1685 HIGHLAND AVE
MADISON, WI 53705-2281
MD, PhD - Medical Scientist Training Program
University of Chicago, Pritzker School of Medicine
PhD, Department of Pathology
- 1991 - 1995
BS with Honors, Major: Biochemistry and Molecular Biology
University of Wisconsin - Madison
Internal Medicine-Research/Categorical Pathway
University of Washington - Seattle, WA
Endocrinology, Diabetes and Metabolism Fellowship - Research Pathway
University of Wisconsin - Madison
- Internal Medicine, 2006
Endocrinology, Diabetes, and Metabolism, 2008
- Associate Professor
University of Wisconsin School of Medicine and Public Health
Director of Research – Endocrine Division
Department of Medicine , Division of Endocrinology, Diabetes, and Metabolism
- Section Chief, Endocrinology
William S Middleton VA Hospital, Madison, WI Staff Physician
- Co-Director, Integrated Program in Endocrinology (iPEND)
Integrated program in endocrinology, reproductive endocrinology, diabetes and metabolism – bringing together PhD training program, research collaborations, research seminars, core resource development across multiple departments. University of Wisconsin – Madison
- Chair-Elect, Midwest Region
National Council Member
American Federation for Medical Research
- Editorial Board – Journal of Investigative Medicine, Endocrine Today
Honors and Awards
- 2015 Puestow Research Award – University of Wisconsin Department of Medicine – junior member of faculty who has made significant research contribution to medicine
- 2014 American Federation for Medical Research Junior Physician Investigator Award
- 2013 UW Health Patient Experience Physician Champion Award
- 2013 American Federation for Medical Research Scholar Award
- 2010 Excellence in Endocrine Teaching Award
- 2008 Dickie Research Award – University of Wisconsin – Department of Medicine; for significant research contributions made toward advancing the field of medicine during fellowship
Dr. Davis sees patients through UW Hospital and Clinics and at the William S. Middleton Memorial Veterans Hospital. She has a broad clinical practice, with a special interest in diabetes, hypoglycemic disorders, genetic disorders in endocrinology and diabetes, adrenal disorders, pituitary disease, and obesity.
Dr. Davis runs a federally funded research lab focused on pancreatic beta cell biology. One area of focus is on understanding the mechanisms underlying the growth response in the beta cell. Beta cells normally do not grow, but can be stimulated to divide and expand in response to certain stimuli. When faced with insulin resistance and increased demand for insulin during pregnancy or in the setting of obesity, the beta cell will divide and overall beta cell mass is increased. Conversely, one of the defects in type 2 diabetes is a loss of overall beta cell mass leading to insufficient insulin production. In addition, type 1 diabetes is caused by autoimmune destruction of the beta cell, although there is evidence that a small population of beta cells may continue to attempt to replicate and expand in the setting of ongoing autoimmune attack. Understanding the mechanisms of beta cell proliferation that occur naturally in these adaptive settings may help us identify new therapeutic targets that can help drive beta cell proliferation in the patient with prediabetes, type 2 diabetes, a recent islet transplant, or potentially even type 1 diabetes in combination with immune therapies.
A second area of interest is in beta cell death, or apoptosis. Numerous stressors lead to increased beta cell apoptosis in early type 1 diabetes and in type 2 diabetes. We are also studying the ways that the pancreatic islet adapts to stressors and promotes beta cell survival.
Understanding the mechanisms of beta cell growth and survival that occur naturally in these adaptive settings may help us identify new therapeutic targets that can help drive beta cell proliferation in the patient with prediabetes, type 2 diabetes, a recent islet transplant, or potentially even type 1 diabetes in combination with immune therapies.
Dr. Davis also conducts clinical research in collaboration with a number of other investigators. She has led a study to understand the mechanisms of hypoglycemia in gastric bypass surgery patients and to test a novel treatment for this disorder. She has ongoing collaborative studies looking at biomarkers for diabetes, novel dietary interventions for weight loss and diabetes prevention, and the treatment of diabetes in hospitalized patients.
Lab website: http://www.medicine.wisc.edu/endocrinology/davislab
Search for Dawn Davis' literature abstracts on PubMed