Contact Information

Photo of Karen Hansen
Karen Hansen, MD, MS

ASSOCIATE PROFESSOR

RHEUMATOLOGY

UW MED FNDTN CENTENNIAL BLDG
1685 HIGHLAND AVE
MADISON, WI 53705-2281

(608) 263-3457





Biography

Dr. Karen Hansen is a tenured Associate Professor of Medicine and Board-Certified Rheumatologist employed by the University of Wisconsin. Her primary research focus centers around issues related to osteoporosis, including risk factors, diagnosis and management of osteoporosis. She has published several studies on factors that influence calcium absorption. Her latest NIH-sponsored study is a randomized, double-blind trial to compare the effects of placebo, low-dose and high-dose vitamin D therapy on changes in calcium absorption, bone density and muscle fitness in 230 postmenopausal women with serum 25(OH)D levels between 15 and 25 ng/mL at study entry.

PUBLICATIONS

  1. Hansen KE, Jefferson J: Lithium and Arthritis, A Review. Lithium 1992;3:1-5. Policy Exempt – published prior to April 2008
  2. Hansen KE, Kirkpatrick S, Laxova R: Dubowitz Syndrome: long-term follow-up of an original patient. Am J Med Gen 1995;55:161-164. Policy Exempt – published prior to April 2008
  3. Hansen KE: Antiphospholipid Antibodies: a review of associated conditions, diagnosis, and treatment. Resident Reporter 1998;3:9-14. Policy Exempt – published prior to April 2008
  4. Hansen KE, Arnason J, Bridges A: Autoantibodies and common viral illnesses. Semin Arthritis Rheum 1998;27:263-271. Policy Exempt – published prior to April 2008
  5. Hansen KE, St Clair EW: Disseminated histoplasmosis in systemic lupus erythematosus: case report and review of the literature. Semin Arthritis Rheum 1998;28:193-199. Policy Exempt – published prior to April 2008
  6. Hansen KE, Moore KD, Ortel TL, Allen NB: Antiphospholipid antibodies in patients with Wegener’s granulomatosis and polyarteritis nodosa. Arthritis Rheum 1999;42:2250-2252. Policy Exempt – published prior to April 2008
  7. Hansen KE, Kong D, Moore KD, Ortel TL: Risk factors associated with thrombosis in patients with antiphospholipid antibodies. J Rheumatol 2001 Sept;28(9):2018-24. Policy Exempt – published prior to April 2008
  8. Hansen KE, Cush J, Singhal A, Cooley DA, Cohen S, Patel SR, Genovese M, Sundaramurthy S, Schiff M: The safety and efficacy of leflunomide in combination with infliximab in rheumatoid arthritis. Arthritis Rheum 2004;51(2):228-232. Policy Exempt – published prior to April 2008
  9. Kramm H, Hansen KE, Gowing E, Bridges AJ: Successful therapy of rheumatoid arthritis with rituximab: renewed interest in the role of B cells in the pathogenesis of rheumatoid arthritis. J Clin Rheumatol 2004;10(1):28-32. Policy Exempt – published prior to April 2008
