Virus/allergen interactions in asthma. Curr Allergy Asthma Rep. 2013 Jun;13(3):298-307. doi: 10.1007/s11882-013-0344-1. Review. PMID: 23475539 PMCID: PMC3662249

Gavala ML, Liu YP, Lenertz LY, Zeng L, Blanchette JB, Guadarrama AG, Denlinger LC, Bertics PJ, Smith JA. Nucleotide receptor P2RX7 stimulation enhances LPS-induced interferon-β production in murine macrophages. J Leukoc Biol. 2013 Oct;94(4):759-68. doi: 10.1189/jlb.0712351. Epub 2013 Aug 2.PMID:23911869 PMCID: PMC3774844

Karta MR, Gavala ML, Curran CS, Wickert LE, Keely PJ, Gern JE, Bertics PJ. Lipopolysaccharide Modulates Rhinovirus-Induced Chemokine Secretion in Monocytes and Macrophages. Am J Respir Cell Mol Biol. 2014 Feb 5. [Epub ahead of print] PMID: 24498897 PMCID: PMC4091859

Karta MR, Wickert LE, Curran CS, Gavala ML, Denlinger LC, Gern JE, Bertics PJ. Allergen challenge in vivo alters rhinovirus-induced chemokine secretion from human airway macrophages. J Allergy Clin Immunol. 2014 Apr;133(4):1227-30. doi: 10.1016/j.jaci.2014.01.003. Epub 2014 Feb 14. No abstract available.PMID:24529411 PMCID: PMC3973023

Maurer, Lisa M
Mentor: Mosher, Deane
Years in RTH T32 Program: 2007-2008

Recent Publications:

Maurer LM, Yohannes E, Bondurant SS, Radmacher M, Slonczewski JL. pH regulates genes for flagellar motility, catabolism, and oxidative stress in Escherichia coli K-12. J Bacteriol 187:304-19, 2005. PMID: 15601715 PMCID: PMC538838.

Xu J, Maurer LM, Hoffmann BR, Annis DS, Mosher DF. 2010. iso-DGR sequences do not mediate binding of fibronectin N-terminal modules to adherent fibronectin-null fibroblasts. J Biol Chem. 285(12):8563-8571. PMID: 20097751  PMCID: PMC2838278

Maurer LM, Tomasini-Johansson BR, Mosher DF. 2010. Emerging roles of fibronectin in thrombosis. Thromb Res. 125(4):287-291. PMID: 20116835 PMCID: PMC2877496.

Maurer LM, Tomasini-Johansson BR, Ma W, Annis DS, Eickstaedt NL, Ensenberger MG, Satyshur KA, Mosher DF. 2010. Extended binding site on fibronectin for the functional upstream domain of protein F1 of Streptococcus pyogenes. J Biol Chem. 285(33):41087-41099. PMID: 20947497 PMCID: PMC3003407.

Maurer LM, Ma W, Eickstaedt NL, Johnson IA, Tomasini-Johansson BR, Annis DS, Mosher DF. 2012. Ligation of the fibrin-binding domain by b-Strand Addition is sufficient for expansion of soluble fibronectin. J Biol Chem. 287(16):13303-13312. PMID: 22351755  PMCID: PMC3339936.

Maurer LM, Annis DS, Mosher DF. 2012. IGD motifs, which are required for migration stimulatory activity of fibronectintype I modules, do not mediate binding in matrix assembly. PLoS ONE. 7(2):e30615. PMID: 22355321 PMCID: PMC3280265

Moussavi-Harami SF, Annis DS, Ma W, Berry SM, Coughlin EE, Strotman LN, Maurer LM, Westphall MS, Coon JJ, Mosher DF, Beebe DJ. Characterization of molecules binding to the 70K N-terminal region of fibronectin by IFAST purification coupled with mass spectrometry.J Proteome Res. 2013 Jul 5;12(7):3393-404. doi: 10.1021/pr400225p. Epub 2013 Jun 21.PMID:23750785 PMCID: PMC3832424

Harris G, Ma W, Maurer LM, Potts JR, Mosher DF. Borrelia burgdorferi Protein BBK32 Binds to Soluble Fibronectin via the N-terminal 70-kDa Region, Causing Fibronectin to Undergo Conformational Extension. J Biol Chem. 2014 Aug 8;289(32):22490-9. doi: 10.1074/jbc.M114.578419. Epub 2014 Jun 24. PMID:24962582 PMCID: PMC4139255

Wernimont, Sara
Mentor: Huttenlocher, Anna
Years in RTH T32 Program: 2006-2007

Recent Publications:

Wernimont SA, Cortesio CL, Simonson WT, Huttenlocher A. 2008. Adhesions ring: a structural comparison between podosomes and the immune synapse (review). Eur J Cell Biol 87:507-15. PMID: 18343530 PMCID: PMC2570187

Wang X, Chen X, Rodenkirch L, Simonson WT, Wernimont SA, Ndonye RM, Veerapen N, Gibson D, Howell AR, Besra GS, Painter GF, Huttenlocher A, Gumperz JE. 2008. Natural Killer T-cell autoreactivity leads to a specialized activation state. Blood 112:4128-38. PMID: 18779390 PMCID: PMC2581981

Schartner JM, Simonson WT, Wernimont SA, Nettenstrom LM, Huttelocher A, Seroogy CM. 2009. Gene related to anergy in lymphocytes (GRAIL) expression in CD4+ T cells impairs actin cytoskeletal organization during t cell antigen presenting cell interaction. J Biol Chem 284:34674-81. PMID:19833735 PMCID: PMC2787330

Wiemer AJ, Lokuta MA, Surfus JC, Wernimont SA, Huttenlocher A. 2010. Calpain Inhibition impairs TNF-alpha-mediated neutrophil adhesion, arrest and oxidative burst. Mol Immunol 47:894-902. PMID: 19889458 PMCID: PMC2814964

Wernimont SA, Simonson WT, Seroogy CM, Greer PA, Huttenlocher A. 2010. Calpain 4 is not necessary for LFA-1-mediated function in CD4+ T cells. PLoS One. 2010 May 7;5(5):e10513. PMID: 20479866 PMCID: PMC2866319

Cortesio CL, Cooper KM, Wernimont SA, Kastner DL, Huttenlocher, A. 2010. Impaired podosome formation and invasive migration of macrophages from patients with a PSTPIP1 mutation and PAPA syndrome. Arthritis Rheum. 2010 Aug;62(8):2556-8. PMID:20506269 PMCID: PMC2921034

Wernimont SA, Legate KR, Simonson WTN, Fassler R and Huttenlocher A. 2010. PIPKI gamma 90 negatively regulates LFA-1-mediated adhesion and activation in antigen-induced CD4+ T cells. J Immunol. 2010 Oct 15;185(8):4714-23. Epub 2010 Sep 20. PMID: 20855869 PMCID: PMC3014605

Wiemer AJ, Wernimont S, Huttenlocher A. Live imaging of LFA-1-dependent T-cell motility and stop  signals. Methods Mol Biol. 2012; 757:191-204. PMID: 21909914. PMCID: Policy Exempt - Not a peer-reviewed research article

Wernimont SA, Wiemer AJ, Monkley S, Critchley D, Ludwig TE, and Huttenlocher A. Contact-dependent T cell activation and T cell stopping require talin1.e. J Immunol. 2011 Dec 15;187(12):6256-67. Epub 2011 Nov 9. PMID:22075696 PMCID: PMC3237745.

Sackmann EK, Berthier E, Young EWK, Shelef MA, Wernimont SA, Huttenlocher A, Beebe DJ. Microfluidic kit-on-a-lid: a versatile platform for neutrophil chemotaxis assays. Blood. 2012 Oct 4;120(14):e45-53. doi: 10.1182/blood-2012-03-416453. Epub 2012 Aug 22. PMID: 22915642 PMCID: PMC3466974.

Rogers WK, Wernimont SA, Kumar GC, Bennet E, and Chestnut DH. 2012. Acute hypotension associated with intraoperative cell salvage using a leukocyte depletion filter during management of obstetric hemorrhage due to amniotic fluid embolism. Anesth Analg. 2013 Aug;117(2):449-52. doi: 10.1213/ANE.0b013e3182938079. Epub 2013 Jun 7. PMID: 23749444

Wiemer AJ, Wernimont SA, Cung TD, Bennin DA, Beggs HE, Huttenlocher A.The focal adhesion kinase inhibitor PF-562,271 impairs primary CD4+ T cell activation.Biochem Pharmacol. 2013 Sep 15;86(6):770-81. doi: 10.1016/j.bcp.2013.07.024. Epub 2013 Aug 5. PMID: 23928188 PMCID: PMC3762933

Mathis L, Wernimont S, Affentranger S, Huttenlocher A, Niggli V. Determinants of phosphatidylinositol-4-phosphate 5-kinase type Iγ90 uropod location in T-lymphocytes and its role in uropod formation.PeerJ. 2013 Aug 29;1:e131 PMID:24010013 PMCID:PMC3757496

Pope, Nathanial James
Mentor: Bresnick, Emery
Years in RTH T32 Program: 2009-2010

Recent Publications:

Katsumura KR, DeVilbiss AW, Pope NJ, Johnson KD, Bresnick EH.Transcriptional mechanisms underlying hemoglobin synthesis.Cold Spring Harb Perspect Med. 2013 Sep 1;3(9):a015412. doi: 10.1101/cshperspect.a015412. Review. PMID:23838521

Pope NJ, Bresnick EH. Establishment of a cell-type-specific genetic network by the mediator complex component Med1. Mol Cell Biol. 2013 May;33(10):1938-55. doi: 10.1128/MCB.00141-13. Epub 2013 Mar 4. PMID: 23459945PMCID: PMC3647965

McIver SC, Kang YA, DeVilbiss AW, O'Driscoll CA, Ouellette JN, Pope NJ, Camprecios G, Chang CJ, Yang D, Bouhassira EE, Ghaffari S, Bresnick EH. The exosome complex establishes a barricade to erythroid maturation. Blood. 2014 Aug 12. pii: blood-2014-04-571083. [Epub ahead of print]PMID:25115889 PMCID: PMC4183988

Pope NJ, Bresnick EH, Differential coregulator requirements for function of the hematopoietic transcription factor GATA-1 at endogenous loci. Nucleic Acids Res. 2010 Apr;38(7):2190-200. Epub 2010 Jan 4. PMID: 20048963PMCID: PMC2853107

Starnes, Taylor
Mentor: Huttenlocher, Anna
Years in RTH T32 Program: 2010-2011

Recent Publications:

Yang H, Pesavento JJ, Starnes TW, Cryderman DE, Wallrath LL, Kelleher NL, Mizzen CA. Preferential dimethylation of histone H4 lysine 20 by Suv4-20. J Biol Chem. 2008 May 2;283(18):12085-92. Epub 2008 Feb 21. PMID: 18296440 PMCID: PMC2335358

Starnes TW, Cortesio CL, Huttenlocher A. Imaging podosome dynamics and matrix degradation.Methods Mol Biol. 2011;769:111-36. doi: 10.1007/978-1-61779-207-6_9. PMID: 21748673 PMCID: PMC4209907

Yoo SK, Starnes TW, Deng Q, Huttenlocher A. Lyn is a redox sensor that mediates leukocyte wound attraction in vivo. Nature. 2011 Nov 20;480(7375):109-12. doi: 10.1038/nature10632 PMID: 22101434 PMCID: PMC3228893

Starnes TW, Huttenlocher A. Neutrophil Reverse Migration Becomes Transparent with Zebrafish. Adv Hematol. 2012;2012:398640. Epub 2012 Jul 12. PMID: 22844288 PMCID: PMC3401556

Starnes TW, Bennin DA, Bing X, Eickhoff JC, Grahf DC, Bellak JM, Seroogy CM, Ferguson PJ, Huttenlocher A. The F-BAR protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages.Blood. 2014 Apr 24;123(17):2703-14. doi: 10.1182/blood-2013-07-516948. Epub 2014 Jan 13.PMID:24421327 PMCID: PMC3999755

Tauzin S, Starnes TW, Becker FB, Lam PY, Huttenlocher A. Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration. J Cell Biol. 2014 Dec 8;207(5):589-98 PMID:25488917 PMCID:PMC4259815

Bischell, Lauren Lynn
Mentor: Beebe, David
Years in RTH T32 Program: 2012-2013

Bischel LL, Lee SH, Beebe DJ. A practical method for patterning lumens through ECM hydrogels via viscous finger patterning J Lab Autom. 2012 Apr;17(2):96-103. doi: 10.1177/2211068211426694. Epub 2012 Jan 24. PMID:22357560 PMCID: PMC3397721

Bischel LL, Young EW, Mader BR, Beebe DJ. Tubeless microfluidic angiogenesis assay with three-dimensional endothelial-lined microvessels. Biomaterials. 2013 Feb;34(5):1471-7. doi: 10.1016/j.biomaterials.2012.11.005. Epub 2012 Nov 26. PMID:23191982 PMCID: PMC3529167

Bischel LL, Mader BR, Green JM, Huttenlocher A, Beebe DJ. Zebrafish Entrapment By Restriction Array (ZEBRA) device: a low-cost, agarose-free zebrafish mounting technique for automated imaging. Lab Chip. 2013 May 7;13(9):1732-6. doi: 10.1039/c3lc50099c. PMID:23503983 PMCID: PMC4446983

Casavant BP, Berthier E, Theberge AB, Berthier J, Montanez-Sauri SI, Bischel LL, Brakke K, Hedman CJ, Bushman W, Keller NP, Beebe DJ. Suspended microfluidics.Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10111-6. doi: 10.1073/pnas.1302566110. Epub 2013 May 31. PMID:23729815 PMCID: PMC3690848

Bischel LL, Casavant BP, Young PA, Eliceiri KW, Basu HS, Beebe DJ. A microfluidic coculture and multiphoton FAD analysis assay provides insight into the influence of the bone microenvironment on prostate cancer cells. Integr Biol (Camb). 2014 May 27;6(6):627-35. doi: 10.1039/c3ib40240a.PMID: 24791272 PMCID: PMC4077588

Bischel LL, Sung KE, Jiménez-Torres JA, Mader B, Keely PJ, Beebe DJ. The importance of being a lumen. FASEB J. 2014 Jul 30. pii: fj.13-243733. [Epub ahead of print] PMID:25077562 PMCID: PMC4200326

Bischel LL, Beebe DJ, Sung KE. Microfluidic model of ductal carcinoma in situ with 3D, organotypic structure.BMC Cancer. 2015 Jan 21;15(1):12. [Epub ahead of print], PMID:25605670 PMCID: PMC4305264

Zanotelli MR, Ardalani H, Zhang J, Hou Z, Nguyen EH, Swanson S, Nguten BK, Bolin J, Elwell A, Bischel LL, Xie AW, Stewart R, Beebe DJ, Thomson JA, Schwartz, P, Murphy WL. Stable engineered vascular networks from human induced pluripotent stem cell-derived endothelial cells cultured in synthetic hydrogels. Acta Biomater 2016 Apr 15;35:32-41. doi 10.1155/j.actbio.2016.03.001 Epub2016 Mar 2. PMID: 26945632 PMCID: PMC4829480

Hope, Chelsea
Mentor: Asimokopoulos, Fotis
Years in RTH T32 Program: 2013-2015

Hebron E, Hope C, Kim J, Jensen JL, Flanagan C, Bhatia N, Maroulakou I, Mitsiades C, Miyamoto S, Callander N, Hematti P, Asimakopoulos F. MAP3K8 kinase regulates myeloma growth by cell-autonomous and non-autonomous mechanisms involving myeloma-associated monocytes/macrophages. Br J Haematol. 2013 Mar;160(6):779-84. doi: 10.1111/bjh.12175. Epub 2012 Dec 18.PMID:23252623 PMCID: PMC3594344

Asimakopoulos F, Kim J, Denu RA, Hope C, Jensen JL, Ollar SJ, Hebron E, Flanagan C, Callander N, Hematti P. Macrophages in multiple myeloma: emerging concepts and therapeutic implications. Leuk Lymphoma. 2013 Oct;54(10):2112-21. doi: 10.3109/10428194.2013.778409. Epub 2013 Apr 11. Review.PMID:23432691 PMCID: PMC3686978

