Figure 4. Homology model of zebrafish factor VII. The three-dimensional structure of zebrafish factor VIIa (Right) was generated by homology modeling (see Materials and Methods) compared with the crystal structure of human factor VIIa (Left) from the soluble tissue factor-factor VIIa complex. rms agreement of the alpha carbon backbone of zebrafish with human factor VIIa is color-coded (blue < 2 Å, yellow = 2-4 Å, red > 4 Å). Sheehan et al PNAS 98(15): 8768-8773.