  10. Hansen KE, Hildebrand JP, Genovese M, Cush JJ, Patel S, Cooley DA, Cohen SA, Gagnon RE, Schiff M: The efficacy of switching from etanercept to infliximab in subjects with rheumatoid arthritis. J Rheumatol 2004;31(6):1098-1102. Policy Exempt – published prior to April 2008
  11. Binkley N, Krueger D, Cowgill CS, Plum L, Lake E, Hansen KE, DeLuca HF, Drezner MK: Assay variation confounds the diagnosis of hypovitaminosis D: a call for standardization. J Clin Endocrinol Metab 2004;89(7):3152-57. Policy Exempt – published prior to April 2008
  12. Hansen KE, Vallarta-Ast N, Krueger D, Gangnon R, Drezner MK, Binkley N. Use of the lowest vertebral body to diagnose lumbar osteoporosis in men: Is “cherry picking” appropriate? J Clin Densitom 2004;7(4):376-381. Policy Exempt – published prior to April 2008
  13. Hansen KE, Binkley N, Christian R, Vallarta-Ast N, Krueger D, Drezner MK, Blank RB. Interobserver Reproducibility of Criteria for Vertebral Body Exclusion. J Bone Miner Res 2005;20(3):501-508. Policy Exempt – published prior to April 2008
  14. Hansen KE, Hildebrand JP, Ferguson EE, Stein JH: Outcomes in 45 Patients with Statin-Associated Myopathy. Arch Intern Med 2005;165(22):2671-2676. Policy Exempt – published prior to April 2008
  15. Khurma V, Appen R, Wolf MD, Hansen KE: Wegener Granulomatosis Presenting as Bilateral Loss of Vision. J Clin Rheumatol 2005;11(5):267-269. Policy Exempt – published prior to April 2008
  16. Christian R, Hansen KE: Transplant Osteoporosis. Curr Opin Orthop 2005;16:382-386. Policy Exempt – published prior to April 2008
  17. Blank RD, Malone DG, Christian RC, Vallarta-Ast N, Krueger D, Drezner MK, Binkley N, Hansen KE: Patient Variables Impact Lumbar Spine Dual Energy X Ray Absorptiometry Precision. Osteoporosis Int 2006;17(5):768-774. Policy Exempt – published prior to April 2008
  18. Hansen KE, Ferguson EE, Stein JH: Reply to commentaries on “Outcomes in 45 Patients with Statin Associated Myopathy.” Arch Intern Med 2006;166:1233. Policy Exempt – published prior to April 2008
  19. Hansen KE, Hoffman RM, Drake RK, Argal TR, Bier HA, Grigg KT, Rouse ED, Elliot ME: An Exploratory Analysis of Alendronate in Older Men with Low Creatinine Clearance. Journal of Aging & Pharmacotherapy 2006;13(2)21-33. Policy Exempt – published prior to April 2008
  20. Hansen KE, Rosenblatt ER, Gjerde CL, Crowe MC: Can an Online Osteoporosis Lecture Increase Physician Knowledge and Improve Patient Care? J Clin Densitom 2007;10(1):10-20. Policy Exempt – published prior to April 2008
  21. Wolff AE, Hansen KE, Zakowski L: Acute Kawasaki’s Disease: Not Just for Kids. J Gen Intern Med 2007;22(5)681-684. Policy Exempt – published prior to April 2008.
  22. Hansen KE, Binkley N, Blank RD, Krueger DC, Malone DG, Christian RC, Baim S: An Atlas Improves Interobserver Agreement Regarding Application of the ISCD Vertebral Body Exclusion Criteria. J Clin Densitom 2007;10(4):359-364. Policy Exempt – accepted for publication prior to April 2008