Hope C, Ollar SJ, Heninger E, Hebron E, Jensen JL, Kim J, Maroulakou I, Miyamoto S, Leith C, Yang DT, Callander N, Hematti P, Chesi M, Bergsagel PL, Asimakopoulos F. TPL2 kinase regulates the inflammatory milieu of the myeloma niche. Blood. 2014 May 22;123(21):3305-15. doi: 10.1182/blood-2014-02-554071. Epub 2014 Apr 10. PMID:24723682 PMCID: PMC4046426

Jensen JL, Rakhmilevich A, Heninger E, Broman AT, Hope C, Phan F, Miyamoto S, Maroulakou I, Callander N, Hematti P, Chesi M, Bergsagel PL, Sondel P, Asimakopoulos F. Tumoricidal Effects of Macrophage-Activating Immunotherapy in a Murine Model of Relapsed/Refractory Multiple Myeloma. Cancer Immunol Res. 2015 Aug;3(8):881-90. doi: 10.11582326-6066.CIR-15-0025-T. Epub 2015 May 4. PMID: 25941352 PMCID: PMC4527950

Jensen JL, Hope C, Asimakopoulos F. Deploying myeloid cells against Myeloma. Oncoimmunology. 2015 Dec 10;5(3):e1090076. doi: 10.1080/21624002X.2015.1090076 eCollection 2016 Mar PMID: 27141348 PMCID: PMC4839315

Hope C, Foulcer S, Jagodinsky J, Chen SX, Jensen JL, Patel S, Leith C, Maroulakou I, Callander N, Miyamoto S, Hematti P, Apte SS. Immunoregulatory roles of versican protolysis in the myelma microenviroment. Blood, 2016 Aug 4; 128(5): 680-5. doi: 10.1182/blood-2016-.3-705780. Epub 2016 Jun 3, PMID 27259980 PMCID: PMC4974200

Asimakopoulos F, Hope C, Johnson MG, Pagenkopf A, Gromek K, Nagel B. Extracellular matrix and the myeloid-in-myeloma compartment: balancing tolerogenic and immunogenic inflammation in the myeloma niche. J Leukoc Biol. 2017 Aug; 102(2):265-275. doi:10.1189/jib.3MR1116-468R. Epub 2017 Mar. Review. PMID: 28254840. PMCID: PMC5505742

Hope C, Emmerich PB, Papadas A, Pagenkopf A, Matkowskyj KA, Van De Hay, DR, Payne SN,Clipson L, Callander NS, Hematti P, Miyamoto S, Johnson MG, Deming DA, Asimakopoulos F. Versican derivedmatrikines regulate Batf3-dendritic cell differnetiationand promoteT cell infiltration in colorectal cancer. J immunol. 2017 Sep 1:199(5): 1933-1941. doi: 10.4049/jimmunol. 1700529. Epub 2017 Jul 28.  PMID:28754680 PMCID: PMC5568487

Huynh M, Pak C, Markovina S, Callander NS, Chng KS, Wuerzberger-Davis SM, Bakshi DD, Kink JA, Hematti P, Hope C, Asimakopoulos F, Rui L, Miyamoto S. Hyaluronan andprotoeoglycan link protein 1 (HAPLN1) activates bortezomib-resistantNF-kB activity and increases drug resistance in multiple myeloma. J Biol Chem. 2018 Feb 16;293(7):2452-2465. doi: 10.1074/jbc.RA117.000667.Epub 2017 Dec26 PMID: 29279332 PMCID: PMC5818187

Dhakal B, Paggenkopf A, Umair Mushtaq M, Cunningham AM, Fleitner E, Morrow Z, Papadas A, Hope C, Leith C, Hematti P, Hari P, Callander NS, Asimakopoulos F. Versican protoelysis predictsimmune effector infiltration and post-transplant survival in Myeloma. Leuk Lymphoma 2019 Mar 8: 1-5. doi: 10.1080/10428194.2019.1585836. PMID 30845856

Wilkerson, Emily
Mentor: Coon, Joshua
Years in RTH T32 Program: 2014-2016

Wilkerson EM, Johansson MW, Hebert AS, Westphall MS, Mathur SK, Jarjour NN, Schwantes EA, Mosher DF, Coon JJ. The Peripheral Blood Eosinophil Proteome. J Proteome Res. 2016 May 6;15(5):1524-33. doi: 10.1021/acs.jproteome.6b00006. Epub 2016 Apr 1 PMID: 27005946

Baughman JM, Rose CM, Kolumam G, Webster JD, Wilkerson EM, Merrill AE, Rhoads TW, Noubade R, Katavolos P, Lesch J, Stapleton DS, Rabaglia ME, Schueler KL, Asuncion R, Domeyer M, Zavala-Solorio J, Reich M, DeVoss J, Keller MP, Attie AD, Hebert AS, Westphall MS, Coon JJ, Kirkpatrick DS, Dey A NeuCode Proteomics Reveals Bap1 Regulation of Metabolism. Cell Rep. 2016 Jul 12;16(2):583-95. doi: 10.1016/j.celrep.2016.05.096. Epub 2016 Jun 30. PMID: 27373151

Tefely JA, Licitra F, Laredj L, Reidenbach AG, Kemmerer ZA, Grangeray A, Jaeg-Ehret T, Minogue CE, Ulbrich A, Hutchins PD, Wilkerson EM, Ruan Z, Aydin D, Hebert AS, Guo X, Freiberger EC, Reutenauer L, Jochem A, Chergova M, Johnson IE, Lohman DC, Rush MJ, Kwiecien NW, Singh PK, Schlagowski AI, Floyd BJ, Forsman U, Sindelar PJ, Westphall MS, Pierrel F, Zoll J, Dal Peraro M, Kannan N, Bingman CA, Coon JJ, Isope P, Puccio H, Pagliarini DJ. Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity. Mol Cell. 2016 Aug 18;63(4):608-20. doi: 10.1016/j.molcel.2016.06.030. Epub 2016 Aug 4. PMID: 27499294 PMCID: PMC5012427

Floyd BJ, Wilkerson EM, Veling MT, Minogue CE, Xia C, Beebe ET, Wrobel RL, Cho H, Kremer LS, Alston CL, Gromek KA, Dolan BK, Ulbrich A, Stefely JA, Bohl SL, Werner KM, Jochem A, Westphall MS, Rensvold JW, Taylor RW, Prokisch H, Kim JJ, Coon JJ, Pagliarini DJ. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. Mol Cell. 2016 Aug 18;63(4):621-32. doi: 10.1016/j.molcel.2016.06.033. Epub 2016 Aug 4. PMID: 27499296 PMCID: PMC4992456

Mosher DF, Wilkerson EM, Turton KB, Hebert AS. Coon JJ. (2017) Proteomics of Eosinophil Activation. Front Med (Lausanne). 2017 Sep 29:4:159. doi: 10.3389/fmed.2017.00159. ecollection 2017 Review PMID 29034237 PMCID: PMC5626809

Reidenbach AG, Kemmerer ZA, Aydin D, Jochem A, McDevitt MT, Hutchins PD, Stark JL, Stefely JA, Reddy T, Hebert AS, Wilkerson EM, Johnson IE, Bingman CA, Markley JL, Coon JJ, Dal Peraro M, Pagliarini DJ. (2018), Conserved Lipid and Small-Molecule Modulation of COQ8 Reveals Regulation of the Ancient Kinase-like UbiB Family. Cell Chem Biol. 2018 Feb 15;25(2):154-165.e11. doi: 10.1016/j.chembiol.2017.11.001. Epub 2017 Nov 30. PMID: 29198567  PMCID: PMC5819996

Turton KB, Wilkerson EM, Hebert AS, Fogarty FJ, Schira HM, Botros FE, Coon JJ, Moshehr DF. Expression of novel"LOCGEF" isoforms of ARHGEF18 in eosinophils. J leukoc Biol. 2018 Jul; 104(1): 135-145. doi: 10.1002/JLB.2MA1017-418RR. Epub 2018 Mar30. PMID 29601110 PMCID: PMC6013370

Lohman DC, Aydin D, Von Bank HC, Smith RW, Linke V. Weisenhorn E, McDevitt MT, Hutchins P, Wilkerson EM, Wancewicz B, Russell J, Stefely MS, Beebe ET, Jochem A, Coon JJ, Bingham CA, Dal Peraro M, Paglirini DJ. An isoprene lipibinding protein promotes Eukaryotic Coenzme Q biosynthesis. Mol Cell. 2019 Feb 21;73(4):763-774.e10. doi: 10.1016/jmolcel.2018.11.033. Epub 2019Jan 17. PMID 30661980  PMCID: PMC6386619.

Zhu Y, Howard GA, Pittman K, Boykin C, Herring LE, Wilkerson EM, Verbanac K, Lu Q. Therapeutic Effect of Y-27632 on Tumorigenesis and Cisplatin-Induced Peripheral Sensory Loss through RhoA-NF-κB. Mol Cancer Res. 2019 Sep;17(9):1910-1919. doi: 10.1158/1541-7786.MCR-19-0024. Epub 2019 Jun 12.PMID: 31189689 PMCID: PMC6774348

 Hu L, Xie H, Liu X, Potjewyd F, James LI, Wilkerson EM, Herring LE, Xie L, Chen X, Cabrera JC, Hong K, Liao C, Tan X, Baldwin AS, Gong K, Zhang Q. TBK1 Is a Synthetic Lethal Target in Cancer with VHL Loss. Cancer Discov. 2020 Mar;10(3):460-475. doi: 10.1158/2159-8290.CD-19-0837. Epub 2019 Dec 6.PMID: 31810986 PMCID: PMC7058506

McDonald IM, Grant GD, East MP, Gilbert TSK, Wilkerson EM, Goldfarb D, Beri J, Herring LE, Vaziri C, Cook JG, Emanuele MJ, Graves LM Mass spectrometry-based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells J Biol Chem. 2020 Feb 21;295(8):2359-2374. doi: 10.1074/jbc.RA119.011083. Epub 2020 Jan 2.PMID: 31896573 PMCID:PMC7039562

Jong CJ, Merrill RA, Wilkerson EM, Herring LE, Graves LM, Strack S. Reduction of protein phosphatase 2A (PP2A) complexity reveals cellular functions and dephosphorylation motifs of the PP2A/B'δ holoenzyme J Biol Chem. 2020 Apr 24;295(17):5654-5668. doi: 10.1074/jbc.RA119.011270. Epub 2020 Mar 10.PMID: 32156701 PMCID: PMC7186168 

José A. Jiménez-Torres
Mentor: Beebe, David
Years in RTH T32 Program: 2015-2016

Bischel LL, Sung KE, Jiménez-Torres JA, Mader B, Keely PJ, Beebe DJ. The importance of being a lumen. FASEB J. 2014 Nov;28(11):4583-90. doi: 10.1096/fj.13-243733. Epub 2014 Jul 30. PMID: 25077562 PMCID: PMC4200326

Gavira JA, Cera-Manjarres A, Ortiz K, Mendez J, Jimenez-Torres JA, Patiño-Lopez LD, Torres-Lugo M. Use of Cross-Linked Poly(ethylene glycol)-Based Hydrogels for Protein Crystallization Cryst Growth Des. 2014 Jul 2;14(7):3239-3248. Epub 2014 May 14. PMID: 25383049 PMCID: PMC4215911

Jiménez-Torres JA, Peery SL, Sung KE, Beebe DJ. Adv Healthc Mater.LumeNEXT: A Practical Method to Pattern Luminal Structures in ECM Gels 2016 Jan 21;5(2):198-204. doi: 10.1002/adhm.201500608. Epub 2015 Nov 26.PMID: 26610188 PMCID: PMC4776323

Jiménez-Torres JA, Beebe DJ, Sung KE. A Microfluidic Method to Mimic Luminal Structures in the Tumor Microenvironment. Methods Mol Biol. 2016;1458:59-69. doi: 10.1007/978-1-4939-3801-8_5. PMID: 27581014

Lam J, Marklein RA, Jimenez-Torres JA, Beebe DJ, Bauer SR, Sung KE. (2017). Adaptation of a Simple Microfluidic Platform for High-Dimensional Quantitative Morphological Analysis of Human Mesenchymal Stromal Cells on Polystyrene-Based Substrates. SLAS Technol. 2017 Dec;22(6):646-661. doi: 10.1177/2472630317726050. Epub 2017 Aug 21. PMID:28825968 PMCID: PMC7222604

Barkal LJ, Procknow CL, Álvarez-García YR, Niu M, Jiménez-Torres JA, Brockman-Schneider RA, Gern JE, Denlinger LC, Theberge AB, Keller NP, Berthier E, Beebe DJ. Microbial volatile communication in human organotypic lung models. Nat Commun. 2017 Nov 24;8(1):1770. doi: 10.1038/s41467-017-01985-4. PMID 29176665  PMCID: PMC5701243

Jiménez-Torres JA, Virumbrales-Muñoz M, Sung KE, Lee MH, Abel EJ, Beebe DJ. Patient-specific organotypic blood vessels as an in vitro model for anti-angiogenic drug response testing in renal cell carcinoma EBioMedicine. 2019 Apr;42:408-419. doi: 10.1016/j.ebiom.2019.03.026. Epub 2019 Mar 20.PMID: 30902740 PMCID: PMC6491391

Anu Prathap MU, Castro-Pérez E, Jiménez-Torres JA, Setaluri V, Gunasekaran S.  A flow-through microfluidic system for the detection of circulating melanoma cellsBiosens Bioelectron. 2019 Oct 1;142:111522. doi: 10.1016/j.bios.2019.111522. Epub 2019 Jul 17.PMID: 31336226PMCID: PMC6718307

Meargert, Aisha
Mentor: Shelef, Miriam
Years in RTH T32 Programs: 2020 - 2021

Mergaert AM, Bawadekar M, Nguyen TQ, Massarenti L, Holmes CL, Rebernick R, Schrodi SJ, Shelef MA. Reduced Anti-Histone Antibodies and Increased Risk of Rheumatoid Arthritis Associated with a Single Nucleotide Polymorphism in PADI4 in North Americans,Int J Mol Sci. 2019 Jun 25;20(12):3093. doi: 10.3390/ijms20123093.PMID: 31242568 PMCID:PMC6627847

Zheng Z, Mergaert AM, Fahmy LM, Bawadekar M, Holmes CL, Ong IM, Bridges AJ, Newton MA, Shelef MA. Disordered Antigens and Epitope Overlap Between Anti-Citrullinated Protein Antibodies and Rheumatoid Factor in Rheumatoid Arthritis.Arthritis Rheumatol. 2020 Feb;72(2):262-272.doi: 10.1002/art.41074. Epub 2019 Dec 10. PMID: 31397047 PMCID: PMC6994383

Amjadi MF, O'Connell SE, Armbrust T, Mergaert AM, Narpala SR, Halfmann PJ, Bashar SJ, Glover CR, Heffron AS, Taylor A, Flach B, O'Connor DH, Kawaoka Y, McDermott AB, Sethi AK, Shelef MA. Fever, Diarrhea, and Severe Disease Correlate with High Persistent Antibody Levels against SARS-CoV-2.medRxiv. 2021 Jan 6:2021.01.05.21249240. doi: 10.1101/2021.01.05.21249240. Preprint.PMID: 33442707 PMCID: PMC7805469

Zheng Z, Mergaert AM, Ong IM, Shelef MA, Newton MA. MixTwice: large-scale hypothesis testing for peptide arrays by variance mixingBioinformatics. 2021 Mar 8;37(17):2637-43. doi: 10.1093/bioinformatics/btab162. Online ahead of print.PMID: 33693483 PMCID: PMC8428605

Amjadi MF, O'Connell SE, Armbrust T, Mergaert AM, Narpala SR, Halfmann PJ, Bashar SJ, Glover CR, Heffron AS, Taylor A, Flach B, O'Connor DH, Kawaoka Y, McDermott AB, Sethi AK, Shelef MA. Specific COVID-19 Symptoms Correlate with High Antibody Levels against SARS-CoV-2Immunohorizons. 2021 Jun 17;5(6):466-476. doi: 10.4049/immunohorizons.2100022.PMID: 34398806 PMCID: PMC8462279

