University of Wisconsin
School of Medicine and Public Health

Matthew Wolff, MD



MADISON, WI 53792-0001

(608) 263-0836

Dr. Matthew Wolff graduated from the Johns Hopkins University School of Medicine and received his internal medicine training at Johns Hopkins Hospital. From 1988-1989 he served as an assistant chief of service in the Department of Medicine at Hopkins, then remained to complete both cardiology and interventional cardiology fellowships. He joined the faculty at the University of Wisconsin Medical School in 1993 and in July of 1999 became the Director of the Adult Cardiac Catheterization Laboratory. In 2005 he served as Chief of the Division of Cardiovascular Medicine and remained on faculty until 2011, when he became Associate Medical Director for Cardiovascular Medicine and Surgery at the Unity Point Health - Meriter-Heart and Vascular Institute and Medical Director, Cardiovascular Services at Unity Point Health-Meriter Heart Hospital. In 2018, he was appointed as a clinical adjunct faculty member in the Department of Medicine upon the establishment of a business relationship between UW Health and UnityPoint Health-Meriter that closely links the state’s largest academic medical center with a highly respected community hospital.

In addition to his clinical activities as an interventional cardiologist, Wolff maintained both clinical and basic cardiovascular research programs. He has been the principal investigator in a number of multicenter trials in interventional cardiology. His research interests include interventional cardiology, cardiac gene transfer and therapeutic angiogenesis and has resulted in more than 40 original, peer-reviewed publications in major cardiovascular journals. He is a former recipient of a National Institutes of Health Clinical Investigator Development Award, and served as chair of the Small Business Special Emphasis Panel of the National Heart, Lung and Blood Institute from 2009 to 2011.

Dr. Wolff served as the Governor of the Wisconsin Chapter of the American College of Cardiology from 2007-2011 and served during this timeframe on the ACCs National Interventional Council and the ACC Innovations in Intervention program committee. He was a co-chair of the ACCs 2006 Annual National Scientific Sessions.

Dr. Wolff maintains an active inpatient and outpatient clinical practice specializing in ischemic heart disease.

Search for Matthew Wolff's literature abstracts on PubMed


Wolff MR, McDonald KS, Moss RL. Rate of tension development in cardiac muscle varies with level of activator calcium. Circ Res 1995; 76:154-160.

Wolff MR, Whitesell LF, Moss RL. Calcium sensitivity of isometric tension is increased in experimental heart failure. Circ Res 1995; 76:781-789.

Wolff MR, Buck SH, Stoker SW, Greaser ML, Mentzer RM. Myofibrillar calcium sensitivity of isometric tension is increased in human dilated cardiomyopathies: Role of altered beta-adrenergically mediated protein phosphorylation. J Clin Invest 1996; 98:167-176.

McDonald KS, Wolff MR, Moss RL. Force-velocity and power-load curves in rat skinned cardiac myocytes. J Physiol 1998; 511:519-531.

Fatkin D, MacRae C, Sasaki T, Wolff MR, Porcu M, Frenneaux M, Atherton J, Vidaillet HJ, Spudich S, De Girolami U, Seidman JG, Seidman CE. Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease. New Engl J Med 1999; 341:1715-1724.