University of Wisconsin
School of Medicine and Public Health

Dr Sheehan's Selected Publications

Sheehan, J.P., Wu, Q.Y., Tollefsen, D.M., and Sadler, J.E. (1993). Mutagenesis of Thrombin Selectively Modulates Inhibition by Serpins Heparin Cofactor II and Antithrombin III: Interaction with the Anion-Binding Exosite Determines Heparin Cofactor II Specificity. J. Biol. Chem. 268:3639-3645 (Abstract)

Sheehan, J.P. and Sadler, J.E. (1994) Molecular Mapping of the Heparin Binding Exosite of Thrombin. Pro. Natl. Acad. Sci. USA 91:5518-5522 (Abstract)

Sheehan, J.P., Tollefsen, D.M. and Sadler, J.E. (1994) Heparin Cofactor II is Regulated Allosterically and Not Primarily by Template Effects: Studies with Mutant Thrombins and Glycosaminoglycans. J. Biol. Chem. 269:32747-32751(Abstract)

Sheehan, J.P. and Lan, H.C. (1998) Phosphorothioate Oligonucleotides Inhibit the Intrinsic Tenase Complex. Blood 92:1617-1625 (Abstract)

Jagadeeswaran, P., Liu, Y.C., and Sheehan, J.P. (1998) Analysis of Hemostasis in the Zebrafish. Methods Cell. Biol. 59:337-358 (Abstract)

Jagadeeswaran, P. and Sheehan, J.P. (1999) Analysis of Blood Coagulation in the Zebrafish. Blood Cells, Molecules, and Diseases 25:239-249 (Abstract)

Jagadeeswaran, P., Sheehan, J.P., Craig, F., and Troyer, D. (1999) Identification and Characterization of Zebrafish Thrombocytes. Br J Haematol. 107(4):731-738) (Abstract)

Sheehan, J.P. and Phan, T. (2001) Phosphorothioate Oligonucleotides Inhibit the Intrinsic Tenase Complex by an Allosteric Mechanism. Biochemistry 40(16): 4980-4989 (Abstract)

Sheehan, J.P., Templer, M., Gregory, M., Hanumanthaiah, R., Troyer, D., Phan, T.M., Thankavel, B., and Jagadeeswaran, P. (2001) Demonstration of the Extrinsic Coagulation Pathway in Teleosti: Identification of Zebrafish Coagulation Factor VII. Pro. Natl. Acad. Sci. USA 98:8768-8773 (Abstract)

Sheehan, J.P., Kobbervig, C.E., and Kirkpatrick, H.M. (2003) Heparin Inhibits the Intrinsic Tenase Complex by Interacting with an Exosite on Factor IXa. Biochemistry 42(38): 11316-11325 (Abstract)

Yuan, Q.P., Walke, E.N., and Sheehan, J.P. (2005) The Factor IXa Heparin-Binding Exosite is a Cofactor Interactive Site: Mechanism for antithrombin-independent inhibition of intrinsic tenase by heparin. Biochemistry 44(9): 3615-3625 (Abstract)

Sheehan, J.P. and Walke, E.N. (2006) Depolymerized Holothurian Glycosaminoglycan and Heparin Inhibit the Intrinsic Tenase Complex by a Common Antithrombin-Independent Mechanism. Blood 107(10):3876-82. PMCID: PMC1895295 (Abstract)

Misenheimer, T.M., Buyue, Y., and Sheehan, J.P. (2007) The Heparin-binding Exosite is Critical to Allosteric Activation of Factor IXa in the Intrinsic Tenase Complex: The role of arginine 165 and factor X. Biochemistry 46(26):7886-95. PMCID: PMC2569175 (Abstract)

Buyue, Y., Whinna, H., Sheehan, J.P. (2008) The Heparin-Binding Exosite of Factor IXa is a Critical Regulator of Plasma Thrombin Generation and Venous Thrombosis. Blood, 112(8): 3234-3241. [Epub Jul 22, 2008]. PMCID: PMC2569175 (Abstract)

