Therapeutic Targets for Diabetes

Michelle E. Kimple, PhD, leads a translational research team composed of trainees at all levels. The research focus of the Kimple Lab is understanding how the insulin-producing beta-cells of the pancreas respond to nutrients and hormones to function, multiply, and survive. Understanding the mechanisms behind these processes, and how they are affected in the pathophysiological conditions of type 1 and type 2 diabetes, is a critically important area of research.

Dr. Michelle Kimple in her lab

Understanding the Pathways of Diabetes Pathogenesis

Dr. Kimple's research team is especially interested in elucidating how dysfunctional G protein-coupled receptor signaling pathways contribute to the pathogenesis of type 1 and type 2 diabetes.

The long-term goal of the Kimple Lab is to translate these insights into new and improved diabetes therapeutics, preventing or even curing these life-long diseases.

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Above, research in the Kimple Lab has revealed a critical role of the the Gz-coupled EP3 receptor, which is activated by prostaglandin E2 (PGE2), in blocking the ability of the pancreatic beta-cell to secrete insulin into the bloodstream to control blood sugar levels.

When activated by PGE2, the Gz-coupled receptor also limits the ability of the beta-cell to replicate and survive in the face of the multiple insults its exposed to in the conditions of type 1 and type 2 diabetes.

Research Team

Graduate Student

Research Specialist

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Rodsy Modhumira

Graduate Student

Administrative Specialist

Undergraduate Students

  • Amelia Bader
  • Katelyn Glory
  • Krupa Patel
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Join Us!

There are many opportunities for motivated individuals in the Kimple Lab! We are currently seeking undergraduate students, graduate students and a research specialist/technician interested in working in a vibrant basic science laboratory environment.

If you are interested in joining the group, please send your CV or resume and a brief description of your research experience. For undergraduates without previous experience in a research lab, please describe the skills you acquired in any laboratory courses you have taken.

Funding Support

Dr. Kimple's research is funded by the Department of Veterans Affairs, Juvenile Diabetes Research Association, and Department of Defense.

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Help Us Transform Medicine

You can help support research by making a gift to the Department of Medicine's Excellence in Endocrinology, Diabetes and Metabolism Fund.