University of Wisconsin
School of Medicine and Public Health

Characterizing the time course of Alzheimer’s disease and Related Disorders

Dr Tobey Betthauser

Understanding the utility of fluid and imaging biomarkers for AD detection and progression

The lab of Tobey Betthauser, PhD, focuses on understanding the sequence of events that occur in neurodegenerative diseases with a focus on Alzheimer’s disease. In Alzheimer’s disease, characteristic pathologic lesion form one to two decades prior to the onset of cognitive symptoms, during a phase referred to as “preclinical AD.” Dr. Betthauser’s current work includes developing and evaluating novel approaches to characterizing the time course of amyloid accumulation and other pathophysiologic processes in AD using biomarkers for these biological targets.

The lab is also undertaking studies to investigate the sensitivity and specificity of in vivo biomarkers for their molecular targets with postmortem confirmation of pathologic entities. This combined research is designed to better the understanding of the clinical and research utility and limitations of fluid and imaging biomarkers to detect pathophysiologic processes during life, and to better understand how these pathologic processes influence symptoms of disease.

Active Research Projects:

  • Longitudinal biomarker modeling
  • Neuropathological validation of in vivo biomarker

Dr. Betthauser Faculty Profile