Buyue, Y., and Sheehan, J.P. (2009) Fucosylated Chondroitin Sulfate Inhibits Plasma Thrombin Generation via Targeting of the Factor IXa Heparin-Binding Exosite. Blood 114 (14) 3092-100 [Epub May 4, 2009]. PMCID: PMC2756211 (Abstract)

Misenheimer, T.M. and Sheehan, J.P. (2010) The Regulation of Factor IXa by Super-sulfated Low Molecular Weight Heparin. Biochemistry 49(46):9997-100005 [Epub Oct. 27, 2010] PMID: 20945941 (Abstract)

Matafonov A, Sarilla S, Sun MF, Sheehan JP, Serebrov V, Verhamme IM, Gailani D. (2011) Activation of factor XI by products of prothrombin activation. Blood. 2011 Jul 14;118(2):437-45. Epub 2011 Apr 28 (Abstract)

Buyue, Y., and Sheehan, J.P. (2012) Low molecular Weight Heparin Inhibits Thrombin Generation via Direct Targeting of Factor IXa: Contribution of the serpin-independent in human plasma. Journal of Thrombosis and Haemostasis Oct;10(10):2086-98 PMCID:  PMC3463736 (Abstract)

Buyue, Y., Misenheimer, T.M., and Sheehan, J.P. (2013) Low Molecular Weight Heparin Inhibits Thrombin Generation via Direct Targeting of Factor IXa: A Reply to Rebuttal.  Journal of Thrombosis and Haemostasis Mar;11(3):565-6. PMID: 23332108 (Abstract)

Geng, Y., Verhamme, I.M., Smith, S.A., Cheng, Q., Sun, M., Sheehan, J.P., Morrissey, J.H.,  and Gailani, D. (2013) Factor XI Anion-Binding Sites are required for Productive Interactions with Polyphosphate. Journal of Thrombosis and Haemostasis Nov;11(11):2020-8.  PMID: 24118982 (Abstract)

Westmark PR, Tanratana P, Sheehan JP. Selective disruption of heparin and antithrombin-mediated regulation of human factor IX J Thromb Haemost. 2015 Jun;13(6):1053-63. doi: 10.1111/jth.12960. Epub 2015 May 10.PMID: 25851619

Nazeef M, Sheehan JP. New developments in the management of moderate-to-severe hemophilia B J Blood Med. 2016 Apr 1;7:27-38. doi: 10.2147/JBM.S81520. eCollection 2016.PMID: 27099538

Chanakira A, Westmark PR, Ong IM, Sheehan JP. Tissue factor-factor VIIa complex triggers protease activated receptor 2-dependent growth factor release and migration in ovarian cancer Gynecol Oncol. 2017 Apr;145(1):167-175. doi: 10.1016/j.ygyno.2017.01.022. Epub 2017 Jan 29.PMID: 28148395

Sheehan JP. Zebrafish factor 10 and the life aquatic Blood. 2017 Aug 3;130(5):563-565. doi: 10.1182/blood-2017-06-789149.PMID: 28775159

Tanratana P, Ellery P, Westmark P, Mast AE, Sheehan JP. Elevated Plasma Factor IXa Activity in Premenopausal Women on Hormonal Contraception Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):266-274. doi: 10.1161/ATVBAHA.117.309919. Epub 2017 Nov 2.PMID: 29097362 

Plautz WE, Sekhar Pilli VS, Cooley BC, Chattopadhyay R, Westmark PR, Getz T, Paul D, Bergmeier W, Sheehan JP, Majumder R.Arterioscler  Anticoagulant Protein S Targets the Factor IXa Heparin-Binding Exosite to Prevent Thrombosis Thromb Vasc Biol. 2018 Apr;38(4):816-828. doi: 10.1161/ATVBAHA.117.310588. Epub 2018 Feb 1.PMID: 29419409

Garnett ER, Lomax JE, Mohammed BM, Gailani D, Sheehan JP, Raines RT. Phenotype of ribonuclease 1 deficiency in mice RNA. 2019 Aug;25(8):921-934. doi: 10.1261/rna.070433.119. Epub 2019 May 3.PMID: 31053653

Sheehan JP. Mapping the zymogen to protease transition in FIXa J Thromb Haemost. 2021 Jun;19(6):1409-1411. doi: 10.1111/jth.15286.PMID: 34047009