Dr. Lee Eckhardt is a clinical cardiac electrophysiologist who joined the Department of Medicine in the Division of Cardiovascular Medicine as an Associate Professor in 2007. She obtained her Medical Degree from Georgetown University School of Medicine in Washington, DC and stayed to complete her training in Internal Medicine at the Georgetown University Medical Center. She trained at the University of Wisconsin for her Cardiovascular Medicine fellowship. She received her sub-specialty training in Clinical Cardiac Electrophysiology at the Brigham and Women's Hospital in Boston, Massachusetts. Dr. Eckhardt is Board Certified in Internal Medicine (ABIM), Cardiovascular Diseases (ABIM), and Clinical Cardiac Electrophysiology.
Dr. Eckhardt practices clinical cardiac electrophysiology and is co-director of the Inherited Arrhythmias Clinic. Her research interests are related to the cellular mechanisms of inherited arrhythmia syndromes and cellular electrophysiology. She is a member of the Cardiovascular Research Center (CVRC) and her research efforts are in conjunction with the Cellular and Molecular Arrhythmia Research Program.
Eckhardt, LL, Alberte, C. Catheter Ablation for D-TGA Related Atrial FlutterUsing Intracardiac Guided Echocardiography. J of Innovations in Cardiac Rhythm Management, 2010 Oct; 1(2).
Medeiros-Domingo A, Tan BH, Crotti L, Tester DJ, Eckhardt L, Cuoretti A, Kroboth SL, Song C, Zhou Q, Kopp D, Schwartz PJ, Makielski JC, Ackerman MJ. "Gain-of-Function Mutation, S422L, in the KCNJ8-Encoded Cardiac KATP Channel Kir6.1 as a Pathogenic Substrate for J Wave Syndromes" Heart Rhythm. 2010 Oct;7(10):1466-71.
Eckhardt LL, Teelin TC, January CT. Is Ranolazine and Antiarrhythmic Drug? American Journal of Physiology Heart Circ Physiology. March 2008.
Eckhardt LL, Farley AL, Rodriguez E, Ruwaldt K, Hammill D, Tester DJ, Ackerman MJ, Makielski JC. KCNJ2 mutations in arrhythmia patients referred for LQT testing: A mutation T305A with novel effect on rectification properties. Heart Rhythm. 2007 Mar; 4(3):323-9.
Sridharan Rajamani, PhD*, Lee L. Eckhardt, MD*, Carmen R. Valdivia, PhD, Christine A. Klemens, BS, Brad M. Gillman, MS, Corey L. Anderson, BS, Katherine M. Holzem, BA, Brian P. Delisle, PhD, Blake D. Anson, PhD, Jonathan C. Makielski, MD, Craig T. January, MD, PhD. Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine. Br J Pharmacol. 2006 Nov; 149(5):481-9.
Sridharan Rajamani, Corey L. Anderson, Carmen R. Valdivia, Lee L. Eckhardt, Jason D. Foell, Gail A. Robertson, Timothy J. Kamp, Jonathan C. Makielski, Blake D. Anson and Craig T. January. "Specific Serine Proteases Selectively Damage KCNH2 (hERG1) Potassium Channels and IKr." Am J Physiol Heart Circ Physiol, 290(3):H1278-88, Mar 2006.
Lee L. Eckhardt, Sridharan Rajamani, and Craig T. January. Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome. Br J Pharmacol. 2005 May;145(1):3-4.