  23. Hansen KE, Binkley N, Blank RD, Krueger DC, Irene Golembiewski, Baim S: An Atlas of Focal Structural Anomalies: Case Series, released in September 2007 by the International Society for Clinical Densitometry at http://www.iscd.org/fsa.Policy Exempt – published prior to April 2008
  24. Hansen KE, Swenson ED, Baltz B, Schuna AA, Jones AN, Elliot ME: Adherence to alendronate in male veterans. Osteoporosis Int 2008;19:349. Policy Exempt – published prior to April 2008
  25. Hansen KE, Jones AN, Lindstrom MJ, Davis LA, Engelke JA, Shafer MM, Vitamin D Insufficiency: Disease or No Disease? J Bone Miner Res 2008;23(7):1052-1060. NIHMSID 51882, PMC2574556
  26. Wolff AE, Jones AN, Hansen KE: Vitamin D and musculoskeletal health. Nat Clin Pract Rheumatol 2008;4(11):580-588. PMID: 18852718
  27. Bolek-Berquist J, Elliott ME, Gangnon RE, Gemar D, Engelke J, Lawrence SJ, Hansen KE: Use of a questionnaire to assess vitamin D status in young adults. Public Health Nutr 2009;12(2):236-243. NIHMSID 198051, PMC2865138
  28. Kiehn KA, Mahoney J, Jones AN, Hansen KE: Vitamin D Supplement Intake in Elderly Fallers. J Am Geriatr Soc 2009;57(1):176-177. NIHMSID 198050, PMC2865134
  29. Hansen KE: Reply, Optimal Vitamin D Status. J Bone Miner Res 2009 24(4):756. Policy Exempt – not a peer-reviewed article.
  30. Penniston KL, Jones AN, Nakada SY, Hansen KE: Vitamin D repletion does not alter urinary calcium excretion in postmenopausal women. BJU Int 2009 April 15. NIHMSID 139007, PMC2783535
  31. Hansen KE: Osteoimmunology: prevalence of hypovitaminosis D and relationship to fracture. Invited editorial Nat Rev Rheumatol 2009;5(8):417-418. Policy exempt – not a peer-reviewed article.
  32. 32. Jones AN, Hansen KE: Recognizing the musculoskeletal manifestations of vitamin D deficiency. J Musculoskel Med 2009;26(10):389-396. NIHMSID 266203, PMC3188408
  33. Kramm HE, Gangnon RE, Jones AN, Linzer M, Hansen KE: The effect of physician workload on an educational intervention to increase vitamin D screening. WMJ 2010;109(3):136-141. NIHMSID 202488, PMC2915451
  34. Jones AN, Blank RD, Lindstrom MJ, Penniston KL, Hansen KE: Adjustment for body mass index and calcitrophic hormone levels improves the diagnostic accuracy of the spot urine calcium-to-creatinine ratio. Osteoporos Int 2010;21(8):1417-1425. NIHMSID 266809; PMC3065296
  35. Jones AN, Hansen KE. A Moratorium on the Spot Urine Calcium-to-Creatinine Ratio. Urology. 2010 Oct;76(4):1021-2. NIHMSID 225354, PMC2966029
  36. Hansen KE, Jones AN, Davis L, Lindstrom MJ, Davis LA, Ziegler T, Penniston KL, Shafer MM: Does Proton Pump Inhibitor Therapy Decrease Calcium Absorption? J Bone Miner Res 2010;25(12):2786-2795. PMID 20578215, PMCID: PMC278353
  37. Since promotion to Associate Professor in 2011:

  38. Hansen KE: High-Dose Vitamin D: Helpful or Harmful? Invited editorial, Curr Rheumatol Rep 2011 Jun;13(3)257-64. NIHMSID 280663, PMC3093446
  39. Shapses SA, Kendler D, Robson R, Hansen KE, Sherrell R, Field P, Woolf E, Berd Y, Mantz AM, Santora A: Effect of alendronate and vitamin D3 on fractional calcium absorption in a double-blind, randomized, placebo-controlled trial in postmenopausal osteoporotic women. J Bone Miner Res, 2011 Aug;26(8):1836-44. Policy Exempt- not sponsored by NIH
  40. Hansen KE, Wilson HA, Zapalowski C, Fink HA, Minisola S, Adler RA: Uncertainties in the prevention and treatment of glucocorticoid-induced osteoporosis. J Bone Miner Res, 2011 Sept;26(9):1989-96. Policy exempt- editorial.
  41. Nansera D, Graziano FM, Freedman DJ, Bobbs MK, Jones AN, Hansen KE: Vitamin D and calcium levels in Ugandan adults with human immunodeficiency virus and tuberculosis. Int J Tubercul Lung Dis 2011 Nov;15(11):1522-7. NIHMSID 359277 PMC3338981
  42. Jones AN, Shafer MM, Keuler NS, Crone EM, Hansen KE: Fasting and post-prandial spot urine calcium-to-creatinine ratios do not diagnose hypercalciuria. Osteoporosis Int 2012;23(2): 553-562. NIHMSID 358325, PMC3295234
  43. Tevaarwerk A, Burkard ME, Wisinski KB, Shafer MM, Davis LA, Gogineni J, Crone EM, Hansen KE: Aromatase inhibitors and calcium absorption in early stage breast cancer. Breast Cancer Res Treat 2012 Jul;134(1):245-251. NIHMSID 359278, PMC3376688
  44. Bartels CM, Saucier JM, Thorpe CT, Kind AJ, Pandhi N, Hansen KE, Smith MA: Monitoring diabetes in patients with and without rheumatoid arthritis: a Medicare study. Arthritis Res Ther 2012; 14(4): R166. PMC3580560
  45. Swenson ED, Hansen KE, Jones AN, Li Z, Baltz-Ward B, Schuna AA, Elliot ME: Characteristics associated with bone mineral density responses to alendronate in men. Calcified Tissue International 2013 Jun;92(6):548-56. NIHMSID 716746
  46. Nabak A, Johnson RE, Keuler NS, Hansen KE: Can a questionnaire predict vitamin D status in postmenopausal women? Public Health Nutr 2014 Apr 17(4)739-746. NIHMSID 564133, PMC3976225
  47. Ramsubiek K, Keuler NS, Davis LA, Hansen KE: Factors associated with calcium absorption in postmenopausal women: A post-hoc analysis of dual isotope studies. J Acad Nutr Diet 2014 May; 114(5)761-767. NIHMSID 5115406, PMC3989396
  48. Ney DN, Blank RD, Hansen KE: Advances in the nutritional and pharmacological management of phenylketonuria. Curr Op Clin Nutr 2014 Jan;17(1):61-68. PMID 24136088
  49. Hansen KE, Nabak AC, Johnson RE, Marvdashti S, Keuler NS, Shafer MM; Abrams SA: Isotope concentrations from 24-h urine and a 3-h serum sample can be used to measure intestinal magnesium absorption in postmenopausal women. J Nutr 2014;144(4):533-537. NIHMSID 564149, PMC3952625
  50. Hansen KE, Bartels CM, Gangnon RE, Jones AN, Gogineni J: An evaluation of high-dose vitamin D for rheumatoid arthritis. J Clin Rheum 2014 Mar;20(2);112-114. NIHMSID 598312, PMC4089514
  51. Hansen KE, Kleker B, Safdar N, Bartels CM: A systematic review and meta-analysis of glucocorticoid induced osteoporosis in children. Semin Arthritis Rheum 2014 Aug; 44(1): 47-54. NIHMSID 567807, PMC4119832
  52. Hansen KE, Blank RD, Jones AN, Palermo L, Fink H, Orwoll E: What Analytic Method Should Clinicians Use to Derive Spine T-scores and Predict Incident Fractures in Men? Results from the MrOS study. Osteoporosis Int 2014 Sept;25(9):2181-8. NIHMSID 598369, PMC4134992
  53. Hansen KE, Ney DN: A systematic review of bone mineral density and fractures in phenylketonuria. Journal of Inherited Metabolic Disease 2014 Nov;37(6):875-80. NIHMSID 612050, PMC4208974
  54. Hui SK, Arentsen L, Sueblinvong T, Brown K, Bolan P, Ghebre RG, Downs L, Shanley R, Hansen KE, Minenko AG, Takhashi Y, Yagi M, Zhang Y, Geller M, Reynolds M, Lee CK, Blaes AH, Allen S, Zobel BB, Le C, Froelich J, Rosen C, Yee D: A phase 1 feasibility study of multi-modality imaging assessing rapid expansion of marrow fat and decreased bone mineral density in cancer patients. Bone 2015 April 73: 90-97.
  55. Hansen KE, Johnson RE, Chambers KR, Johnson MG, Lemon CC, Vo TNT, Marvdashti S: A randomized, double-blind, placebo-controlled clinical trial on the treatment of vitamin D insufficiency in postmenopausal women. JAMA-IM published on line August 3, 2015; doi:10.1001/jamainternmed.2015.3874. NIHMSID 717490
  56. Vreede AP, Jones AN, Hansen KE: Can serum isotope levels accurately measure intestinal calcium absorption compared to gold-standard methods? Nutrition Journal 2015;14:73 doi:10.1186/s12937-015-0065-5. NIHMSID submitted 8.20.15
  57. Bartels CM, Roberts TJ, Hansen KE, Jacobs EA, Gilmore A, Maxcy C, Bowers BJ: Rheumatologist and primary care management of cardiovascular disease risk in rheumatoid arthritis: patient and provider perspectives. Accepted to Arthritis Care & Research 8.4.15