University of Wisconsin
School of Medicine and Public Health

Dr Halberg's Publications

Search for Richard Halberg's literature abstracts on PubMed

Selected publications:

  1. Pooler BD, Lubner MG, Theis JR, Halberg RB, Liang Z, Pickhardt PJ. Volumetric Textural Analysis of Colorectal Masses at CT Colonography: Differentiating Benign versus Malignant Pathology and Comparison with Human Reader Performance. Acad Radiol. 2018 Mar 19. pii: S1076-6332(18)30114-4. PubMed Listing
  2. Wegner KA, Cadena MT, Trevena R, Turco AE, Gottschalk A, Halberg RB, Guo J, McMahon JA, McMahon AP, Vezina CM. An immunohistochemical identification key for cell types in adult mouse prostatic and urethral tissue sections. PLoS One. 2017 Nov 16;12(11):e0188413. Free PMC Article
  3. Sievers CK, Grady WM, Halberg RB, Pickhardt PJ. New insights into the earliest stages of colorectal tumorigenesis. Expert Rev Gastroenterol Hepatol. 2017 Aug;11(8):723-729. Free PMC Article

  4. Sievers CK, Zou LS, Pickhardt PJ, Matkowskyj KA, Albrecht DM, Clipson L, Bacher JW, Pooler BD, Moawad FJ, Cash BD, Reichelderfer M, Vo TN, Newton MA, Larget BR, Halberg RB. Subclonal diversity arises early even in small colorectal tumours and contributes to differential growth fates. Gut. 2017 66(12):2132-2140. Free PMC Article

  5. Sievers CK, Leystra AA, Clipson L, Dove WF, Halberg RB. Understanding intratumoral heterogeneity: lessons from the sequence analysis of at-risk tissue and premalignant lesions in the colon. Cancer Prev Res (Phila) 2016; 9(8):638-41. Free PMC Article

  6. Bauman TM, Vezina CM, Ricke EA, Halberg RB, Huang W, Peterson RE, Ricke WA. Expression and colocalization of beta-catenin and lymphoid enhancing factor-1 in prostate cancer progression. Hum Pathol 2016; 51:124-33. Free PMC Article

  7. Hadac JN, Miller DD, Grimes IC, Clipson L, Newton MA, Schelman WR, Halberg RB. Heterochromatin Protein 1 Binding Protein 3 Expression as a Candidate Marker of Intrinsic 5-Fluorouracil Resistance. Anticancer Res 2016; 36(3):845-52. Free PMC Article

  8. Zahm CD, Szulczewski JM, Leystra AA, Paul Olson TJ, Clipson L, Albrecht DM, Middlebrooks M, Thliveris AT, Matkowskyj KA, Washington MK, Newton MA, Eliceiri KW, Halberg RB. Advanced Intestinal Cancers often Maintain a Multi-Ancestral Architecture. PLoS One 2016; 11(2):e0150170. Free PMC Article

  9. Hadac JN, Leystra AA, Paul Olson TJ, Maher ME, Payne SN, Yueh AE, Schwartz AR, Albrecht DM, Clipson L, Pasch CA, Matkowskyj KA, Halberg RB, Deming DA. Colon Tumors with the Simultaneous Induction of Driver Mutations in APC, KRAS, and PIK3CA Still Progress through the Adenoma-to-carcinoma Sequence. Cancer Prev Res (Phila) 2015; 8(10):952-61. Free PMC Article

  10. Bacher JW, Sievers CK, Albrecht DM, Grimes IC, Weiss JM, Matkowskyj KA, Agni RM, Vyazunova I, Clipson L, Storts DR, Thliveris AT, Halberg RB. Improved Detection of Microsatellite Instability in Early Colorectal Lesions. PLoS One. 2015 Aug 7;10(8):e0132727. Free Article

  11. Lubner MG, Stabo N, Lubner SJ, Del Rio AM, Song C, Halberg RB, Pickhardt PJ. CT textural analysis of hepatic metastatic colorectal cancer: pre-treatment tumor heterogeneity correlates with pathology and clinical outcomes. Abdom Imaging. 2015 May 13.

