An endocrine tumor is a mass affecting any organ in the endocrine system. In some cases, endocrine tumors are a source of hormone production. Endocrine-related cancers include cancers of the breast, prostate, pituitary, testes, ovary and neuroendocrine system as well as hormone-dependent cancers in other parts of the body.
Learn More About Endocrine-related Cancer Research
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Molecular origins of endocrine-related cancer & obesity
Clinical studies to test novel therapeutic agents for endocrine-related cancers
Molecular Biology Research on Endocrine Tumors
Researchers in the laboratory of Vincent Cryns, MD focus on the pathogenesis of endocrine-related cancers, especially breast cancer, and translating these insights into improved biomarkers and therapies. A key discovery of the Cryns laboratory has been that a protein named aβ-crystallin promotes the survival and metastasis of an aggressive form of breast cancer. These “triple negative” tumors lack expression of estrogen receptor, progesterone receptor and HER2, rendering them difficult to treat. aβ-crystallin is being investigated as a potential drug target.
Clinical Research on Endocrine Tumors & Neuroendocrine Tumors
The Endocrine Tumor Disease Oriented Working Group is a multidisciplinary team of clinical researchers who conduct clinical studies to test novel therapeutic agents for endocrine-related cancers such as medullary thyroid cancer, carcinoid, other neuroendocrine tumors and thyroid cancer. Part of the UW Carbone Cancer Center Experimental Therapeutics translational research effort, this team is headed by Dr. Herb Chen, Chief of Endocrine Surgery and includes faculty members from the divisions of Endocrinology and Hematology, Medical Oncology and Palliative Care in the Department of Medicine and the Departments of Pathology and Radiology.