B-cell Lymphoma Research 

Lixin Rui, PhD, is a National Institutes of Health-funded investigator in basic and translational lymphoma research.

His research uses multi-omics approaches and animal models to identify potential molecular targets in cell signaling pathways for development of new therapeutic strategies.

Portrait of Dr. Lixin Rui

Discovering Molecular Targets in B-cell Receptor Pathways

The major research focus of Dr. Rui’s laboratory is the molecular mechanisms of B-cell receptor and JAK-STAT signaling pathways and epigenetic enzymes, including protein arginine methyltransferase 5 (PRMT5) and DNA methyltransferases (DNMTs), in lymphomagenesis.

His research team employs a multidisciplinary approach, using biochemistry, RNA interference, genomic technologies (e.g., ChIP-seq, RNA-seq and single-cell RNA-seq), CRISPR/Cas9 and systems biology methods, to identify mechanisms downstream of the B-cell receptor and JAK-STAT signaling pathways and establish the function of these epigenetic enzymes in B cell lymphoma.

The goal of his research is to discover molecular targets in these pathways for therapeutic, diagnostic and prognostic development of B-cell lymphoma.

Research Team

Sophie Petta

Undergraduate Student

photo of Dr. Lixin Rui's hand pointing at heatmap charts on a computer screen
Join Us!

There are opportunities for motivated individuals in the Rui Lab! We are currently seeking undergraduates, graduate students and postdocs interested in cell signaling and cancer genomic/epigenetic research in B-cell lymphoma.

If you are interested in joining the group, please send your CV and a brief description of your research experience and interests to Dr. Rui.

Active Projects

  • EGR1-mediated drug resistance in diffuse large B cell lymphoma
  • Role of DNMT3A and DNMT3B in mantle cell lymphoma 
  • PRMT5 in activation of the PI3K signaling pathway

Funding Support

Dr. Rui’s research is funded by the National Institutes of Health/National Cancer Institute.

closeup of a male scientist in white lab coat working in the lab

Help Us Transform Medicine

You can help support research by making a gift to the Department of Medicine's Excellence in Hematology/Oncology Fund.