University of Wisconsin-Madison
Kirschstein National Research Service Award
(NIH National Heart, Lung, and Blood Institute Grant: T32 HL07899)
Areas of Emphasis:
Our grant emphasizes pre-doctoral and post-doctoral training in the areas of vascular biology, and hematopoetic stem cells and malignancy. Vascular biology is critically important for human disease, impacting on basic processes such as inflammation, the immune response, hemostasis, thrombosis, and metastasis. We have assembled a broad array of expertise in cellular and molecular aspects of hemostasis, extracellular matrix biology, vasculogenesis/angiogenesis, cellular mechanisms of inflammation, the genetics of diabetes, lipoprotein metabolism, and clinical aspects if hemophilic and thrombophilic states. Likewise, hematopoetic stem cells are important to therapeutic approaches in a variety of disease states, and the University of Wisconsin is an internationally recognized leader in embryonic stem cell biology. The participating investigators have expertise in the biology and hematopoetic differentiation of embryonic stem cells, chromatin modifications in hematopoiesis and leukemogenesis, intracellular signaling in myeloma, clinical trials in lymphoma, bone marrow transplantation, and clinical applications of embryonic stem cells in vascular and malignant disease. There is a strong emphasis on providing the multidisciplinary training required to pursue translational research opportunities, and the formal training of clinical investigators. Our training program takes advantage of the Clinical Investigator Preparatory Program (K30 grant) at the University of Wisconsin to provide didactic training in clinical trial design and biostatistics for candidates pursuing translational research projects.