Holmes, Caitlin
Mentor: Shelef, Miriam
Years in RTH T32 Programs:2017 - 2020

Rebernick R, Fahmy L, Glover C, Bawadekar M, Shim D, Holmes CL, Rademacher N, Potluri H, Bartels CM, Shelef MA. DNA Area and NETosis Analysis (DANA): a High-Throughput Method to Quantify Neutrophil Extracellular Traps in Fluorescent Microscope Images. Biol Proced Online. 2018 Apr 1;20:7. doi: 10.1186/s12575-018-0072-y. eCollection 2018.PMID: 29618953 PMCID: PMC5878938

Holmes CL, Shim D, Kernien J, Johnson CJ, Nett JE,Shelef MA. Insight into neutrophil extracelleular traps through systematic evaluation of citrullination and peptidylarginine Deiminases. J Immunol Res. 2019 Mar 12;2019:2160192. doi: 10.1155/2019/2160192. eCollection 2019. PMID: 30993117 PMCID: PMC6434303

Holmes CL, Peyton CG, Kerien J, Johnson CJ, Nett JE, Shelef MA. Reduced lgG titers against pertusis in rheumatoid arthritis: Evidence for a citruline-biased immune response and medication effects. PLoS One.  2019 May 28:14(5):e0217221. doi: 10.1371/journal.pone. 027221. eCollection 2019 PMID" 31136605 PMCID: PMC6538243

Mergaert AM, Bawadekar M, Nguyen TQ, Massarenti L, Holmes CL, Rebernick R, Schrodi SJ, Shelef MA. Reduced Anti-Histone Antibodies and Increased Risk of Rheumatoid Arthritis Associated with a Single Nucleotide Polymorphism in PADI4 in North Americans,Int J Mol Sci. 2019 Jun 25;20(12):3093. doi: 10.3390/ijms20123093.PMID: 31242568 PMCID:PMC6627847

Zheng Z, Mergaert AM, Fahmy LM, Bawadekar M, Holmes CL, Ong IM, Bridges AJ, Newton MA, Shelef MA. Disordered Antigens and Epitope Overlap Between Anti-Citrullinated Protein Antibodies and Rheumatoid Factor in Rheumatoid Arthritis.Arthritis Rheumatol. 2020 Feb;72(2):262-272.doi: 10.1002/art.41074. Epub 2019 Dec 10. PMID: 31397047 PMCID: PMC6994383

Sun B, Chang HH, Salinger A, Tomita B, Bawadekar M, Holmes CLShelef MA, Weerapana E, Thompson PR, Ho Reciprocal regulation of Th2 and Th17 cells by PAD2-mediated citrullination.IC.JCI Insight. 2019 Nov 14;4(22):e129687. doi: 10.1172/jci.insight.129687.PMID: 31723060 PMCID: PMC6948856

Walker, Kirsti
Mentor: Capitini, Christian
Years in RTH T32 Programs:2017 - 2019

Lieberman NAP, DeGolier K, Haberthur K, Chinn H, Moyes KW, Bouchlaka MN, Walker KLCapitini CM, Crane CA. An Uncoupling of Canonical Phenotypic Markers and Functional Potency of Ex Vivo-Expanded Natural Killer Cells. Front Immunol. 2018 Feb 2;9:150. doi: 10.3389/fimmu.2018.00150. eCollection 2018.PMID: 29456538

Hernandez R, Walker KL, Grudzinski JJ, Aluicio-Sarduy E, Patel R, Zahm CD, Pinchuk An, Massey CF,Bitton AN, Brown RJ, Sondel PM, Morris ZS, Engle JW, Capitini CM, Weichert JP.  90Y-NM600 targeted induces immunologic memory in synergeneic models of T-cell Non-Hodgkins Lymphoma. Commun Biol. 2019 Feb 26;2:79. doi: 10.1038/s42003-019-0327-4. eCollection 2019

Damodharan SN, Walker KL, Forsberg MH, McDowell KA, Bouchlaka MN, Drier DA, Sondel PM, DeSantes KB, Capitini CM. Analysis of ex vivo expanded and activated clinical-grade human NK cells after cryopreservation. Cytotherapy. 2020 Aug;22(8):450-457. doi: 10.1016/j.jcyt.2020.05.001. Epub 2020 Jun 11.PMID: 32536506  PMCID: PMC7387178

Walker KL, Rinella SP, Hess NJ, Turicek DP, Kabakov SA, Zhu F, Bouchlaka MN, Olson SL, Cho MM, Quamine AE, Feils AS, Gavcovich TB, Rui L, Capitini CM. CXCR4 allows T cell acute lymphoblastic leukemia to escape from JAK1/2 and BCL2 inhibition through CNS infiltration. Leuk Lymphoma. 2021 May;62(5):1167-1177. doi: 10.1080/10428194.2021.1910684. Epub 2021 Apr 11.PMID: 33843403 PMCID: PMC8432301

Lechuga LM, Forsberg MH, Walker KL, Ludwig KD, Capitini CM, Fain SB.Detection and viability of murine NK cells in vivo in a lymphoma model using fluorine-19 MRI.NMR Biomed. 2021 Aug 18:e4600. doi: 10.1002/nbm.4600. Online ahead of print.PMID: 34409665

Past Post-doctoral Trainees:

Popescu, Marcela
Mentor: Dovat, Sinisa
Years in RTH T32 Program: 2005-2007

Recent Publications:

Popescu M, Gurel Z, Ronni T, Song C, Hung KY, Payne KJ, Dovat, S. Ikaros stability and pericentromeric localization are regulated by protein phosphatase 1. J Biol Chem 2009 May 15;284(20):13869-80. Epub 2009 Mar 11 PMCID: PMC2679487

Blevins A, Popescu M, Klopfenstein K. Embroynal Rhabdomyosarcoma: An Unusual Presentation. Abstract 186. Presented at the Southern Regional Meeting, Feb 2011.

Gupta D, Popescu M, Strickland K. Hodgkin’s Disease: It is in the Neck, Alright! Presented at the Southern Society of Pediatric Research, Feb 2012

Nett, Jeniel E.
Mentor: Andes, David
Years in RTH T32 Program: 2005-2008

Recent Publications:

Lepak A, Nett J, Lincoln L, Marchillo K, Andes D. Time course of microbiologic outcome and gene expression in Candida albicans during and following in vitro and in vivo exposure to fluconazole. Antimicrob Agents Chemother. 2006;50(4):1311-1319. PMCID: PMC1426956

Andes D, Forrest A, Lepak A, Nett J, Marchillo K, Lincoln L. Impact of antimicrobial dosing regimen on evolution of drug resistance in vivo: fluconazole and Candida albicans. Antimicrob Agents Chemother. 2006;50(7):2374-2383. PMCID: PMC1489796

Andes D, Lepak A, Nett J, Lincoln L, Marchillo K. In vivo fluconazole pharmacodynamics and resistance development in a previously susceptible Candida albicans population examined by microbiologic and transcriptional profiling. Antimicrob Agents Chemother. 2006;50(7):2384-2394. PMCID: PMC1489797

Nett J, Andes D. Candida albicans biofilm development, modeling a host-pathogen interaction. Curr Opin Microbiol. 2006 Aug;9(4):340-5. Epub 2006 Jun 30. Review. PMID: 16815078

Nobile CJ, Andes D, Nett J, Smith F, Yue F, Phan Q, Endwards J, Filler S, Mitchell AP. Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo. PLoS Pathog. 2006;2(7):1-13. (Cover image and Editor's choice in Science 313:411) PMCID: PMC1487173

Nobile, CJ, Nett JE, Andes DR, Mitchell AP. Function of Candida albicans adhesin Hwp1 in biofilm formation. Eukaryot Cell. 2006 Oct;5(10):1604-1610. PMCID: PMC1595337

Nett J, Lincoln L., Marchillo K., Andes D. β-1,3 glucan as a test for central venous catheter biofilm infection. J Infect Dis. 2007 Jun 1;195(11):1705-12. Epub 2007 Apr 17. PMID: 17471441

Nett J, Lincoln L, Marchillo K, VanHandel M, D Andes. 2007. Putative role of β-1,3 glucans in Candida albicans biofilm resistance. Antimicrob Agents Chemother. 2007 Feb;51(2):510-20. Epub 2006 Nov 27. PMCID: PMC1797745

Nett JE, Guite KM, Ringeisen A, Holoyda KA, DR Andes. Reduced biocide susceptibility in Candida albicans biofilms. Antimicrob Agents Chemother. 52(9):3411-3413. Epub 2008 Jun 23. PMCID: PMC2533490

Uppuluri P, Nett J, Heitman J, Andes D. Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms. Antimicrob Agents Chemother. 2008 Mar;52(3):1127-32. Epub 2008 Jan 7. PMCID: PMC2258509

Nobile CJ, Schneider HA, Nett JE, Sheppard DC, Filler SG, Andes DR, Mitchell AP. Complementary adhesin function in C. albicans biofilm formation. Curr Biol. 2008 Jul. 18(14):1017-24. PMCID: PMC2504253

Nobile C, Nett J, Hernday A, Homann O, Deneault J, Nantel A, Andes D, Johnson A, Mitchell A. Biofilm matrix regulation by Candida albicans Zap1. PLoS Biol. 2009 Jun;7(6):e1000133. Epub 2009 Jun 16. Highlighted in Nature Reviews 7, 2009. PMCID: PMC2688839

Nett JE, Lepak AJ, Marchillo K, Andes DR. Time course global gene expression analysis of an in vivo Candida biofilm. J Infect Dis. 200(2):307-313. (Cover image) J Infect Dis. 2009 Jul 15;200(2):307-13. PMCID: PMC3159582

Nett JE, Marchillo K, Spiegel CA, Andes DR. Development and validation of an in vivo Candida albicans biofilm denture model. Infect Immun. 2010 Sep;78(9):3650-9. Epub 2010 Jul 6. PMCID: PMC2937450

Nett JE, Crawford K, Marchillo K, Andes DR. Role of Fks1p and matrix glucan on C. albicans biofilm resistance to an echinocandin, pyrimidine, and polyene. Antimicrob Agents Chemother. 2010 Aug;54(8):3505-8. Epub 2010 Jun 1. PMCID: PMC2916329

Nett JE, Sanchez H, Cain MT, Andes DR. Genetic basis of Candida biofilm resistance due to drug sequestering matrix glucan. Accepted J Infect Dis. J Infect Dis. 2010 Jul 1;202(1):171-5. PMCID: PMC2880631

Nett JE, Cain MT, Crawford K, Andes DR. Optimizing a Candida biofilm microtiter plate model for measurement of antifungal susceptibility by tetrazolium salt assay. J Clin Microbiol. 2011 Apr;49(4):1426-33. doi: 10.1128/JCM.02273-10. Epub 2011 Jan 12. PMID:21227984

Finkel JS, Yudanin N, Nett JE, Andes DR, Mitchell AP. Application of the systematic "DAmP" approach to create a partially defective C. albicans mutant. Fungal Genet Biol. 2011 Nov;48(11):1056-61. doi: 10.1016/j.fgb.2011.07.005. Epub 2011 Jul 27. PMID:21820070

Nett JE, Sanchez H, Cain MT, Ross KM, Andes DR. Interface of Candida albicans biofilm matrix-associated drug resistance and cell wall integrity regulation. Eukaryot Cell. 2011 Dec;10(12):1660-9. Epub 2011 Jun 10. PMCID: PMC3232725

Chen YL, Brand A, Morrison EL, Silao FG, Bigol UG, Malbas FF Jr, Nett JE, Andes DR, Solis NV, Filler SG, Averette A, Heitman J. Calcineurin controls drug tolerance, hyphal growth, and virulence in Candida dubliniensis. Eukaryot Cell. 2011 Jun;10(6):803-19. Epub 2011 Apr 29. PMCID: PMC3127677

Taff HT, Nett JE, Andes DR. Comparative analysis of Candida biofilm quantitation assays. Med Mycol. 2012 Feb;50(2):214-8. Epub 2011 May 4. PMCID: PMC3251704

Nobile CJ, Fox EP, Nett JE, Sorrells TR, Mitrovich QM, Hernday AD, Tuch BB, Andes DR, Johnson AD. A recently evolved transcriptional network controls biofilm development in Candida albicans. Cell. 2012 Jan 20;148(1-2):126-38. PMCID: PMC3266547

Nett JE, Marchillo K, Andes DR. Modeling of fungal biofilms using a rat central vein catheter. Methods Mol Biol. 2012;845:547-56. PMCID: PMC3341608

Taff HT, Nett JE, Zarnowski R, Ross KM, Sanchez H, Cain MT, Hamaker J, Mitchell AP, Andes DR. A Candida biofilm-induced pathway for matrix glucan delivery: implications for drug resistance. PLoS Pathog. 2012 Aug;8(8):e1002848. PMCID: PMC3410897

Finkel JS, Xu W, Huang D, Hill EM, Desai JV, Woolford CA, Nett JE, Taff H, Norice CT, Andes DR, Lanni F, Mitchell AP. Portrait of Candida albicans adherence regulators. PLoS Pathog. 2012 Feb;8(2):e1002525.. PMCID: PMC3280983

Nett JE, Brooks E, Cabezas-Olcoz J, Sanchez H, Zarnowski R, Marchillo K, Andes DR. Rat Indwelling Urinary Catheter Model of Candida albicans Biofilm Infection. Infect Immun. 2014 Sep 2. pii: IAI.02284-14. [Epub ahead of print] PMID:25183731

Zarnowski R, Westler WM, Lacmbouh GA, Marita JM, Bothe JR, Bernhardt J, Lounes-Hadj Sahraoui A, Fontaine J, Sanchez H, Hatfield RD, Ntambi JM, Nett JE, Mitchell AP, Andes DR. Novel entries in a fungal biofilm matrix encyclopedia. MBio. 2014 Aug 5;5(4):e01333-14. doi: 10.1128/mBio.01333-14. PMID:25183731

Nett JE.Future directions for anti-biofilm therapeutics targeting Candida.Expert Rev Anti Infect Ther. 2014 Mar;12(3):375-82. doi: 10.1586/14787210.2014.885838. Epub 2014 Feb 9.PMID:24506174

Wassenaar, Timothy
Mentor: Hematti, Peiman
Years in RTH T32 Program: 2006-2007

Recent Publications:

Wassenaar T, Feldstein D. Do prophylactic anticonvulsants in patients with brain tumors decrease the incidence of seizures? Wis Med J 2005; 104:6. Policy Exempt - accepted for publications prior to 4/7/08.

Wassenaar TR, Eickhoff JC, Jarzemsky DR, Smith SS, Larson ML, Schiller JH. Differences in primary care clinicians' approach to non-small cell lung cancer patients compared with breast cancer. J Thorac Oncol. 2007 Aug;2(8):722-8. PMID: 17762338 PMCID: Policy Exempt - accepted for publications prior to 4/7/08.

Wassenaar T, Black J, Kahl B, Schwartz B, Longo W, Mosher D, Williams E. Acute promyelocytic leukaemia and acquired alpha-2-plasmin inhibitor deficiency: a retrospective look at the use of epsilon-aminocaproic acid (Amicar) in 30 patients. Hematol Oncol. 2008 Dec;26(4):241-6. PMID:18613223 PMCID: Policy Exempt - Not resulting from NIH funding.

