University of Wisconsin
School of Medicine and Public Health

Puglielli Lab identifies a potential target for Alzheimer’s therapy

Luigi Puglielli, MD, PhD

Luigi Puglielli, MD, PhD, professor, Geriatrics and Gerontology, and his lab published a study in Communications Biology on the roles of two enzymes that are imperative to protein production, which could lead to potential treatments for age-related diseases, like Alzheimer’s disease.

Using mouse models, the team found that targeting the enzyme, Atase1, as opposed to Atase2, can help prevent Alzheimer’s disease.

This finding can contribute to new therapies that are impacted by this enzyme and aid in drug discovery to treat age-related diseases.

Read the full article from the Waisman Center.