The SARP research group is one of the largest NIH studies currently being conducted, in several cities throughout the U.S. The purpose of this study is to better classify asthma types to develop treatments unique to each asthma type.
Airway eosinophilia is an important marker of asthma severity, risk of exacerbation, and response to therapy. Our program project grant focuses on how eosinophils contribute to asthma pathophysiology by enhancing airway inflammation and remodeling.
Project 1 investigates key eosinophil (EOS) functions including promoting IL-17 responses and enhancing fibroblast (Fb) function via expression of semaphorin 7A (SEMA7A), which leads to promoting myoFb differentiation and generation of extracellular matrix (ECM) components.
Project 2 investigates how the matrix protein periostin interacts with eosinophils through the integrin αMß2 to enhance their survival, mediator release, and response to eosinophil-active cytokines.
PI: Deane Mosher, MD
Project 3 investigates how Pin1 influences Smad6 and Smad3 signaling to regulate signaling of the profibrotic cytokine TGF-β1 in eosinophils and fibroblasts.
Administrative Core Lead: Gina Crisafi