Director, Nuclear Cardiology
Director, Cardiovascular Medicine Outreach Program
Charles Stone received his undergraduate and graduate education at Colgate University and Cornell University Medical College. He completed his residency in internal medicine at the University of Michigan and his cardiology fellowship at Strong Memorial Hospital at the University of Rochester. Stone joined the faculty at the University of Wisconsin in 1988 as director of Nuclear Cardiology. In addition to his general cardiology responsibilities on the inpatient service and the Cardiovascular Medicine outpatient clinic, he is director of the Nuclear Cardiology Section and the Exercise Stress Laboratory.
His clinical activities include supervising and interpreting treadmill and pharmacologic stress tests, interpreting cardiac perfusion studies, angiocardiograms and PET scans, implementing novel imaging protocols, and serving as clinical liaison for the Nuclear Cardiology Section. The Nuclear Cardiology Section provides a broad base of nuclear imaging techniques, including a variety of perfusion scintigraphic protocols, radionuclide angiocardiograms and positron emission tomography.
Stone's research interests focus on studies of myocardial metabolism and perfusion using PET and gamma camera agents. The perfusion studies have involved generator-produced 62Cu tracers, metabolic studies concerning glucose and fatty acid analogs and studies of oxygen levels in the heart using hypoxic markers. Studies have used isolated organ preparations, extra-corporally perfused open-chest preparations, closed-chest catheterized animals and clinical studies.
His research awards include the National Research Service Award and the American Heart Association Wisconsin Affiliate David McClain Award.
Search for Charles Stone's literature abstracts on PubMed
Stone CK, Pooley RA, DeGrado TR, Renstrom B, Nickles RJ, Nellis SH, Liedtke AJ, Holden JE: Myocardial uptake of the fatty acid analog 14-18F-fluoro-6-thia-heptadecanoic acid (FTHA) in comparison to beta-oxidation rates by tritiated palmitate. J Nucl Med 1998; 39:1690-1696.
Renstrom B, Rommelfanger S, Stone CK, DeGrado TR, Carlson KJ, Scarbrough E, Nickles RJ, Liedtke AJ, Holden JE: Comparison of the retention of fatty acid tracers FTHA and BMIPP during myocardial ischemia and hypoxia. J Nucl Med 1998; 39:1684-1690.
Wallhaus TR, Lacy J, Whang J, Green MA, Nickles RJ, Stone CK. Human biodistribution and dosimetry of the PET perfusion agent copper-62-PTSM. J Nucl Med 1998; 39(11):1958-1964.
Hochachka PW, Clark CM, Matheson GO, Brown WD , Stone CK, Nickles RJ, Holden JE: Effects on regional brain metabolism of high-altitude hypoxia: A study of six US marines. Am J Physiol 1999; 277(Regulatory Integrative Comp Physiol 46): R314-319.
Taylor M, Wallhaus TR, DeGrado TR, Russell DC, Stanko P, Nickles RJ, Stone CK: Evaluation of myocardial fatty acid and glucose uptake using positron emission tomography with [18F]fluoro-6-thia-heptadecanoic acid (FTHA) and 18F-fluoro-2-deoxyglucose (FDG) in patients with congestive heart failure. J Nucl Med 42:55-62, 2001.
Wallhaus Thomas R., Taylor, Michael, Degrado, Tomothy R., Russell, Douglas C., Stanko, Peter, Nickles, Robert J., Stone, Charles K. Myocardial free fatty acid and glucose utilization following carvedilol treatment in patients with congestive heart failure. Circulation. 103:2441-2446, 2001.
Taylor M, Wallhaus TR, DeGrado TR, Russell DC, Stanko P, Nickles RJ, Stone CK: Evaluation of myocardial fatty acid and glucose uptake using positron emission tomography with 18F-fluoro-6-thia-heptadecanoic acid (FTHA) and 18F-fluoro-2-deoxyglucose (FDG) in patients with congestive heart failure. J Nucl Med 42:55-62, 2001.