Dr. Denlinger is board-certified in Pulmonary and Critical Care Medicine. He serves as the Assitant Director for Research for the Division of Allergy, Pulmonary and Critical Care and as Research Oversignt Director for the Pulmonary and Critical Care Fellowship. Dr. Denlinger is a trainer on several Institutional NIH Training Grants. Research areas of interest include severe asthma, bronchiectasis, Mycobacterial diseases, and lung infections.
The Denlinger lab studies the roles of extracellular nucleotides as paracrine stress hormones. One specific project centers on a nucleotide receptor P2X7 and its role in amplifying innate immune responses to infectious and allergic stimuli recognized by Toll Like Receptors. The Denlinger lab is interested in the regulation of expression and function of the human P2RX7 gene as well as its contribution to airway disorders. P2X7 is a nonselective cation channel expressed by leukocytes and epithelial cells that is involved in amplification of innate immune cytokine responses and microbial killing. An active project focuses on the post-transcriptional control mechanisms of P2RX7 expression in human bronchial epithelial cells. We also have a functional screening assay that has proven reliable in identifying subjects with variant alleles. Using this assay as an epidemiological tool in collaboration with several investigators at the UW Asthma Center, we are testing the hypothesis that attenuated P2X7 function contributes to increased asthma symptoms and/or biomarkers driven by respiratory viruses and atypical bacteria.
Denlinger Lab Research Areas