Dodd, Michael Ernest
Mentor: Huttenlocher, Anna
Years in RTH T32 Program: 2005-2007

Recent Publications:

Bollag WB, Zhong X, Dodd ME, Hardy DM, Zheng X and Allred WT. Phospholipase D Signaling and Extracellular Signal-Regulated Kinase (ERK)-1 and 2 Phosphorylation (Activation) are Required for Maximal Phorbol Ester-Induced Transglutaminase Activity, a Marker of Keratinocyte Differentiation. J Pharmacol Exp Ther. 312(3): 1223-1231, 2005. [Epub Nov 10, 2004]. PMID: 15537826

Dodd ME, Ristich VL, Ray S, Lober RM and Bollag WB. Regulation of Protein Kinase D during Differentiation and Proliferation of Primary Mouse Keratinocytes. J Invest Dermatol. 2005. 125(2):294-306. PMID: 16098040

Ristich VL, Bowman PH, Dodd ME, and Bollag WB. Protein Kinase D Distribution in Normal Human Epidermis, Basal Cell Carcinoma and Psoriasis. Br J Dermatol. 2006. 154(4): 586-93. PMID: 16536798

Mathias JR, Dodd ME, Walters KB, Yoo SK, Ranheim EA, Huttenlocher A. Characterization of zebrafish larval inflammatory macrophages. Dev Comp Immunol. 2009 Nov;33(11):1212-7. Epub 2009 Jul 29. PMCID: PMC2742687

Delgado, David
Mentor: Dovat, Sinisa
Years in RTH T32 Program: 2006-2008

Recent Publications:

Delgado DC, Hank JA, Kolesar J, et al. Genotypes of NK cell KIR receptors, their ligands, and Fcgamma Receptors in the response of neuroblastoma patients to Hu14.18-IL2 immunotherapy. Cancer Res. 2010 Dec 1; 70(23): 9554-61. PMCID: PMC2999644

Delgado D, Webster DE, DeSantes KB, Durkin ET, Shaaban AF. KIR receptor-ligand incompatibility predicts killing of osteosarcoma cell lines by allogeneic NK cells. Pediatr Blood Cancer. 2010 Dec 15; 55(7): 1300-05. PMCID: PMC3081247

Saber, Wael
Mentor: Williams, Eliot
Years in RTH T32 Program: 2006-2008

Recent Publications:

Saber W. Perioperative medication management: a case-based review of general principles. Cleve Clin J Med. 2006 Mar;73 Suppl 1:S82-7. PMID: 16570555

Brotman D, Bakhru M, Saber W, Aneja A, Bhatt D, Tillan-Martinez K, and Jaffer A. Discontinuation of Anti-platelet therapy prior to low risk non-cardiac surgery in patients with drug-eluting stents: a retrospective cohort study. J Hosp Med. 2007 Nov;2(6):378-84. PMID: 18081175. PMCID: Policy Exempt - accepted for publication prior to 4/7/08.

Advani AS, Jin T, Ramsingh G, Tiu R, Saber W, Theil K, Sobecks R, Sekeres M, Copelan E, Sungren S, Tripp B, Kalaycio M. Time to post-remission therapy is an independent prognostic factor in adults with acute lymphoblastic leukemia. Leuk Lymphoma. 2008 Aug; 49 (8):1560-6. PMID: 18766970. PMCID: Policy Exempt - not resulting from NIH funding.

Saber W, Williams EC. Cytogenetically Normal Acute Myeloid Leukemia. N Engl J Med. 2008 Aug 7; 359 (6):652; author reply 652-3. PMID: 18697247. PMCID: Policy Exempt-not from NIH funding.

Advani AS, Rodriguez C, Jin T, Jawde RA, Saber W, Baz R, Kalaycio M, Sobecks R, Sekeres M, Tripp B, Hsi E. Increased C-kit intensity is a poor prognostic factor for progression-free and overall survival in patients with newly diagnosed AML. Leuk Res. 2008 Jun;32(6):913-8. PMID: 17928050. PMCID: Policy Exempt - accepted for publication prior to 4/7/08.

Drobyski WR, Pasquini M, Kovatovic K, Palmer J, Douglas Rizzo J, Saad A, Saber W, Hari P. Tocilizumab for the treatment of steroid refractory graft-versus-host disease. Biol Blood Marrow Transplant. 2011 Dec;17(12):1862-8. Epub 2011 Jul 13. PMID: 21745454. PMCID: Policy Exempt - not resulting from NIH funding.

Battiwalla M, Ellis K, Li P, Pavletic SZ, Akpek G, Hematti P, Klumpp TR, Maziarz RT, Savani BN, Aljurf MD, Cairo MS, Drobyski WR, George B, Hahn T, Khera N, Litzow MR, Loren AW, Saber W, Arora M, Urbano-Ispizua A, Cutler C, Flowers ME, Spellman SR. HLA DR15 Antigen Status Does Not Impact Graft-versus-Host Disease or Survival in HLA-Matched Sibling Transplantation for Hematologic Malignancies. Biol Blood Marrow Transplant. 2012 Aug;18(8):1302-8. Epub 2012 Mar 10. PMID: 22414493. NIHMSID: NIHMS363489

Ballen KK, Woolfrey AE, Zhu X, Ahn KW, Wirk B, Arora M, George B, Savani BN, Bolwell B, Porter DL, Copelan E, Hale G, Schouten HC, Lewis I, Cahn JY, Halter J, Cortes J, Kalaycio ME, Antin J, Aljurf MD, Carabasi MH, Hamadani M, McCarthy P, Pavletic S, Gupta V, Deeg HJ, Maziarz RT, Horowitz MM, Saber W. Allogeneic Hematopoietic Cell Transplantation for Advanced Polycythemia Vera and Essential Thrombocythemia. Biol Blood Marrow Transplant. 2012 Mar 24. [Epub ahead of print] PMID: 22449610. NIHMSID: NIHMS403686..

Saber W, Opie S, Rizzo JD, Zhang MJ, Horowitz MM, Schriber J. Outcomes after matched unrelated donor versus identical sibling hematopoietic cell transplantation in adults with acute myelogenous leukemia. Blood. 2012 Apr 26;119(17):3908-16. Epub 2012 Feb 10. PMCID: PMC3350357

Cook RJ, Wang Z, Arora M, Lazarus HM, Kasow KA, Champagne MA, Saber W, van Besien KM, Hale GA, Copelan EA, Elmongy M, Ueno NT, Horn BN, Slavin S, Bishop MR, Stadtmauer EA. Clinical outcomes of patients with desmoplastic small round cell tumor of the peritoneum undergoing autologous HCT: a CIBMTR retrospective analysis. Bone Marrow Transplant. 2012 Nov;47(11):1455-8. doi: 10.1038/bmt.2012.57. Epub 2012 Apr 2.PMID:22465977

Michaelis LC, Saad A, Zhong X, Le-Rademacher J, Freytes CO, Marks DI, Lazarus HM, Bird JM, Holmberg L, Kamble RT, Kumar S, Lill M, Meehan KR, Saber W, Schriber J, Tay J, Vogl DT, Wirk B, Savani BN, Gale RP, Vesole DH, Schiller GJ, Abidi M, Anderson KC, Nishihori T, Kalaycio ME, Vose JM, Moreb JS, Drobyski W, Munker R, Roy V, Ghobadi A, Holland HK, Nath R, To LB, Maiolino A, Kassim AA, Giralt SA, Landau H, Schouten HC, Maziarz RT, Mikhael J, Kindwall-Keller T, Stiff PJ, Gibson J, Lonial S, Krishnan A, Dispenzieri A, Hari P; Plasma Cell Disorders Working Committee of the Center for International Blood and Marrow Transplant Research. Salvage second hematopoietic cell transplantation in myeloma. Biol Blood Marrow Transplant. 2013 May;19(5):760-6. doi: 10.1016/j.bbmt.2013.01.004. Epub 2013 Jan 5.PMID:23298856

Ayas M, Saber W, Davies SM, Harris RE, Hale GA, Socie G, LeRademacher J, Thakar M, Deeg HJ, Al-Seraihy A, Battiwalla M, Camitta BM, Olsson R, Bajwa RS, Bonfim CM, Pasquini R, Macmillan ML, George B, Copelan EA, Wirk B, Al Jefri A, Fasth AL, Guinan EC, Horn BN, Lewis VA, Slavin S, Stepensky P, Bierings M, Gale RP. Allogeneic hematopoietic cell transplantation for fanconi anemia in patients with pretransplantation cytogenetic abnormalities, myelodysplastic syndrome, or acute leukemia. J Clin Oncol. 2013 May 1;31(13):1669-76. doi: 10.1200/JCO.2012.45.9719. Epub 2013 Apr 1.PMID:23547077

Hurley CK, Woolfrey A, Wang T, Haagenson M, Umejiego J, Aljurf M, Askar M, Battiwalla M, Dehn J, Horan J, Oudshoorn M, Pidala J, Saber W, Turner V, Lee SJ, Spellman SR. The impact of HLA unidirectional mismatches on the outcome of myeloablative hematopoietic stem cell transplantation with unrelated donors. Blood. 2013 Jun 6;121(23):4800-6. doi: 10.1182/blood-2013-01-480343. Epub 2013 May 1.PMID:23637130

Hamadani M, Saber W, Ahn KW, Carreras J, Cairo MS, Fenske TS, Gale RP, Gibson J, Hale GA, Hari PN, Hsu JW, Inwards DJ, Kamble RT, Klein A, Maharaj D, Marks DI, Rizzieri DA, Savani BN, Schouten HC, Waller EK, Wirk B, Lazarus HM  Allogeneic hematopoietic cell transplantation for chemotherapy-unresponsive mantle cell lymphoma: a cohort analysis from the center for international blood and marrow transplant research. Biol Blood Marrow Transplant. 2013 Apr;19(4):625-31. doi: 10.1016/j.bbmt.2013.01.009. Epub 2013 Jan 17.PMID:23333532

Hamadani M, Saber W, Ahn KW, Carreras J, Cairo MS, Fenske TS, Gale RP, Gibson J, Hale GA, Hari PN, Hsu JW, Inwards DJ, Kamble RT, Klein A, Maharaj D, Marks DI, Rizzieri DA, Savani BN, Schouten HC, Waller EK, Wirk B, Laport GG, Montoto S, Maloney DG, Lazarus HM. Impact of pretransplantation conditioning regimens on outcomes of allogeneic transplantation for chemotherapy-unresponsive diffuse large B cell lymphoma and grade III follicular lymphoma. Biol Blood Marrow Transplant. 2013 May;19(5):746-53. doi: 10.1016/j.bbmt.2013.01.024. Epub 2013 Feb 1.PMID:23380340

Hurley CK, Woolfrey A, Wang T, Haagenson M, Umejiego J, Aljurf M, Askar M, Battiwalla M, Dehn J, Horan J, Oudshoorn M, Pidala J, Saber W, Turner V, Lee SJ, Spellman SR. The impact of HLA unidirectional mismatches on the outcome of myeloablative hematopoietic stem cell transplantation with unrelated donors. Blood. 2013 Jun 6;121(23):4800-6. doi: 10.1182/blood-2013-01-480343. Epub 2013 May 1.PMID:23637130

Cornell RF, Hari P, Zhang MJ, Zhong X, Thompson J, Fenske TS, Horowitz MM, Komorowski R, Palmer J, Pasquini MC, Rizzo JD, Saber W, Thomas M, Drobyski WR.Divergent effects of novel immunomodulatory agents and cyclophosphamide on the risk of engraftment syndrome after autologous peripheral blood stem cell transplantation for multiple myeloma. Biol Blood Marrow Transplant. 2013 Sep;19(9):1368-73. doi: 10.1016/j.bbmt.2013.06.017. Epub 2013 Jun 24.PMID:23806770

Maziarz RT, Wang Z, Zhang MJ, Bolwell BJ, Chen AI, Fenske TS, Freytes CO, Gale RP, Gibson J, Hayes-Lattin BM, Holmberg L, Inwards DJ, Isola LM, Khoury HJ, Lewis VA, Maharaj D, Munker R, Phillips GL, Rizzieri DA, Rowlings PA, Saber W, Satwani P, Waller EK, Maloney DG, Montoto S, Laport GG, Vose JM, Lazarus HM, Hari PN. Autologous haematopoietic cell transplantation for non-Hodgkin lymphoma with secondary CNS involvement. Br J Haematol. 2013 Sep;162(5):648-56. doi: 10.1111/bjh.12451. Epub 2013 Jul 6.PMID:23829536

Saber W, Cutler CS, Nakamura R, Zhang MJ, Atallah E, Rizzo JD, Maziarz RT, Cortes J, Kalaycio ME, Horowitz MM. Impact of donor source on hematopoietic cell transplantation outcomes for patients with myelodysplastic syndromes (MDS). Blood. 2013 Sep 12;122(11):1974-82. doi: 10.1182/blood-2013-04-496778. Epub 2013 Jul 11.PMID:23847196

Costa LJ, Zhang MJ, Zhong X, Dispenzieri A, Lonial S, Krishnan A, Freytes C, Vesole D, Gale RP, Anderson K, Wirk B, Savani BN, Waller EK, Schouten H, Lazarus H, Meehan K, Sharma M, Kamble R, Vij R, Kumar S, Nishihori T, Kindwall-Keller T, Saber W, Hari PN Trends in utilization and outcomes of autologous transplantation as early therapy for multiple myeloma.Biol Blood Marrow Transplant. 2013 Nov;19(11):1615-24. doi: 10.1016/j.bbmt.2013.08.002. Epub 2013 Aug 11.PMID:23939198

Pidala J, Wang T, Haagenson M, Spellman SR, Askar M, Battiwalla M, Baxter-Lowe LA, Bitan M, Fernandez-Viña M, Gandhi M, Jakubowski AA, Maiers M, Marino SR, Marsh SG, Oudshoorn M, Palmer J, Prasad VK, Reddy V, Ringden O, Saber W, Santarone S, Schultz KR, Setterholm M, Trachtenberg E, Turner EV, Woolfrey AE, Lee SJ, Anasetti C. Amino acid substitution at peptide-binding pockets of HLA class I molecules increases risk of severe acute GVHD and mortality. Blood. 2013 Nov 21;122(22):3651-8. doi: 10.1182/blood-2013-05-501510. Epub 2013 Aug 27.PMID:23982174

Bachanova V, Marks DI, Zhang MJ, Wang H, de Lima M, Aljurf MD, Arellano M, Artz AS, Bacher U, Cahn JY, Chen YB, Copelan EA, Drobyski WR, Gale RP, Greer JP, Gupta V, Hale GA, Kebriaei P, Lazarus HM, Lewis ID, Lewis VA, Liesveld JL, Litzow MR, Loren AW, Miller AM, Norkin M, Oran B, Pidala J, Rowe JM, Savani BN, Saber W, Vij R, Waller EK, Wiernik PH, Weisdorf DJ.Ph+ ALL patients in first complete remission have similar survival after reduced intensity and myeloablative allogeneic transplantation: impact of tyrosine kinase inhibitor and minimal residual disease. Leukemia. 2014 Mar;28(3):658-65. doi: 10.1038/leu.2013.253. Epub 2013 Aug 30.PMID:23989431

Copelan EA, Hamilton BK, Avalos B, Ahn KW, Bolwell BJ, Zhu X, Aljurf M, van Besien K, Bredeson C, Cahn JY, Costa LJ, de Lima M, Gale RP, Hale GA, Halter J, Hamadani M, Inamoto Y, Kamble RT, Litzow MR, Loren AW, Marks DI, Olavarria E, Roy V, Sabloff M, Savani BN, Seftel M, Schouten HC, Ustun C, Waller EK, Weisdorf DJ, Wirk B, Horowitz MM, Arora M, Szer J, Cortes J, Kalaycio ME, Maziarz RT, Saber W.Better leukemia-free and overall survival in AML in first remission following cyclophosphamide in combination with busulfan compared with TBI. Blood. 2013 Dec 5;122(24):3863-70. doi: 10.1182/blood-2013-07-514448. Epub 2013 Sep 24.PMID:24065243

Gupta V, Malone AK, Hari PN, Ahn KW, Hu ZH, Gale RP, Ballen KK, Hamadani M, Olavarria E, Gerds AT, Waller EK, Costa LJ, Antin JH, Kamble RT, van Besien KM, Savani BN, Schouten HC, Szer J, Cahn JY, de Lima MJ, Wirk B, Aljurf MD, Popat U, Bejanyan N, Litzow MR, Norkin M, Lewis ID, Hale GA, Woolfrey AE, Miller AM, Ustun C, Jagasia MH, Lill M, Maziarz RT, Cortes J, Kalaycio ME, Saber W.Reduced-intensity hematopoietic cell transplantation for patients with primary myelofibrosis: a cohort analysis from the center for international blood and marrow transplant research. Biol Blood Marrow Transplant. 2014 Jan;20(1):89-97. doi: 10.1016/j.bbmt.2013.10.018. Epub 2013 Oct 23.PMID:24161923