  12. Deming DA, Maher ME, Leystra AA, Grudzinski JP, Clipson L, Albrecht DM, Washington MK, Matkowskyj KA, Hall LT, Lubner SJ, Weichert JP, Halberg RB. Phospholipid ether analogs for the detection of colorectal tumors. PLoS One. 2014 Oct 6;9(10):e109668. Free PMC Article

  13. Robins HI, Burkard ME, Halberg RB. "TRIMing" the patient population to increase the benefit of mTOR inhibition. J Natl Cancer Inst. 2014 Apr 28;106(5). pii: dju095. Free Article

  14. Dove WF, Shedlovsky A, Clipson L, Amos-Landgraf JM, Halberg RB, Krentz KJ, Boehm FJ, Newton MA, Adams DJ, Keane TM. A strategy to identify dominant point mutant modifiers of a quantitative trait. Cancer Prev Res (Phila). 2014 Jan;7(1):105-13. Free PMC Article

  15. Paul Olson TJ, Hadac JN, Sievers CK, Leystra AA, Deming DA, Zahm CD, Albrecht DM, Nomura A, Nettekoven LA, Plesh LK, Clipson L, Sullivan R, Newton MA, Schelman WR, Halberg RB. Dynamic tumor growth patterns in a novel murine model of colorectal cancer.  Cancer Prev Res (Phila). 2014 Jan;7(1):105-13. Free PMC Article

  16. Thliveris AT, Schwefel B, Clipson L, Plesh L, Zahm CD, Leystra AA, Washington MK, Sullivan R, Deming DA, Newton MA, Halberg RB. Transformation of Epithelial Cells through Recruitment Leads to Polyclonal Intestinal Tumors. PNAS, 2013 July; 110(28):11523-11. Free PMC Article

  17. Deming DA, Leystra AA, Nettekoven L, Sievers C, Miller D, Middlebrooks M, Clipson L, Albrecht DM, Bacher J, Washington MK, Weichert JP, Halberg RB. PIK3CA and APC mutations are synergistic in the development of intestinal cancers. Oncogene. 2014 Apr 24;33(17):2245-54. Free PMC Article

  18. Deming DA, Leystra AA, Farhoud M, Nettekoven LA, Clipson L, Albrecht DM, Washington MK, Sullivan R, Weichert JP, Halberg RB. mTOR inhibition elicits a dramatic repsonse in PI3K-dependent colon cancers. PLOS One, 2013 April; 8(4):e60709. Free PMC Article

  19. Leystra AA, Deming DA, Zahm CD, Farhoud M, Paul Olson TJ, Hadac JN, Nettekoven LA, Albrecht DM, Clipson L, Sullivan R, Washington MK, Torrealba JR, Weichert JP, Halberg RB. Mice expressing activated PI3K develop advanced colon cancer. Cancer Res, 2012 June; 72(12):2931-36. Free PMC Article

  20. Irving AA, Halberg RB, Albrecht DM, Plum LA, Krentz KJ, Clipson L, Drinkwater N, Amos-Landgraf JM, Dove WF, DeLuca HF. Supplementation by vitamin D compounds does not affect colonic tumor development in vitamin D sufficient murine models. Arch Biochem Biophys. 2011 Nov; 515(1-2):64-71. Free PMC Article

  21. Thliveris AT, Clipson L, White A, Waggoner J, Plesh L, Skinner B L, Zahm CD, Sullivan R, Dove WF, Newton MA, Halberg RB. Clonal structure of carcinogen-induced intestinal tumors in mice. Cancer Prev Res (Phila). 2011 Jun;4(6):916-23. Free PMC Article

  22. Spier BJ, Walker AJ, Cornett DD, Pfau PR, Halberg RB, Said A. Screening colonoscopy and detection of neoplasia in asymptomatic, average-risk, solid organ ransplant recipients: case-control study. Transpl Int. 2010 Dec;23(12):1233-8.

