University of Wisconsin
School of Medicine and Public Health

Dr Sheehan's Selected Publications

Sheehan, J.P., Wu, Q.Y., Tollefsen, D.M., and Sadler, J.E. (1993). Mutagenesis of Thrombin Selectively Modulates Inhibition by Serpins Heparin Cofactor II and Antithrombin III: Interaction with the Anion-Binding Exosite Determines Heparin Cofactor II Specificity. J. Biol. Chem. 268:3639-3645 (Abstract)

Sheehan, J.P. and Sadler, J.E. (1994) Molecular Mapping of the Heparin Binding Exosite of Thrombin. Pro. Natl. Acad. Sci. USA 91:5518-5522 (Abstract)

Sheehan, J.P., Tollefsen, D.M. and Sadler, J.E. (1994) Heparin Cofactor II is Regulated Allosterically and Not Primarily by Template Effects: Studies with Mutant Thrombins and Glycosaminoglycans. J. Biol. Chem. 269:32747-32751(Abstract)

Sheehan, J.P. and Lan, H.C. (1998) Phosphorothioate Oligonucleotides Inhibit the Intrinsic Tenase Complex. Blood 92:1617-1625 (Abstract)

Jagadeeswaran, P., Liu, Y.C., and Sheehan, J.P. (1998) Analysis of Hemostasis in the Zebrafish. Methods Cell. Biol. 59:337-358 (Abstract)

Jagadeeswaran, P. and Sheehan, J.P. (1999) Analysis of Blood Coagulation in the Zebrafish. Blood Cells, Molecules, and Diseases 25:239-249 (Abstract)

Jagadeeswaran, P., Sheehan, J.P., Craig, F., and Troyer, D. (1999) Identification and Characterization of Zebrafish Thrombocytes. Br J Haematol. 107(4):731-738) (Abstract)

Sheehan, J.P. and Phan, T. (2001) Phosphorothioate Oligonucleotides Inhibit the Intrinsic Tenase Complex by an Allosteric Mechanism. Biochemistry 40(16): 4980-4989 (Abstract)

Sheehan, J.P., Templer, M., Gregory, M., Hanumanthaiah, R., Troyer, D., Phan, T.M., Thankavel, B., and Jagadeeswaran, P. (2001) Demonstration of the Extrinsic Coagulation Pathway in Teleosti: Identification of Zebrafish Coagulation Factor VII. Pro. Natl. Acad. Sci. USA 98:8768-8773 (Abstract)

Sheehan, J.P., Kobbervig, C.E., and Kirkpatrick, H.M. (2003) Heparin Inhibits the Intrinsic Tenase Complex by Interacting with an Exosite on Factor IXa. Biochemistry 42(38): 11316-11325 (Abstract)

Yuan, Q.P., Walke, E.N., and Sheehan, J.P. (2005) The Factor IXa Heparin-Binding Exosite is a Cofactor Interactive Site: Mechanism for antithrombin-independent inhibition of intrinsic tenase by heparin. Biochemistry 44(9): 3615-3625 (Abstract)

Sheehan, J.P. and Walke, E.N. (2006) Depolymerized Holothurian Glycosaminoglycan and Heparin Inhibit the Intrinsic Tenase Complex by a Common Antithrombin-Independent Mechanism. Blood 107(10):3876-82. PMCID: PMC1895295 (Abstract)

Misenheimer, T.M., Buyue, Y., and Sheehan, J.P. (2007) The Heparin-binding Exosite is Critical to Allosteric Activation of Factor IXa in the Intrinsic Tenase Complex: The role of arginine 165 and factor X. Biochemistry 46(26):7886-95. PMCID: PMC2569175 (Abstract)

Buyue, Y., Whinna, H., Sheehan, J.P. (2008) The Heparin-Binding Exosite of Factor IXa is a Critical Regulator of Plasma Thrombin Generation and Venous Thrombosis. Blood, 112(8): 3234-3241. [Epub Jul 22, 2008]. PMCID: PMC2569175 (Abstract)

Buyue, Y., and Sheehan, J.P. (2009) Fucosylated Chondroitin Sulfate Inhibits Plasma Thrombin Generation via Targeting of the Factor IXa Heparin-Binding Exosite. Blood 114 (14) 3092-100 [Epub May 4, 2009]. PMCID: PMC2756211 (Abstract)

Misenheimer, T.M. and Sheehan, J.P. (2010) The Regulation of Factor IXa by Super-sulfated Low Molecular Weight Heparin. Biochemistry 49(46):9997-100005 [Epub Oct. 27, 2010] PMID: 20945941 (Abstract)

Matafonov A, Sarilla S, Sun MF, Sheehan JP, Serebrov V, Verhamme IM, Gailani D. (2011) Activation of factor XI by products of prothrombin activation. Blood. 2011 Jul 14;118(2):437-45. Epub 2011 Apr 28 (Abstract)

Buyue, Y., and Sheehan, J.P. (2012) Low molecular Weight Heparin Inhibits Thrombin Generation via Direct Targeting of Factor IXa: Contribution of the serpin-independent in human plasma. Journal of Thrombosis and Haemostasis Oct;10(10):2086-98 PMCID:  PMC3463736 (Abstract)

Buyue, Y., Misenheimer, T.M., and Sheehan, J.P. (2013) Low Molecular Weight Heparin Inhibits Thrombin Generation via Direct Targeting of Factor IXa: A Reply to Rebuttal.  Journal of Thrombosis and Haemostasis Mar;11(3):565-6. PMID: 23332108 (Abstract)

Geng, Y., Verhamme, I.M., Smith, S.A., Cheng, Q., Sun, M., Sheehan, J.P., Morrissey, J.H.,  and Gailani, D. (2013) Factor XI Anion-Binding Sites are required for Productive Interactions with Polyphosphate. Journal of Thrombosis and Haemostasis Nov;11(11):2020-8.  PMID: 24118982 (Abstract)