Warlick ED, Paulson K, Brazauskas R, Zhong X, Miller AM, Camitta BM, George B, Savani BN, Ustun C, Marks DI, Waller EK, Baron F, Freytes CO, Socie G, Akpek G, Schouten HC, Lazarus HM, Horwitz EM, Koreth J, Cahn JY, Bornhauser M, Seftel M, Cairo MS, Laughlin MJ, Sabloff M, Ringdén O, Gale RP, Kamble RT, Vij R, Gergis U, Mathews V, Saber W, Chen YB, Liesveld JL, Cutler CS, Ghobadi A, Uy GL, Eapen M, Weisdorf DJ, Litzow MR.Effect of postremission therapy before reduced-intensity conditioning allogeneic transplantation for acute myeloid leukemia in first complete remission. Biol Blood Marrow Transplant. 2014 Feb;20(2):202-8. doi: 10.1016/j.bbmt.2013.10.023. Epub 2013 Nov 1.PMID:24184335

Sabloff M, Sobecks RM, Ahn KW, Zhu X, de Lima M, Brown JR, Inamoto Y, Holland HK, Aljurf MD, Laughlin MJ, Kamble RT, Hsu JW, Wirk BM, Seftel M, Lewis ID, Arora M, Alyea EP, Kalaycio ME, Cortes J, Maziarz RT, Gale RP, Saber W. Does total body irradiation conditioning improve outcomes of myeloablative human leukocyte antigen-identical sibling transplantations for chronic lymphocytic leukemia? Biol Blood Marrow Transplant. 2014 Mar;20(3):421-4. doi: 10.1016/j.bbmt.2013.11.032. Epub 2013 Dec 7.PMID:24321745

Saad A, Mahindra A, Zhang MJ, Zhong X, Costa LJ, Dispenzieri A, Drobyski WR, Freytes CO, Gale RP, Gasparetto CJ, Holmberg LA, Kamble RT, Krishnan AY, Kyle RA, Marks D, Nishihori T, Pasquini MC, Ramanathan M, Lonial S, Savani BN, Saber W, Sharma M, Sorror ML, Wirk BM, Hari PN. Hematopoietic cell transplant comorbidity index is predictive of survival after autologous hematopoietic cell transplantation in multiple myeloma. Biol Blood Marrow Transplant. 2014 Mar;20(3):402-408.e1. doi: 10.1016/j.bbmt.2013.12.557. Epub 2013 Dec 14.PMID:24342394

Atallah E, Bylow K, Troy J, Saber W. Treatment of older patients with high-risk myelodysplastic syndromes (MDS): the emerging role of allogeneic hematopoietic stem cell transplantation (Allo HSCT). Curr Hematol Malig Rep. 2014 Mar;9(1):57-65. doi: 10.1007/s11899-013-0195-9.PMID:24398726

Wirk B, Fenske TS, Hamadani M, Zhang MJ, Hu ZH, Akpek G, Aljurf MD, Armand P, Ayala E, Bachanova V, Bolwell B, Cairo MS, Cashen A, Chen YB, Costa LJ, Farhan S, Freytes CO, Gajewski JL, Gibson J, Hale GA, Holmberg LA, Hsu JW, Inwards DJ, Kamble RT, Maharaj D, Maziarz RT, Munker R, Nath R, Reddy NM, Reeder CB, Rizzieri DA, Sauter CS, Savani BN, Schouten HC, Sureda A, Vose JM, Waller EK, Wiernik PH, Gale RP, Burns LJ, Saber W. Outcomes of Hematopoietic Cell Transplantation for Diffuse Large B Cell Lymphoma Transformed from Follicular Lymphoma. Biol Blood Marrow Transplant. 2014 Mar 15. pii: S1083-8791(14)00163-3. doi: 10.1016/j.bbmt.2014.03.014. [Epub ahead of print]PMID:24641828

McClune BL, Ahn KW, Wang HL, Antin JH, Artz AS, Cahn JY, Deol A, Freytes CO, Hamadani M, Holmberg LA, Jagasia MH, Jakubowski AA, Kharfan-Dabaja MA, Lazarus HM, Miller AM, Olsson R, Pedersen TL, Pidala J, Pulsipher MA, Rowe JM, Saber W, van Besien KW, Waller EK, Aljurf MD, Akpek G, Bacher U, Chao NJ, Chen YB, Cooper BW, Dehn J, de Lima MJ, Hsu JW, Lewis ID, Marks DI, McGuirk J, Cairo MS, Schouten HC, Szer J, Ramanathan M, Savani BN, Seftel M, Socie G, Vij R, Warlick ED, Weisdorf DJ. Allotransplantation for Patients Age ≥40 Years with Non-Hodgkin Lymphoma: Encouraging Progression-Free Survival. Biol Blood Marrow Transplant. 2014 Mar 15. pii: S1083-8791(14)00162-1. doi: 10.1016/j.bbmt.2014.03.013. [Epub ahead of print]PMID:24641829

Armand P, Kim HT, Logan BR, Wang Z, Alyea EP, Kalaycio ME, Maziarz RT, Antin JH, Soiffer RJ, Weisdorf DJ, Rizzo JD, Horowitz MM, Saber W. Validation and refinement of the Disease Risk Index for allogeneic stem cell transplantation. Blood. 2014 Jun 5;123(23):3664-71. doi: 10.1182/blood-2014-01-552984. Epub 2014 Apr 17.PMID:24744269

Sobecks RM, Leis JF, Gale RP, Ahn KW, Zhu X, Sabloff M, de Lima M, Brown JR, Inamoto Y, Hale GA, Aljurf MD, Kamble RT, Hsu JW, Pavletic SZ, Wirk B, Seftel MD, Lewis ID, Alyea EP, Cortes J, Kalaycio ME, Maziarz RT, Saber W. Outcomes of human leukocyte antigen-matched sibling donor hematopoietic cell transplantation in chronic lymphocytic leukemia: myeloablative versus reduced-intensity conditioning regimens. Biol Blood Marrow Transplant. 2014 May 28. pii: S1083-8791(14)00318-8. doi: 10.1016/j.bbmt.2014.05.020. [Epub ahead of print] PMID: 24880021

Saber W, Le Rademacher J, Sekeres M, Logan B, Lewis M, Mendizabal A, Leifer E, Appelbaum FR, Horowitz MM, Nakamura R, Cutler CS. Multicenter biologic assignment trial comparing reduced-intensity allogeneic hematopoietic cell transplant to hypomethylating therapy or best supportive care in patients aged 50 to 75 with intermediate-2 and high-risk myelodysplastic syndrome: blood and marrow transplant clinical trials network #1102 study rationale, design, and methods. Biol Blood Marrow Transplant. 2014 Oct;20(10):1566-72. doi: 10.1016/j.bbmt.2014.06.010. Epub 2014 Jun 24. PMID:24972249

Hamadani M, Hari PN, Zhang Y, Carreras J, Akpek G, Aljurf MD, Ayala E, Bachanova V, Chen AI, Chen YB, Costa LJ, Fenske TS, Freytes CO, Ganguly S, Hertzberg MS, Holmberg LA, Inwards DJ, Kamble RT, Kanfer EJ, Lazarus HM, Marks DI, Nishihori T, Olsson R, Reddy NM, Rizzieri DA, Savani BN, Solh M, Vose JM, Wirk B, Maloney DG, Smith SM, Montoto S, Saber W. Early Failure of Frontline Rituximab-Containing Chemo-immunotherapy in Diffuse Large B Cell Lymphoma Does Not Predict Futility of Autologous Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2014 Jul 5. pii: S1083-8791(14)00403-0. doi: 10.1016/j.bbmt.2014.06.036. [Epub ahead of print] PMID:25008330

Ringdén O, Brazauskas R, Wang Z, Ahmed I, Atsuta Y, Buchbinder D, Burns LJ, Cahn JY, Duncan C, Hale GA, Halter J, Hayashi RJ, Hsu JW, Jacobsohn DA, Kamble RT, Kamani NR, Kasow KA, Khera N, Lazarus HM, Loren AW, Marks DI, Myers KC, Ramanathan M, Saber W, Savani BN, Schouten HC, Socie G, Sorror ML, Steinberg A, Popat U, Wingard JR, Mattsson J, Majhail NS. Second Solid Cancers after Allogeneic Hematopoietic Cell Transplantation Using Reduced-Intensity Conditioning. Biol Blood Marrow Transplant. 2014 Jul 17. pii: S1083-8791(14)00435-2. doi: 10.1016/j.bbmt.2014.07.009. [Epub ahead of print] PMID:25042734

Dhakal B, Strouse C, D'Souza A, Arce-Lara C, Esselman J, Eastwood D, Pasquini M, Saber W, Drobyski W, Rizzo JD, Hari PN, Hamadani M. Plerixafor and Abbreviated-Course Granulocyte Colony-Stimulating Factor for Mobilizing Hematopoietic Progenitor Cells in Light Chain Amyloidosis. Biol Blood Marrow Transplant. 2014 Aug 8. pii: S1083-8791(14)00501-1. doi: 10.1016/j.bbmt.2014.08.002. [Epub ahead of print] PMID:25154823

Ustun C, Reiter A, Scott BL, Nakamura R, Damaj G, Kreil S, Shanley R, Hogan WJ, Perales MA, Shore T, Baurmann H, Stuart R, Gruhn B, Doubek M, Hsu JW, Tholouli E, Gromke T, Godley LA, Pagano L, Gilman A, Wagner EM, Shwayder T, Bornhäuser M, Papadopoulos EB, Böhm A, Vercellotti G, Van Lint MT, Schmid C, Rabitsch W, Pullarkat V, Legrand F, Yakoub-Agha I, Saber W, Barrett J, Hermine O, Hagglund H, Sperr WR, Popat U, Alyea EP, Devine S, Deeg HJ, Weisdorf D, Akin C, Valent P. Hematopoietic Stem-Cell Transplantation for Advanced Systemic Mastocytosis. J Clin Oncol. 2014 Aug 25. pii: JCO.2014.55.2018. [Epub ahead of print] PMID:25154823

Pidala J, Lee SJ, Ahn KW, Spellman S, Wang HL, Aljurf M, Askar M, Dehn J, Fernandez Viña M, Gratwohl A, Gupta V, Hanna R, Horowitz MM, Hurley CK, Inamoto Y, Kassim AA, Nishihori T, Mueller C, Oudshoorn M, Petersdorf EW, Prasad V, Robinson J, Saber W, Schultz KR, Shaw B, Storek J, Wood WA, Woolfrey AE, Anasetti C. Non-permissive -DPB1 mismatch among otherwise HLA-matched donor-recipient pairs results in increased overall mortality after myeloablative unrelated allogeneic hematopoietic cell transplantation for hematologic malignancies. Blood. 2014 Aug 26. pii: blood-2014-05-576041. [Epub ahead of print] PMID:25161269

El-Naggar Nel-A, Abdelwahed NA, Saber WI, Mohamed AA. Bioprocessing of some agro-industrial residues for endoglucanase production by the new subsp.; Streptomyces albogriseolus subsp. cellulolyticus strain NEAE-J. Braz J Microbiol. 2014 Aug 29;45(2):743-56. eCollection 2014.PMID:25242966

Duncan CN, Majhail NS, Brazauskas R, Wang Z, Cahn JY, Frangoul HA, Hayashi RJ, Hsu JW, Kamble RT, Kasow KA, Khera N, Lazarus HM, Loren AW, Marks DI, Maziarz RT, Mehta P, Myers KC, Norkin M, Pidala JA, Porter DL, Reddy V, Saber W, Savani BN, Schouten HC, Steinberg A, Wall DA, Warwick AB, Wood WA, Yu LC, Jacobsohn DA, Sorror ML. Long-term survival and late effects among one-year survivors of second allogeneic hematopoietic cell transplantation for relapsed acute leukemia and myelodysplastic syndromes. Biol Blood Marrow Transplant. 2015 Jan;21(1):151-8. doi: 10.1016/j.bbmt.2014.10.006. Epub 2014 Oct 12. PMID:25316109

Bachanova V, Burns LJ, Wang T, Carreras J, Gale RP, Wiernik PH, Ballen KK, Wirk B, Munker R, Rizzieri DA, Chen YB, Gibson J, Akpek G, Costa LJ, Kamble RT, Aljurf MD, Hsu JW, Cairo MS, Schouten HC, Bacher U, Savani BN, Wingard JR, Lazarus HM, Laport GG, Montoto S, Maloney DG, Smith SM, Brunstein C, Saber W. Alternative donors extend transplantation for patients with lymphoma who lack an HLA matched donor. Bone Marrow Transplant. 2015 Feb;50(2):197-203. doi: 10.1038/bmt.2014.259. Epub 2014 Nov 17. PMID:25402415

Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJ. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. >Nat Neurosci. 2015 Jan;18(1):17-24. doi: 10.1038/nn.3886. Epub 2014 Nov 24.PMID:25420066

Arai S, Arora M, Wang T, Spellman SR, He W, Couriel DR, Urbano-Ispizua A, Cutler CS, Bacigalupo AA, Battiwalla M, Flowers ME, Juckett MB, Lee SJ, Loren AW, Klumpp TR, Prockup SE, Ringdén OT, Savani BN, Socié G, Schultz KR, Spitzer T, Teshima T, Bredeson CN, Jacobsohn DA, Hayashi RJ, Drobyski WR, Frangoul HA, Akpek G, Ho VT, Lewis VA, Gale RP, Koreth J, Chao NJ, Aljurf MD, Cooper BW, Laughlin MJ, Hsu JW, Hematti P, Verdonck LF, Solh MM, Norkin M, Reddy V, Martino R, Gadalla S, Goldberg JD, McCarthy PL, Pérez-Simón JA, Khera N, Lewis ID, Atsuta Y, Olsson RF, Saber W, Waller EK, Blaise D, Pidala JA, Martin PJ, Satwani P, Bornhäuser M, Inamoto Y, Weisdorf DJ, Horowitz MM, Pavletic SZ; Graft-vs-Host Disease Working Committee of the CIBMTR. Increasing incidence of chronic graft-versus-host disease in allogeneic transplantation: a report from the Center for International Blood and Marrow Transplant Research. Biol Blood Marrow Transplant. 2015 Feb;21(2):266-74. doi: 10.1016/j.bbmt.2014.10.021. Epub 2014 Oct 30. PMID: 25445023

Copelan EA, Avalos BR, Ahn KW, Zhu X, Gale RP, Grunwald MR, Hamadani M, Hamilton BK, Hale GA, Marks DI, Waller EK, Savani BN, Costa LJ, Ramanathan M, Cahn JY, Khoury HJ, Weisdorf DJ, Inamoto Y, Kamble RT, Schouten HC, Wirk B, Litzow MR, Aljurf MD, van Besien KW, Ustun C, Bolwell BJ, Bredeson CN, Fasan O, Ghosh N, Horowitz MM, Arora M, Szer J, Loren AW, Alyea EP, Cortes J, Maziarz RT, Kalaycio ME, Saber W. Comparison of outcomes of allogeneic transplantation for chronic myeloid leukemia with cyclophosphamide in combination with intravenous busulfan, oral busulfan, or total body irradiation. Biol Blood Marrow Transplant. 2015 Mar;21(3):552-8. doi: 10.1016/j.bbmt.2014.12.010. Epub 2014 Dec 17. PMID: 25528388

Mahindra A, Raval G, Mehta P, Brazauskas R, Zhang MJ, Zhong X, Bird JM, Freytes CO, Hale GA, Herzig R, Holmberg LA, Kamble RT, Kumar S, Lazarus HM, Majhail NS, Marks DI, Moreb JS, Olsson R, Saber W, Savani BN, Schiller GJ, Tay J, Vogl DT, Waller EK, Wiernik PH, Wirk B, Lonial S, Krishnan AY, Dispenzieri A, Brandenburg NA, Gale RP, Hari PN. New cancers after autotransplantations for multiple myeloma. Biol Blood Marrow Transplant. 2015 Apr;21(4):738-45. doi: 10.1016/j.bbmt.2014.12.028. Epub 2014 Dec 31. PMID:25555448

Dhakal B, D'Souza A, Arce-Lara C, Pasquini M, Saber W, Falvo F, Esselman J, Zellner K, Fenske T, Hari PN, Hamadani M. Superior efficacy but higher cost of plerixafor and abbreviated-course G-CSF for mobilizing hematopoietic progenitor cells (HPC) in AL amyloidosis. Bone Marrow Transplant. 2015 Apr;50(4):610-2. doi: 10.1038/bmt.2014.318. Epub 2015 Jan 26. No abstract available.PMID:25621807

