University of Wisconsin
School of Medicine and Public Health

Jarjour Lab Research

Jarjour Research

Severe Asthma Research Program (SARP, U10 HL 1091680)

The SARP research group is one of the largest NIH studies currently being conducted, in several cities throughout the U.S. The purpose of this study is to better classify asthma types to develop treatments unique to each asthma type.

Role of Eosinophils in Airway Inflammation and Remodeling (P01 HL088594)

Airway eosinophilia is an important marker of asthma severity, risk of exacerbation, and response to therapy. Our program project grant focuses on how eosinophils contribute to asthma pathophysiology by enhancing airway inflammation and remodeling.

Jarjour ResearchProject 1 investigates key eosinophil (EOS) functions including promoting IL-17 responses and enhancing fibroblast (Fb) function via expression of semaphorin 7A (SEMA7A), which leads to promoting myoFb differentiation and generation of extracellular matrix (ECM) components.

PI: Nizar N. Jarjour, MD

Project 2 investigates how the matrix protein periostin interacts with eosinophils through the integrin αMß2 to enhance their survival, mediator release, and response to eosinophil-active cytokines.

PI: Deane Mosher, MD

Project 3 investigates how Pin1 influences Smad6 and Smad3 signaling to regulate signaling of the profibrotic cytokine TGF-β1 in eosinophils and fibroblasts.

PI: James S. Malter, MD

Clinical Core PI: Loren Denlinger, MD

Laboratory Core PI: Sameer Mathur, MD

Administrative Core Lead: Gina Crisafi