  23. Ji X, Tang J, Halberg R, Busam D, Ferriera S, Peña MM, Venkataramu C, Yeatman TJ, Zhao S. Distinguishing between cancer driver and passenger gene alteration candidates via cross-species comparison: a pilot study. BMC Cancer. 2010 Aug 13;10:426. Free PMC Article

  24. Durkee BY, Shinki K, Newton MA, Iverson C, Weichert J, Dove WF, Halberg RB. Longitudinal assessment of colonic tumor fate in mice by computed tomography and optical colonoscopy. Academic Radiology 16:1475-82, 2009. Free PMC Article

  25. Huttlin EL, Chen X, Barrett-Wilt GA, Hegeman AD, Halberg RB, Harms AC, Newton MA, Dove WF, Sussman MR. Discovery and validation of colonic tumor-associated proteins via metabolic labeling and stable isotopic dilution. Proc Natl Acad Sci U S A 106:17235-40, 2009. Free PMC Article

  26. Durkee BY, Weichert JP, Halberg RB. Small animal microCT colonography.Methods. 2010 Jan;50(1):36-41. Free PMC Article

  27. Halberg RB, Waggoner J, Rasmussen, White A, Clipson L, Prunuske AJ, Bacher JW, Sullivan R, Washington MK, Pitot HC, Petrini JHJ, Albertson DG, Dove WF. Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway. Cancer Research 69:5768-575, 2009. Free PMC Article

  28. Halberg RB, Campaign Larsen M, Elmergreen TL, Ko AY, Irving AA, Clipson L, Jefcoate CR. Cyp1b1 exerts opposing effects on intestinal tumorigenesis via exogenous and endogenous substrates. Cancer Research 68:7394-7402, 2008. Open access. Free PMC Article

  29. Halberg RB, Chen X, Amos-Landgraf JM, White A, Rasmussen K, Clipson L, Pasch C, Sullivan R, Pitot HC, Dove WF. The pleiotropic phenotype of Apc mutations in the mouse - allele specificity and effects of the genetic background. Genetics 180:601-609, 2008. Open access. Free PMC Article

  30. Chen X, Halberg RB, Burch RP, Dove WF. Intestinal adenomagenesis involves core molecular signatures of the epithelial-mesenchymal transition. Journal of Molecular Histology 39:283-294, 2008. Free PMC Article

  31. Durkee BY, Mudd SR, Roen CN, Clipson L, Newton MA, Weichert JP, Pickhardt PJ, Halberg RB. Reproducibility of tumor volume measurement at microCT colonography in living mice. Academic Radiology 15:334-341, 2008. Free PMC Article

  32. Chen X, Ehrhardt WM, Halberg RB, Aronow BJ. Dove WF. Cellular expression patterns of genes upregulated in murine and human colonic neoplasms. Journal of Histochemistry and Cytochemistry 56:433-441, 2008. Free PMC Article

  33. Dove WF, Amos-Landgraf JM, Chen X, Kwong LN, Clipson L, Halberg RB. Basic and applied issues in colon cancer studied in the Min mouse and Pirc rat kindreds. In: Extended Abstracts for the 38th International Symposium of the Princess Takamatsu Cancer Research Fund: Current Challenges in the Understanding and Management of Colon Cancer. Edited by Nakagama H, Dove WF, Mori H, Wakabayashi K. 2007. [PDF]

  34. Kaiser S, Park YK, Franklin JL, Halberg RB, Yu M, Jessen WJ, Freudenberg J, Chen X, Haigis K, Jegga AG, Kong S, Sakthivel B, Xu H, Reichling T, Azhar M, Boivin GP, Roberts RB, Bissahoyo AC, Gonzales F, Bloom GC, Eschrich S, Carter SL, Aronow JE, Kleimeyer J, Kleimeyer M, Ramaswamy V, Settle SH, Boone B, Levy S, Graff JM, Doetschman T, Groden J, Dove WF, Threadgill DW, Yeatman TJ, Coffey RJ Jr, Aronow BJ. Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biology 8:R131, 2007. Free PMC Article

  35. Halberg RB and Dove WF. Polyclonal tumors in the mammalian intestine: Are interactions among multiple initiated clones necessary for tumor initiation, growth, and progression? Cell Cycle 6:44-51, 2007. Free PMC Article

  36. Leedham SJ, Thliveris AT, Halberg RB, Newton MA & Wright NA. Gastrointestinal stem cells and cancer: bridging the molecular gap. Stem Cell Reviews 1:233-241, 2005.