Majhail NS, Giralt S, Bonagura A, Crawford S, Farnia S, Omel JL, Pasquini M, Saber W, LeMaistre CF. Guidelines for defining and implementing standard episode of care for hematopoietic stem cell transplantation within the context of clinical trials. Biol Blood Marrow Transplant. 2015 Apr;21(4):583-8. doi: 10.1016/j.bbmt.2014.12.030. Epub 2015 Jan 29.PMID:25639771

Chen YB, Lane AA, Logan BR, Zhu X, Akpek G, Aljurf MD, Artz AS, Bredeson CN, Cooke KR, Ho VT, Lazarus HM, Olsson RF, Saber W, McCarthy PL, Pasquini MC. Impact of conditioning regimen on outcomes for patients with lymphoma undergoing high-dose therapy with autologous hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2015 Jun;21(6):1046-53. doi: 10.1016/j.bbmt.2015.02.005. Epub 2015 Feb 14. PMID:25687795

Ibrahim N, Hasanin A, Allah SA, Sayed E, Afifi M, Yassen K, Saber W, Khalil M. The haemodynamic effects of the perioperative terlipressin infusion in living donor liver transplantation: A randomised controlled study. Indian J Anaesth. 2015 Mar;59(3):156-64. doi: 10.4103/0019-5049.153037. PMID: 25838587

Graff TM, Singavi AK, Schmidt W, Eastwood D, Drobyski WR, Horowitz M, Palmer J, Pasquini M, Rizzo DJ, Saber W, Hari P, Fenske TS. Safety of outpatient autologous hematopoietic cell transplantation for multiple myeloma and lymphoma. Bone Marrow Transplant. 2015 Jul;50(7):947-53. doi: 10.1038/bmt.2015.46. Epub 2015 Apr 13. PMID: 25867651

Goyal SD, Zhang MJ, Wang HL, Akpek G, Copelan EA, Freytes C, Gale RP, Hamadani M, Inamoto Y, Kamble RT, Lazarus HM, Marks DI, Nishihori T, Olsson RF, Reshef R, Ritchie DS, Saber W, Savani BN, Seber A, Shea TC, Tallman MS, Wirk B, Bunjes DW, Devine SM, de Lima M, Weisdorf DJ, Uy GL. Allogeneic hematopoietic cell transplant for AML: no impact of pre-transplant extramedullary disease on outcome. Bone Marrow Transplant. 2015 Aug;50(8):1057-62. doi: 10.1038/bmt.2015.82. Epub 2015 Apr 27. PMID:25915806

Cornell RF, Zhong X, Arce-Lara C, Atallah E, Blust L, Drobyski WR, Fenske TS, Pasquini MC, Rizzo JD, Saber W, Hari PN. Bortezomib-based induction for transplant ineligible AL amyloidosis and feasibility of later transplantation. Bone Marrow Transplant. 2015 Jul;50(7):914-7. doi: 10.1038/bmt.2015.73. Epub 2015 Apr 27. PMID:25915809

Urbano-Ispizua A, Pavletic SZ, Flowers ME, Klein JP, Zhang MJ, Carreras J, Montoto S, Perales MA, Aljurf MD, Akpek G, Bredeson CN, Costa LJ, Dandoy C, Freytes CO, Fung HC, Gale RP, Gibson J, Hamadani M, Hayashi RJ, Inamoto Y, Inwards DJ, Lazarus HM, Maloney DG, Martino R, Munker R, Nishihori T, Olsson RF, Rizzieri DA, Reshef R, Saad A, Savani BN, Schouten HC, Smith SM, Socié G, Wirk B, Yu LC, Saber W. The Impact of Graft-versus-Host Disease on the Relapse Rate in Patients with Lymphoma Depends on the Histological Subtype and the Intensity of the Conditioning Regimen. Biol Blood Marrow Transplant. 2015 May 15. pii: S1083-8791(15)00333-X. doi: 10.1016/j.bbmt.2015.05.010. [Epub ahead of print] PMID:25981509

Verneris MR, Lee SJ, Ahn KW, Wang HL, Battiwalla M, Inamoto Y, Fernandez-Vina MA, Gajewski J, Pidala J, Munker R, Aljurf M, Saber W, Spellman S, Koreth J. HLA Mismatch Is Associated with Worse Outcomes after Unrelated Donor Reduced-Intensity Conditioning Hematopoietic Cell Transplantation: An Analysis from the Center for International Blood and Marrow Transplant Research. Biol Blood Marrow Transplant. 2015 Jun 6. pii: S1083-8791(15)00389-4. doi: 10.1016/j.bbmt.2015.05.028. [Epub ahead of print] PMID: 26055300

El-Mazny A, Abou-Salem N, Hammam M, Saber W. Hysteroscopic tubal electrocoagulation versus laparoscopic tubal ligation for patients with hydrosalpinges undergoing in vitro fertilization. Int J Gynaecol Obstet. 2015 Jun 30. pii: S0020-7292(15)00399-9. doi: 10.1016/j.ijgo.2015.04.039. [Epub ahead of print] PMID: 26140948

Vierthaler L, Callas PW, Goodney PP, Schanzer A, Patel VI, Cronenwett J, Bertges DJ; Vascular Study Group of New England. Determinants of survival and major amputation after peripheral endovascular intervention for critical limb ischemia. J Vasc Surg. 2015 Jul 24. pii: S0741-5214(15)00906-4. doi: 10.1016/j.jvs.2015.04.391. [Epub ahead of print] PMID: 26215708

Majhail NS, Farnia SH, Carpenter PA, Champlin RE, Crawford S, Marks DI, Omel JL, Orchard PJ, Palmer J, Saber W, Savani BN, Veys PA, Bredeson CN, Giralt SA, LeMaistre CF. Indications for Autologous and Allogeneic Hematopoietic Cell Transplantation: Guidelines from the American Society for Blood and Marrow Transplantation. Biol Blood Marrow Transplant. 2015 Aug 6. pii: S1083-8791(15)00512-1. doi: 10.1016/j.bbmt.2015.07.032. [Epub ahead of print] PMID:26256941

Suwanabol, Pasithorn (Amy)
Mentor: Kent, K. Craig
Years in RTH T32 Program: 2009-2011

Recent Publications:

Suwanabol PA, McDonald R, Foley E, Weber SM. Is Surgical Resident Comfort Associated with Experience? J Surg Res. 2009 Oct; 156(2)240-4. PMID: 19631338. PMCID: Policy Exempt- Not resulting from NIH funding.

Zhang F, Banker G, Liu X, Suwanabol PA, Lengfeld J, Yamanouchi D, Kent KC, Liu B. The novel function of advanced glycation end products in regulation of MMP-9 production. J Surg Res. 2011 Dec;171(2):871-6. doi: 10.1016/j.jss.2010.04.027. Epub 2010 May 11.PMID:20638679 PMCID: Policy Exempt - Not resulting from NIH funding.

Suwanabol PA, Tefera G, Schwarze ML. Syndromes associated with the deep veins: phlegmasia cerulean dolens, May-Thurner syndrome, and nutcracker syndrome. Perspect Vasc Surg Endovasc Ther. 2010 Dec;22(4):223-30. PMID: 21411461. PMCID: Policy Exempt - Not resulting from NIH funding.

Suwanabol PA, Kent KC, Liu B. TGF-β and restenosis revisited: a Smad link. J Surg Res. 2011 May 15;167(2)287-97. PMCID: PMC3077463.

Mazeh H, Suwanabol PA, Schneider DF, Sippel RS. Late manifestation of tracheal rupture after thyroidectomy: case report and literature review. Endocr Pract. 2012 Jul-Aug;18(4):e73-6. doi: 10.4158/EP11344.CR. Review.PMID:22297061

Suwanabol PA, Seedial SM, Zhang F, Shi X, Si Y, Liu B, Kent KC. TGF-β and Smad3 modulate PI3K/Akt signaling pathway in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2012 Jun 1;302(11):H2211-9. doi: 10.1152/ajpheart.00966.2011. Epub 2012 Mar 23.PMID:22447946

Suwanabol PA, Seedial SM, Shi X, Zhang F, Yamanouchi D, Roenneburg D, Liu B, Kent KC. Transforming growth factor-β increases vascular smooth muscle cell proliferation through the Smad3 and extracellular signal-regulated kinase mitogen-activated protein kinases pathways. J Vasc Surg. 2012 Aug;56(2):446-54. doi: 10.1016/j.jvs.2011.12.038. Epub 2012 Apr 21.PMID:22521802

Seedial SM, Ghosh S, Saunders RS, Suwanabol PA, Shi X, Liu B, Kent KC. Local drug delivery to prevent restenosis. J Vasc Surg. 2013 May;57(5):1403-14. doi: 10.1016/j.jvs.2012.12.069. Review.PMID:23601595

Bobadilla JL, Suwanabol PA, Reeder SB, Pozniak MA, Bley TA, Tefera G. Clinical implications of non-contrast-enhanced computed tomography for follow-up after endovascular abdominal aortic aneurysm repair. Ann Vasc Surg. 2013 Nov;27(8):1042-8. doi: 10.1016/j.avsg.2012.10.021. Epub 2013 May 24.PMID:23711975

Suwanabol PA, Hoch JR. Venous thromboembolic disease. Surg Clin North Am. 2013 Aug;93(4):983-95, x. doi: 10.1016/j.suc.2013.05.003. Review. PMID:23885941

Shi X, Guo LW, Seedial SM, Si Y, Wang B, Takayama T, Suwanabol PA, Ghosh S, DiRenzo D, Liu B, Kent KC. TGF-β/Smad3 inhibit vascular smooth muscle cell apoptosis through an autocrine signaling mechanism involving VEGF-A. Cell Death Dis. 2014 Jul 10;5:e1317. doi: 10.1038/cddis.2014.282. PMID:25010983

Hanzlik TP, Tevis SE, Suwanabol PA, Carchman EH, Harms BA, Heise CP, Foley EF, Kennedy GD. Characterizing readmission in ulcerative colitis patients undergoing restorative proctocolectomy. J Gastrointest Surg. 2015 Mar;19(3):564-9. doi: 10.1007/s11605-014-2734-7. Epub 2015 Jan 6. PMID:25560185

Shelef, Miriam
Mentor: Huttenlocher, Anna
Years in RTH T32 Program: 2009-2011

Recent Publications:

Omori SA, Cato MH, Anzelon-Mills A, Puri KD, Shapiro-Shelef M, Calame K, and Rickert RC. Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling. Immunity. 2006 Oct;25(4):545-57 PMID: 17000121

Martins GA, Cimmino L, Shapiro-Shelef M, Szabolcs M, Herron A, Magnusdottir E, Calame K. Transcriptional repressor Blimp-1 regulates T cell homeostasis and function. Nat Immunol. 2006 May;7(5):457-65. PMID: 16565721

Shelef MA, Bennin DA, Mosher DF, Huttenlocher A. Citrullination of fibronectin modulates synovial fibroblast behavior. Arthritis Res Ther. 2012 Nov 5;14(6):R240. [Epub ahead of print] PMID: 23127210

Sackmann EK, Berthier E, Young EW, Shelef MA, Wernimont SA, Huttenlocher A, Beebe DJ. Microfluidic kit-on-a-lid: a versatile platform for neutrophil chemotaxis assays. Blood. 2012 Oct 4;120(14):e45-53. doi: 10.1182/blood-2012-03-416453. Epub 2012 Aug 22. PMID: 22915642

Shelef MA, Tauzin S, Huttenlocher A. Neutrophil migration: moving from zebrafish models to human autoimmunity. Immunol Rev. 2013 Nov;256(1):269-81. doi: 10.1111/imr.12124. Review.PMID:24117827

Shelef MA, Sokolove J, Lahey LJ, Wagner CA, Sackmann EK, Warner TF, Wang Y, Beebe DJ, Robinson WH, Huttenlocher A .Peptidylarginine Deiminase 4 Contributes to Tumor Necrosis Factor α-Induced Inflammatory Arthritis. Arthritis Rheumatol. 2014 Jun;66(6):1482-91. doi: 10.1002/art.38393.PMID:24497204

Shelef MA, Sokolove J, Robinson WH, Huttenlocher A. Reply. Arthritis Rheumatol. 2014 May 28. doi: 10.1002/art.38722. [Epub ahead of print] No abstract available.PMID:24891318

Shelef MA, Bennin DA, Yasmin N, Warner TF, Ludwig T, Beggs HE, Huttenlocher A. Focal adhesion kinase is required for synovial fibroblast invasion, but not murine inflammatory arthritis. Arthritis Res Ther. 2014 Oct 4;16(5):464. doi: 10.1186/s13075-014-0464-6. PMID: 25280866

Settles, Erik
Mentor: Knoll, Laura
Years in RTH T32 Program: 2010-2012

Recent Publications:

Kopek BG, Settles EW, Friesen PD, Ahlquist P. J Nodavirus-induced membrane rearrangement in replication complex assembly requires replicase protein a, RNA templates, and polymerase activity. Virol. 2010 Dec;84(24):12492-503. Epub 2010 Oct 13. PMCID: PMC3004334

Jones JC, Settles EW, Brandt CR, Schultz-Cherry S. Identification of the minimal active sequence of an anti-influenza virus peptide. Antimicrob Agents Chemother. 2011 Apr;55(4):1810-3. Epub 2011 Jan 10. PMCID: PMC3067171

Jones JC, Settles EW, Brandt CR, Schultz-Cherry S. Virus aggregating peptide enhances the cell-mediated response to influenza virus vaccine. Vaccine. 2011 Oct 13;29(44):7696-703. Epub 2011 Aug 10. PMCID: PMC3190079

Settles EW, Moser LA, Harris TH, Knoll LJ. Toxoplasma gondii upregulates interleukin-12 to prevent Plasmodium berghei-induced experimental cerebral malaria. Infect Immun. 2014 Mar;82(3):1343-53. doi: 10.1128/IAI.01259-13. Epub 2014 Jan 6.PMID:24396042

Settles EW, Kink JA, Talaat A. Attenuated strains of Mycobacterium avium subspecies paratuberculosis as vaccine candidates against Johne's disease. Vaccine. 2014 Apr 11;32(18):2062-9. doi: 10.1016/j.vaccine.2014.02.010. Epub 2014 Feb 22.PMID:24565753

Dvorak, Andrea
Mentors: Fost, Norman and Sondel, Paul
Years in RTH T32 Program: 2010-2012

Recent Publications:


Dvorak A, Protts BB "Effects of chromium piccolinate (CP) on insulin levels and Morris water maze performance in rats [Abstract]." The Ohio Journal of Science. 2001; 101: A-23.

