University of Wisconsin
School of Medicine and Public Health

Merrins Research

Matthew J. Merrins, PhD | Pancreatic islet biology

Matthew Merrins, PhD, is a federally funded investigator whose research focuses on metabolic signaling in the pancreatic islets of Langerhans. As metabolic sensors for an organism, islets regulate blood glucose by releasing the hormones insulin and glucagon.

Dr. Matthew Merrins' faculty biography

Research Overview

Dr. Merrins' lab is interested in two features of nutrient metabolism in islet cells: the ability to trigger pulses of insulin release, and the ability to fine-tune hormone secretion through cell-cell communication.

To understand how these processes adapt to environmental stress, his team uses mouse models of obesity/diabetes in combination with biochemistry, patch clamp electrophysiology, and quantitative imaging. By using fluorescence microscopy (3D light-sheet imaging, optogenetics, and 2-photon microscopy), they can monitor biochemical reactions as they occur in living cells.

Image
Visualizing pancreatic islet metabolism with 2-photon NAD(P)H fluorescence lifetime imaging

Above, visualizing pancreatic islet metabolism with 2-photon NAD(P)H fluorescence lifetime imaging

Merrins lab website