Hematti Lab Research

Basic Research

Mesenchymal Stromal/Stem Cells
• Multipotent, adult cells
• Differentiate into adipocytes, chondrocytes, and osteoblasts
• Found in many tissues of the body

Transplant Biology
• MSCs suppress immune responses
• Have been investigated for treatment of graft versus host disease due to hematopoietic stem cell transplantation
Graft Versus Host Disease
• A major complication after hematopoietic stem cell transplantation due to the newly transplanted immune cells attacking the recipient tissues
• Acute GVHD is primarily a T cell-mediated process
Immune Modulation
• MSCs modulate immune responses through interactions with different immune cells
• We are examining the immune modulatory properties of mesenchymal stem cells
• We have described a novel type of human macrophages generated in vitro after co-culture with MSCs that assume an immunophenotype defined as IL-10 high, IL-12 low, IL-6 high and TNF-alpha low secreting cells
• These MSC-educated macrophages may be a unique and novel type of alternatively activated macrophages with a potentially significant role in tissue repair
Tissue Regeneration
• MSCs seem to preferentially home to sites of injury, where they support functional recovery
• MSCs exert these functions through paracrine effects, such as secretion of cytokines and growth factors
Tissue Engineering
• Interaction of MSCs with scaffolds and extracellular matrix components
Cancer Biology
• Cancer cells reside in a complex microenvironment
• Examining the role of mesenchymal stem cells and macrophages on the growth of tumor cells specifically multiple myeloma cells

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