Dvorak A, Pritt, BB. "Effects of Phenylpropanolamine (PPA) on behavior, protein levels, and reproductive hormones in young male rats [Abstract]." The Ohio Journal of Science. 2002; 102:A-7

Fletcher, Christopher
Mentor: Kahl
Years in RTH T32 Program:2011-2013

Fletcher CD, Kahl BS. Central nervous system involvement in diffuse large B-cell lymphoma: an analysis of risks and prevention strategies in the post-rituximab era. Leuk Lymphoma. 2014 Feb 24. [Epub ahead of print]PMID:24286262

Wolfe, Adam D.
Mentor: Downs, Karen and Sondel, Paul
Years in RTH T32 Program: 2012-2014

Wolfe AD, Downs KM. Mixl1 localizes to putative axial stem cell reservoirs and their posterior descendants in the mouse embryo. Gene Expr Patterns. 2014 May;15(1):8-20. doi: 10.1016/j.gep.2014.02.002. Epub 2014 Mar 12. PMID: 24632399 PMCID: PMC4065840

Wolfe AD, Frierdich SA, Wish J, Kilgore-Carlin J, Plotkin JA, Hoover-Regan M. Sharing life-altering information: development of pediatric hospital guidelines and team training.J Palliat Med. 2014 Sep;17(9):1011-8 Epub 2014 Jun 27 PMID: 24971650 PMCID: PMC4158952 

Wolfe AD, Rodriguez AM, Downs KM. STELLA collaborates in distinct mesendodermal cell subpopulations at the fetal-placental interface in the mouse gastrula. Dev Biol.2017 May1;425(1):44-57. doi: 10.1016/j.ydbio.2017.03.014. Epub 2017 Mar 18 PMID 28322725 PMCID: PMC5510028

Wolfe AD, Capitini CM, Salamat SM, DeSantes K, Bradley KA, Kennedy T, Dehner LP, Patel NJ. Neck rhabdoid tumors: Clinical features and consideration of autologous stem cell transplant. J Pediatr Hematol Oncol. 2018 Jan; 40(1):e50-e54. doi:10.1097/MPH.0000000000000829. PMID: 28375943 PMCID: PMC5624815

Rodriguez AM, Jin Dx, Wolfe AD, Mikedis MM, Wierenga L, Hashmi MP, Viebahn C, Downs KM. Brachyury drives formation of a distinct vascular branchpoint critical for fetal-placement arterial union in the mouse gastrula. Dev Biol. 2017 May 15;425(2):208-222. doi:10.1016?j.ydbio.2017.03.032. Epub 2017 Apr 4. PMID 28389228. PMCID: PMC5760991

Hewitt, Kyle
Mentor: Bresnick, Emery
Years in RTH T32 Programs:2012-2014

Sanalkumar R, Johnson KD, Gao X, Boyer ME, Chang YI, Hewitt KJ, Zhang J, Bresnick EH. Mechanism governing a stem cell-generating cis-regulatory element. Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):E1091-100. doi: 10.1073/pnas.1400065111. Epub 2014 Mar 10.PMID:24616499

Hewitt KJ, Sanalkumar R, Johnson KD, Keles S, Bresnick EH. Epigenetic and genetic mechanisms in red cell biology. Curr Opin Hematol. 2014 May;21(3):155-64. doi: 10.1097/MOH.0000000000000034. PMID:24722192

Hewitt KJ, Kim DH, Devadas P, Prathibha R, Zuo C, Sanalkumar R, Johnson KD, Kang YA, Kim JS, Dewey CN, Keles S, Bresnick EH. Hematopoietic Signaling Mechanism Revealed from a Stem/Progenitor Cell Cistrome. Mol Cell. 2015 Jul 2;59(1):62-74. doi: 10.1016/j.molcel.2015.05.020. Epub 2015 Jun 11. PMID: 26073540 PMCID: PMC4499333

Chanakira, Alice
Mentor: Sheehan, John P
Years in TRH T32 Program:2012-2015

Chanakira A, Chikwana E, Peyton H. D and Simoyi R. 2004. Kinetics and mechanism of the oxidation of cysteamine by acidic iodate and iodine. Can. J. Chem. 84(1): 49–57

Chanakira A, Barke R, Dutta R, Charboneau R Santilli S.M and Roy S. Hypoxic Endothelial Cell Conditioned Media Induces Arterial Derived Smooth Muscle Cell (SMC) Proliferation via a PDGF-BB Dependent and a VEGF-A Independent Mechanism. AHA: ATVB Abstract April 2010

Chanakira A, Dutta R, Charboneau R, Barke R, Santilli S.M and Roy S. Hypoxia differentially regulates arterial and venous smooth muscle cell proliferation via PDGFRβ and VEGFR-2 expression. Am JPhysiol Heart Circ Physiol ajpheart.00411.2011; published ahead of print December 9, 2011, doi:10.1152/ajpheart.00411.2011 PMID: 22159994 PMCID: 3311452

Chanakira A, Dutta R, Charboneau R, Barke R, Santilli S.M and Roy S. Differential Migration of Arterial vs. Venous Derived Smooth Muscle Cells under Hypoxia and Hypoxia Induced Endothelial Growth Factors. AHA: ATVB Abstract April 2011Oral presentation: Vascular Initiatives (ATVB) April 2011 Chicago: Differential Migration of Arterial vs. Venous Derived Smooth Muscle Cells under Hypoxia and Hypoxia Induced Endothelial Growth Factors

Chanakira A, Kir D, Barke RA, Santilli SM, Ramakrishnan S, Roy S. (2015)Hypoxia Differentially Regulates Arterial and Venous Smooth Muscle Cell Migration. PLoS One. 2015 Sep 18;10(9):e0138587. doi: 10.1371/journal.pone.0138587. eCollection 2015. PMID: 26381529 PMCID: PMC 4575051

Chanakira A, Westmark PR, Ong IM, Sheehan JP. (2017) Tissue factor-factor VIIa complex triggers protease activatedreceptor 2-dependent growth factor release and migration in ovarian cancer. Gynecol Oncol. 2017 Apr;145(1):167-175. doi: 10.1016/j.ygyno.2017.01.022. Epub 2017 Jan 29. PMID: 28148395  PMCID: PMC5359044

Hall, Aric C.
Mentor: Ryan Mattison
Years in RTH T32 Programs:2014 -2015

Hall AC, Kahl B. Splenic Lymphomas Presenting as Splenomegaly. Oncology (Williston Park). 2015 Jun 15;29(6). pii: 211867 PMID: 26091676 [PubMed - in process]

(Bobeck) Kraayenbrink, Elizabeth
Mentor: Gumperz, Jenny E.
Years in RTH T32 Programs:2015 -2016

Hess NJ, S Bharadwaj N, Bobeck EA, McDougal CE, Ma S, Sauer JD, Hudson AW, Gumperz JE. iNKT cells coordinate immune pathways to enable engraftment in nonconditioned hosts.Life Sci Alliance. 2021 Jun 10;4(7):e202000999. doi: 10.26508/lsa.202000999. Print 2021 Jul.PMID: 34112724 

Drennan, Amanda
Mentor: Li Xin Rui
Years in RTH T32 Programs:2013 -2016

Drennan A, Kraemer M, Capp M, Gries T, Ruff E, Sheppard C, Wigneshweraraj S, Artsimovitch I, Record MT Jr. Key roles of the downstream mobile jaw of Escherichia coli RNA polymerase in transcription initiation. Biochemistry. 2012 Nov 27;51(47):9447-59. doi: 10.1021/bi301260u. Epub 2012 Nov 14.PMID:23116321 

Ruff EF, Drennan AC, Capp MW, Poulos MA, Artsimovitch I, Record MT Jr. E. coli RNA Polymerase Determinants of Open Complex Lifetime and Structure. J Mol Biol. 2015 Jul 31;427(15):2435-50. doi: 10.1016/j.jmb.2015.05.024. Epub 2015 Jun 6. PMID: 26055538 PMCID:PMC4520765

Zheng M, Turton KB, Zhu F, Li Y, Grindle KM, Annis DS, Lu L, Drennan AC, Tweardy DJ, Bharadwaj U, Mosher DF, Rui L. A mix of S and ΔS variants of STAT3 enable survival of activated B-cell-like diffuse large B-cell lymphoma cells in culture. Oncogenesis. 2016 Jan 4;4:e184. doi: 10.1038/oncsis.2015.44. PMID: 26727576 PMCID: PMC4728674

Rui L, Drennan AC, Ceribelli M, Zhu F, Wright GW, Huang DW, Xiao W, Li Y, Grindle KM, Lu L, Hodson DJ, Shaffer AL, Zhao H, Xu W, Yang Y, Staudt LM. Epigenetic gene regulation by Janus kinase 1 in diffuse large B-cell lymphoma Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):E7260-E7267. doi: 10.1073/pnas.1610970113. Epub 2016 Oct 31.PMID: 27799566 PMCID: PMC5135360

Lu L, Zhu F, Zhang M, Li Y, Drennan AC, Kimpara S, Rumball I, Selzer C, Cameron H, Kellicut A, Kelm A, Wang F, Waldmann TA, Rui L. Gene regulation and suppression of type I interferon signaling by STAT3 in diffuse large B cell lymphoma Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E498-E505. doi: 10.1073/pnas.1715118115. Epub 2018 Jan 2.PMID: 29295936 PMCID: PMC5776985

Drennan AC, Krishna S, Seeger MA, Andreas MP, Gardner JM, Sether EKR, Jaspersen SL, Rayment I. Structure and function of Spc42 coiled-coils in yeast centrosome assembly and duplication Mol Biol Cell. 2019 Jun 1;30(12):1505-1522. doi: 10.1091/mbc.E19-03-0167. Epub 2019 Apr 10.PMID: 30969903 PMCID:PMC6724696

Hind, Laurel
Mentor: Huttenlocher, Anna
Years in RTH T32 Programs:2015 -2016

Hind LE, Mackay JL, Cox D, Hammer DA. Two-dimensional motility of a macrophage cell line on microcontact-printed fibronectin. Cytoskeleton (Hoboken). 2014 Sep;71(9):542-54. doi: 10.1002/cm.21191. Epub 2014 Oct 3 PMID: 25186818

Hind LE, Dembo M, Hammer DA. Macrophage motility is driven by frontal-towing with a force magnitude dependent on substrate stiffness. Integr Biol (Camb). 2015 Apr;7(4):447-53. doi: 10.1039/c4ib00260a. PMID: 25768202

Yamahashi Y, Cavnar PJ, Hind LE, Berthier E, Bennin DA, Beebe D, Huttenlocher A. Integrin associated proteins differentially regulate neutrophil polarity and directed migration in 2D and 3D. Biomed Microdevices. 2015 Oct;17(5):100. doi: 10.1007/s10544-015-9998-x. PMID: 26354879

Hind LE, Vincent WJ, Huttenlocher A. Leading from the Back: The Role of the Uropod in Neutrophil Polarization and Migration. Dev Cell. 2016 Jul 25;38(2):161-9. doi: 10.1016/j.devcel.2016.06.031. Review. PMID: 27459068 PMCID: PMC4982870

Hind LE, Lurier EB, Dembo M, Spiller KL, Hammer DA. Effect of M1-M2 Polarization on the Motility and Traction Stresses of Primary Human Macrophages, Cell Mol Bioeng. 2016 Sep;9(3):455-465. doi: 10.1007/s12195-016-0435-x. Epub 2016 Apr 18.PMID: 28458726 PMCID:PMC5404741

Powell D, Tauzin S, Hind LE, Deng Q, Beebe DJ, Huttenlocher A. Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues, Cell Rep. 2017 May 23;19(8):1572-1585. doi: 10.1016/j.celrep.2017.04.078.PMID: 28538177 PMCID:PMC5505660

Ingram PN, Hind LE, Jiminez-Torres JA, Huttenlocher A, Beebe DJ. An Accessible Organotypic Microvessel Model Using iPSC-Derived Endothelium, Adv Healthc Mater. 2018 Jan;7(2):10.1002/adhm.201700497. doi: 10.1002/adhm.201700497. Epub 2017 Aug 7.PMID: 29364596 PMCID: PMC6402823

Hind LE, Ingram PN, Beebe DJ, Huttenlocher A. Interaction with an endothelial lumen increases neutrophil lifetime and motility in response to P aeruginosa, Blood. 2018 Oct 25;132(17):1818-1828. doi: 10.1182/blood-2018-05-848465. Epub 2018 Aug 24.PMID: 30143504 PMCID: PMC6202912


Hind LE, Huttenlocher A. Neutrophil Reverse Migration and a Chemokinetic Resolution, Dev Cell. 2018 Nov 19;47(4):404-405. doi: 10.1016/j.devcel.2018.11.004.PMID: 30458135

Giese MA, Hind LE, Huttenlocher A. Neutrophil plasticity in the tumor microenvironment Blood. 2019 May 16;133(20):2159-2167. doi: 10.1182/blood-2018-11-844548. Epub 2019 Mar 21.PMID: 30898857 PMCID: PMC6524564

McMinn PH, Hind LE, Huttenlocher A, Beebe DJ. Neutrophil trafficking on-a-chip: an in vitro, organotypic model for investigating neutrophil priming, extravasation, and migration with spatiotemporal control, Lab Chip. 2019 Nov 7;19(21):3697-3705. doi: 10.1039/c9lc00562e. Epub 2019 Oct 2.PMID: 31576879 PMCID: PMC7045365

Yu J, Piazza A, Sparks S, Hind LE, Niles DJ, Ingram PN, Huang W, Ricke WA, Jarrard DF, Huttenlocher A, Basu H, Beebe DJ. A reconfigurable microscale assay enables insights into cancer-associated fibroblast modulation of immune cell recruitment, Integr Biol (Camb). 2021 Apr 20;13(4):87-97. doi: 10.1093/intbio/zyab004.PMID: 33822934

Hind LE, Giese MA, Schoen TJ, Beebe DJ, Keller N, Huttenlocher A. Immune Cell Paracrine Signaling Drives the Neutrophil Response to A. fumigatus in an Infection-on-a-Chip Model, Cell Mol Bioeng. 2020 Oct 13;14(2):133-145. doi: 10.1007/s12195-020-00655-8. eCollection 2021 Apr.PMID: 33868496 PMCID: PMC8010091

Richardson IM, Calo CJ, Hind LE. Microphysiological Systems for Studying Cellular Crosstalk During the Neutrophil Response to Infection,  Front Immunol. 2021 Apr 27;12:661537. doi: 10.3389/fimmu.2021.661537. eCollection 2021.PMID: 33986752 PMCID: PMC8111168

Klemm LC, Denu RA, Hind LE, Rocha-Gregg BL, Burkard ME, Huttenlocher A. Centriole and Golgi microtubule nucleation are dispensable for the migration of human neutrophil-like cells, Mol Biol Cell. 2021 Aug 15;32(17):1545-1556. doi: 10.1091/mbc.E21-02-0060. Epub 2021 Jun 30.PMID: 34191538 

Ingram, Patrick
Mentor: Beebe, David
Years in RTH T32 Programs:2015 - 2016

Chen YC, Cheng YH, Kim HS, Ingram PN, Nor JE, Yoon E. Paired single cell co-culture microenvironments isolated by two-phase flow with continuous nutrient renewal. Lab Chip. 2014 Aug 21;14(16):2941-7. doi: 10.1039/c4lc00391h. PMID: 24903648

Chung J, Ingram PN, Bersano-Begey T, Yoon E. Traceable clonal culture and chemodrug assay of heterogeneous prostate carcinoma PC3 cells in microfluidic single cell array chips. Biomicrofluidics. 2014 Nov 14;8(6):064103. doi: 10.1063/1.4900823. eCollection 2014 Nov. PMID: 25553180

Chen YC, Allen SG, Ingram PN, Buckanovich R, Merajver SD, Yoon E. Single-cell Migration Chip for Chemotaxis-based Microfluidic Selection of Heterogeneous Cell Populations. Sci Rep. 2015 May 18;5:9980. doi: 10.1038/srep09980. PMID: 25984707

Choi YJ, Ingram PN, Yang K, Coffman L, Iyengar M, Bai S, Thomas DG, Yoon E, Buckanovich RJ. Identifying an ovarian cancer cell hierarchy regulated by bone morphogenetic protein 2. Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E6882-8. doi: 10.1073/pnas.1507899112. Epub 2015 Nov 30. PMID: 26621735

Chen YC, Ingram PN, Fouladdel S, McDermott SP, Azizi E, Wicha MS, Yoon E. High-Throughput Single-Cell Derived Sphere Formation for Cancer Stem-Like Cell Identification and Analysis. Sci Rep. 2016 Jun 13; 6:27301. doi: 10.1038/srep27301. PMID: 27292795

Chen YC, Zhang Z, Fouladdel S, Deol Y, Ingram PN, McDermott SP, Azizi E, Wicha MS, Yoon E Single cell dual adherent-suspension co-culture micro-environment for studying tumor-stromal interactions with functionally selected cancer stem-like cells.. Lab Chip. 2016 Aug 7;16(15):2935-45. doi: 10.1039/c6lc00062b. Epub 2016 Jul 6. PMID: 27381658

Chen YC, Baac HW, Lee KT, Fouladdel S, Teichert K, Ok JG, Cheng YH, Ingram PN, Hart AJ, Azizi E, Guo LJ, Wicha MS, Yoon E. Selective Photomechanical Detachment and Retrieval of Divided Sister Cells from Enclosed Microfluidics for Downstream Analyses,  ACS Nano. 2017 May 23;11(5):4660-4668. doi: 10.1021/acsnano.7b00413. Epub 2017 May 8.PMID: 28480715

Ingram PN, Hind LE, Jiminez-Torres JA, Huttenlocher A, Beebe DJ. An Accessible Organotypic Microvessel Model Using iPSC-Derived Endothelium, Adv Healthc Mater. 2018 Jan;7(2):10.1002/adhm.201700497. doi: 10.1002/adhm.201700497. Epub 2017 Aug 7.PMID: 29364596 PMCID: PMC6402823