  37. Megid WA, Ensenberger MG, Halberg RB, Stanhope SA, Kent-First MG, Prolla TA, Bacher JW. A novel method for biodosimetry. Radiat Environ Biophys 46:147-54, 2007

  38. Newton MA, Clipson L, Thliveris AT, Halberg RB. A statistical test of the hypothesis that polyclonal intestinal tumors arise by random collision of initiated clones. Biometrics. 62:721-7, 2006

  39. Leedham SJ, Schier S, Thliveris AT, Halberg RB, Newton MA & Wright NA. From gene mutations to tumours - stem cells in gastrointestinal carcinogenesis. Cell Prolif. 38:387-405, 2005.

  40. Bacher JW, Abdel Megid WM, Kent-First MG, Halberg RB. Use of mononucleotide repeat markers for detection of microsatellite instability in mouse tumors. Mol Carcinog. 44:285-92, 2005

  41. Thliveris AT, Halberg RB, Clipson L, Dove WF, Sullivan R, Washington MK, Stanhope S, Newton MA. Polyclonality of familial murine adenomas: Analyses of mouse chimeras with low tumor multiplicity suggest short-range interactions. Proc. Natl. Acad. Sci. U.S.A. 102: 6960-6965, 2005. Open access. Free PMC Article

  42. Pickhardt PJ, Halberg RB, Taylor AJ, Durkee BY, Fine J, Lee FT Jr, Weichert JP. Microcomputed tomography colonography for polyp detection in an in vivo mouse tumor model. Proc. Natl. Acad. Sci. U.S.A. 102: 3419-3422, 2005. Free PMC Article

  43. Bacher JW, Flanagan LA, Smalley RL, Nassif NA, Burgart LJ, Halberg RB, Megid WM, Thibodeau SN. Development of a fluorescent multiplex assay for detection of MSI-High tumors. Dis Markers 20:237-50, 2004. Free PMC Article

  44. Haigis KM, Hoff PD, White A, Shoemaker AR, Halberg RB, Dove WF. Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function. Proc. Natl. Acad. Sci. U.S.A. 101: 9769-73, 2004. Open access. Free PMC Article

  45. Chen X, Halberg RB, Ehrhardt WM, Torrealba J, Dove WF. Clusterin as a biomarker in murine and human intestinal neoplasia. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9530-5. Free PMC Article

  46. Boivin GP, Washington K, Yang K, Ward JM, Pretlow TP, Russell R, Besselsen DG, Godfrey VL, Doetschman T, Dove WF, Pitot HC, Halberg RB, Itzkowitz SH, Groden J, Coffey RJ. Pathology of mouse models of intestinal cancer: consensus report and recommendations. Gastroenterology. 2003 Mar;124(3):762-77.

  47. Cormier RT, Bilger A, Lillich AJ, Halberg RB, Hong KH, Gould KA, Borenstein N, Lander ES, Dove WF. The Mom1AKR intestinal tumor resistance region consists of Pla2g2a and a locus distal to D4Mit64. Oncogene. 2000 Jun 29;19(28):3182-92. Free Article

  48. Halberg RB, Katzung DS, Hoff PD, Moser AR, Cole CE, Lubet RA, Donehower LA, Jacoby RF, Dove WF. Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3461-6. Free PMC Article

  49. Dove WF, Cormier RT, Gould KA, Halberg RB, Merritt AJ, Newton MA, Shoemaker AR. The intestinal epithelium and its neoplasms: genetic, cellular and tissue interactions. Philos Trans R Soc Lond B Biol Sci. 1998 Jun 29;353(1370):915-23. Free PMC Article

  50. Cormier RT, Hong KH, Halberg RB, Hawkins TL, Richardson P, Mulherkar R, Dove WF, Lander ES. Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis. Nat Genet. 1997 Sep;17(1):88-91.