Hind LE, Ingram PN, Beebe DJ, Huttenlocher A. Interaction with an endothelial lumen increases neutrophil lifetime and motility in response to P aeruginosa, Blood. 2018 Oct 25;132(17):1818-1828. doi: 10.1182/blood-2018-05-848465. Epub 2018 Aug 24.PMID: 30143504 PMCID: PMC6202912

Yu J, Piazza A, Sparks S, Hind LE, Niles DJ, Ingram PN, Huang W, Ricke WA, Jarrard DF, Huttenlocher A, Basu H, Beebe DJ. A reconfigurable microscale assay enables insights into cancer-associated fibroblast modulation of immune cell recruitment, Integr Biol (Camb). 2021 Apr 20;13(4):87-97. doi: 10.1093/intbio/zyab004.PMID: 33822934

Jin, Ning
Mentor: Mattison, Ryan
Years in RTH T32 Programs: 2016 - 2017

Jin NBurkard ME. MACROD2, an Original Cause of CIN? Cancer Discov. 2018 Aug;8(8):921-923. doi: 10.1158/2159-8290.CD-18-0674.PMID: 30076143 Comment

Jin N, Lera RF, Yan RE, Guo F, Oxendine K, Horner VL, Hu Y, Wan J, Mattison RJ, Weaver BA, Burkard ME. Chromosomal instability upregulates interferon in acute myeloid leukemia, Genes Chromosomes Cancer. 2020 Nov;59(11):627-638. doi: 10.1002/gcc.22880. Epub 2020 Jul 18.PMID: 32557940 PMCID: PMC7597364

Hu Y, Manasrah BK, McGregor SM, Lera RF, Norman RX, Tucker JB, Scribano CM, Yan RE, Humayun M, Wisinski KB, Tevaarwerk AJ, O'Regan RM, Wilke LG, Weaver BA, Beebe DJ, Jin NBurkard ME. Paclitaxel Induces Micronucleation and Activates Pro-Inflammatory cGAS-STING Signaling in Triple-Negative Breast Cancer Mol Cancer Ther. 2021 Sep 28. doi: 10.1158/1535-7163.MCT-21-0195. Online ahead of print.PMID: 34583980 PMCID: PMC


Esbona K, Jin N, Correia-Staudt K, Lager A, Laffin J, Weaver B, Burkard M. Chromosomal instability predicts taxane sensitivity in breast cancer. San Antonio Breast Cancer Symposium, Dec 8th 2017, San Antonio, TX

Jin N. Burkard M, 2018, Chromosome instability as a prognostic factor & an immunotheraputic target in Acute Myeloid Leukemia, AACR Annual Meeting Chicago, IL, April 14-18 2018.

Soukup, Alexandra
Mentor: Bresnick, Emery
Years in RTH T32 Programs: 2016 - 2019

Soukup AA, Keller NP, Wiemann P. Enhancing Nonribosomal Peptide Biosynthesis in Filamentous Fungi. Methods Mol Biol. 2016;1401:149-60. doi: 10.1007/978-1-4939-3375-4_10. PMID: 26831707

Henke MT, Soukup AA, Goering AW, McClure RA, Thomson RJ, Keller NP, Kelleher NL. New Aspercryptins, Lipopeptide Natural Products, Revealed by HDAC Inhibition in Aspergillus nidulans. ACS Chem Biol. 2016 Aug 19;11(8):2117-23. doi: 10.1021/acschembio.6b00398. Epub 2016 Jun 24. PMID: 27310134

Soukup AA, Fischer GJ, Luo J, Keller NP. The Aspergillus nidulans Pbhp1 homolog is required for normal sexual development and secondary metabolism. Fungal Genet Biol. 2017 Mar:100:13-21. doi: 10.1016/j.fgb.2017.01.004. Epub 2017 Jan9. PMID: 28089630 PMCID: PMC5337145

Pfannenstiel BT. Zhao X, Wortman J, Wiemann P, Throckmorton K, Spaker JE, Soukup AA, Luo X, Linder DL, Lim FY, Knox BP, Haas B, Fischer GJ, Choera T,  Butchko RAE, Bok JW, Affeldt KJ, Keller NP, Palmer JM. Revitalization of a froward genetic screen identifies three new regulators of fungal secondary metabolism in the genus aspergillus. MBio. 2017 Sep 5;8(5). pii: e01246-17. doi: 10.1128/mBio.01246-17 PMID: 28874473 PMCID:PMC5587912.

Wiemann P, Soukup AA, Folz JS, Wang PM, Noack A, Keller NP. CoIN: co-inducible nitrate expression system for secondary metabolites in aspergillus nidulans. Fungal Biol Biotechnol. 2018 Mar 13;5:6 doi: 10.1186/s40694-018-0049-2 eCollection 2018 PMID: 29564145  PMCID: PMC5851313

Lind AL, Lim FY, Soukup AA, Keller NP, Rokas A. An LaeA- and BrlA-Dependent cellularnetwork governs tissue-specificsecondary metabolism in the human pathogen aspergillus fumigatu. mSphere 2018 Mar 14:3(2). pii.e00050-18. doi: 10.1128/mSphere.00050-18 eCollection 2018 Mar-APR. PMID: 29564395 PMCID: PMC5853485

Katsumura KR, Mehta C, Hewitt KJ, Soukup AA, Fraga de Andrade I, Ranheim EA, Johnson KD, Bresnick EH. Human leukemia mutations corrupt but do not abrogate GATA-2 function. Proc Natl Acad Sci U S A. 2018 Oct23;115(43):E10118. doi:10.1073/pnas. 1813015115 Epub2018 Oct 9 PMID: 30301799  PMCID: PMC6205465

Soukup AA, Zheng Y, Mehta C, Wu J, Cao M, Hofmann I, Zhou Y, Zhang J, Johnson KD, chi K, Keles S, Bresnick EH. Single-nucleotie human disease mutation inactivates a blood-regenerative GATA2 enhancer. J Clin Invest. 2019 Mar 1;129(3): 1180-1192. doi: 10.1172/JCI122694. Epub 2019 Feb 11 PMID: 30620726 PMCID: PMC6391105.

Soukup AA, Bresnick EH. GATA2 +9.5 enhancer: from principles of hematopoiesis to genetic diagnosis in precision medicineCurr Opin Hematol. 2020 May;27(3):163-171. doi: 10.1097/MOH.0000000000000576.PMID: 32205587, PMCID: PMC7331797

Liu P, Soukup AA, Bresnick EH, Dewey CN, Keleş S. PRAM: a novel pooling approach for discovering intergenic transcripts from large-scale RNA sequencing experiments.Genome Res. 2020 Nov;30(11):1655-1666. doi: 10.1101/gr.252445.119. Epub 2020 Sep 21.PMID: 32958497 PMCID: PMC7605252

You X, Zhou Y, Chang YI, Kong G, Ranheim EA, Johnson KD, Soukup AA, Bresnick EH, Zhang J. Gata2 +9.5 enhancer regulates adult hematopoietic stem cell self-renewal and T cell development.Blood Adv. 2021 Sep 13:bloodadvances.2021004311. doi: 10.1182/bloodadvances.2021004311. Online ahead of print.PMID: 34516632

Wiesner, Darin
Mentor: Klein, Bruce
Years in RTH T32 Programs: 2017 - 2019

Wiesner DL, Klein BS., 2017, The balance between immunity and inflammation. Science. 2017 Sep 8;357(6355):973-974. doi: 10.1126/science. aao3086. No abstract available. PMID: 28883060

Wiesner DL, Klein BS., (2017), Lung epithelium: barrier immunity to inhaled fungi and driver of fungal-associated allergic asthma. Curr Opin Microbiol. 2017 Oct 26; 40:8-13. doi: 10.1016/j.mib.2017.10.007. [Epub ahead of print] Review. PMID: 29096195

Hernandez-Santos N, Wiesner DL, Fites JS, McDermott AJ, Warner T, Wuthrich M, Klein BS. Lung Epithelial cells coordinate innate lymphocytesand immunity against pulmonary fungal infection. Cell Host Microbe.  2018 Apr 11;23(4):511-522.e5. doi10.1016/j.chom.2018.02.011 Epub 20188 Mar22 PMID: 29576482 PMCID: PMC5951304

Sui P, Wiesner DL, XU J, Zhang Y, Lee J, Van Dyken S, Lasua A, Yu C, Klein BS, Lockley RM, Deutsch G, Sun X. Pulmonary Neuroendocrine cell amplify allergic asmtha responses. Science 2018 jun 8: 360(6393). pii:eaan8546 doi:10.1126/science. aan8546. Epub 2018 Mar 29. PMID29599193 PMCID: PMC6387886

Mukaremera L, Lee KK, Wagener J, Wiesner DL, Gow NAR, Nielsen K. Titan cell producton in Cryptococcus nepformans reshapes the cell wall and the capsule composition during infection. Cell Surf 2018 Mar, 1: 15-24. doi: 10.1016/j.tcsw.2017.12.001 Epub 2018 Feb 16, PMID 30123851 PMCID: PMC6095662

DeAngelo, Christopher
Mentor: Callander, Natalie
Years in RTH T32 Programs: 2018 - 2020

D'Angelo CR, Sudakaran S, Callander NS. Clinical effects and applications of the gut microbiome in hematologic malignancies.Cancer. 2021 Mar 1;127(5):679-687. doi: 10.1002/cncr.33400. Epub 2020 Dec 28.PMID: 33369893

Evens AM, Danilov A, Jagadeesh D, Sperling A, Kim SH, Vaca R, Wei C, Rector D, Sundaram S, Reddy N, Lin Y, Farooq U, D'Angelo C, Bond DA, Berg S, Churnetski MC, Godara A, Khan N, Choi YK, Yazdy M, Rabinovich E, Varma G, Karmali R, Mian A, Savani M, Burkart M, Martin P, Ren A, Chauhan A, Diefenbach C, Straker-Edwards A, Klein AK, Blum KA, Boughan KM, Smith SE, Haverkos BM, Orellana-Noia VM, Kenkre VP, Zayac A, Ramdial J, Maliske SM, Epperla N, Venugopal P, Feldman TA, Smith SD, Stadnik A, David KA, Naik S, Lossos IS, Lunning MA, Caimi P, Kamdar M, Palmisiano N, Bachanova V, Portell CA, Phillips T, Olszewski AJ, Alderuccio Burkitt lymphoma in the modern era: real-world outcomes and prognostication across 30 US cancer centers. JP.Blood. 2021 Jan 21;137(3):374-386. doi: 10.1182/blood.2020006926.PMID: 32663292

Hess, Nicholas 
Mentor: Gumperz, Jenny
Years in RTH T32 Programs: 2016 -2020

Hess NJ, Hudson AW, Hematti P, Gumperz JE. Early T Cell Activation Metrics Predict Graft-versus-Host Disease in a Humanized Mouse Model of Hematopoietic Stem Cell Transplantation.J Immunol. 2020 Jul 1;205(1):272-281. doi: 10.4049/jimmunol.2000054. Epub 2020 May 22.PMID: 32444392 PMCID: PMC7329317

Hess NJ, Lindner PN, Vazquez J, Grindel S, Hudson AW, Stanic AK, Ikeda A, Hematti P, Gumperz JE. Different Human Immune Lineage Compositions Are Generated in Non-Conditioned NBSGW Mice Depending on HSPC Source.Front Immunol. 2020 Oct 19;11:573406. doi: 10.3389/fimmu.2020.573406. eCollection 2020.PMID: 33193358 PMCID: PMC7604455

Hess NJ, S Bharadwaj N, Bobeck EA, McDougal CE, Ma S, Sauer JD, Hudson AW, Gumperz JE. iNKT cells coordinate immune pathways to enable engraftment in nonconditioned hosts.Life Sci Alliance. 2021 Jun 10;4(7):e202000999. doi: 10.26508/lsa.202000999. Print 2021 Jul.PMID: 34112724 

Houseright, Ruth
Mentor: Huttenlocher, Anna
Years in RTH T32 Programs: 2017 - 2020

de Oliveira S, Houseright RA, Graves AL, Golenberg N, Korte BG, Miskolci V, Huttenlocher A. Metformin modultes innate immune-mediated inflammation and early progression of NAFLD-associated heptocellular carcinoma in zebrafish. J Hepatol. 2018 Dec 18. pii.S0168-8278(18)32622-9. doi: 10.1016/j.jhep 2018.11.034. PMID: 30572006 PMCID: PMC6436385

de Oliveira S, Houseright RA, Korte BG, Huttenlocher A. DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of fibrolamellar carcinoma.Dis Model Mech. 2020 Apr 30;13(4):dmm042564. doi: 10.1242/dmm.042564.PMID: 32102783 PMCID: PMC7197716

Houseright RA, Rosowski EE, Lam PY, Tauzin SJM, Mulvaney O, Dewey CN, Huttenlocher A. Cell type specific gene expression profiling reveals a role for complement component C3 in neutrophil responses to tissue damage.Sci Rep. 2020 Sep 24;10(1):15716. doi: 10.1038/s41598-020-72750-9.PMID: 32973200 PMCID: PMC7518243

 Houseright RA, Miskolci V, Mulvaney O, Bortnov V, Mosher DF, Rindy J, Bennin DA, Huttenlocher A.J Myeloid-derived growth factor regulates neutrophil motility in interstitial tissue damage. Cell Biol. 2021 Aug 2;220(8):e202103054. doi: 10.1083/jcb.202103054. Epub 2021 May 28.PMID: 34047769

Matson, Daniel
Mentor: Bresnick Emery
Years in RTH T32 Programs: 2019-2020

Castaño J, Aranda S, Bueno C, Calero-Nieto FJ, Mejia-Ramirez E, Mosquera JL, Blanco E, Wang X, Prieto C, Zabaleta L, Mereu E, Rovira M, Jiménez-Delgado S, Matson DR, Heyn H, Bresnick EH, Göttgens B, Di Croce L, Menendez P, Raya A, Giorgetti A. GATA2 Promotes Hematopoietic Development and Represses Cardiac Differentiation of Human Mesoderm. Stem Cell Reports. 2019 Sep 10;13(3):515-529. doi: 10.1016/j.stemcr.2019.07.009. Epub 2019 Aug 8.PMID: 31402335

Ray S, Chee L, Matson DR, Palermo NY, Bresnick EH, Hewitt KJ. Sterile α-motif domain requirement for cellular signaling and survival.J Biol Chem. 2020 May 15;295(20):7113-7125. doi: 10.1074/jbc.RA119.011895. Epub 2020 Apr 2.PMID: 32241909 

Smeenk L, Ottema S, Mulet-Lazaro R, Ebert A, Havermans M, Varea AA, Fellner M, Pastoors D, van Herk S, Erpelinck-Verschueren C, Grob T, Hoogenboezem RM, Kavelaars FG, Matson DRBresnick EH, Bindels EM, Kentsis A, Zuber J, Delwel R. Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia.Cancer Discov. 2021 May 12. doi: 10.1158/2159-8290.CD-20-1793. Online ahead of print.PMID: 33980539

Mehta C, Fraga de Andrade I, Matson DR, Dewey CN, Bresnick EH. RNA-regulatory exosome complex confers cellular survival to promote erythropoiesis.Nucleic Acids Res. 2021 Sep 20;49(16):9007-9025. doi: 10.1093/nar/gkab367.PMID: 34059908

Rocha-Gregg, Briana
Mentor: Huttenlocher, Anna
Years in RTH T32 Programs: 2019 - 2021

Rocha-Gregg BL, Huttenlocher A. Swarming motility in host defense.Science. 2021 Jun 18;372(6548):1262-1263. doi: 10.1126/science.abj3065.PMID: 34140369

Klemm LC, Denu RA, Hind LE, Rocha-Gregg BL, Burkard ME, Huttenlocher A. Centriole and Golgi microtubule nucleation are dispensable for the migration of human neutrophil-like cells.Mol Biol Cell. 2021 Aug 15;32(17):1545-1556. doi: 10.1091/mbc.E21-02-0060. Epub 2021 Jun 30.PMID: 34191538 PMCID: PMC8351748​​​​​​

Rocha-Gregg B, Huttenlocher A. Signal integration in forward and reverse neutrophil migration: Fundamentals and emerging mechanisms.Curr Opin Cell Biol. 2021 Oct;72:124-130. doi: 10.1016/ Epub 2021 Aug 16.PMID: 34411839