Nephrology Research

The section of Nephrology has a number of ongoing research studies in many aspects of kidney disease, including clinical research, translational research, and basic science. One of the clinical objectives of the section is to gauge the effect of treatments and intervention in patients with acute renal failure, chronic kidney disease, and kidney transplantation. The current focus of translational research is the study of oxidative stress in development and progression of chronic allograft nephropathy and chronic kidney disease. The basic science research program includes studies of the regulation of matrix metalloproteinases in glomerular mesangial and tubular epithelial cells, and their role in epithelial-to-mesenchymal transition, immunomodulatory roles of vitamin D and angiotensin receptor blockers, the role of smad proteins (TGF-β pathway) in kidney disease progression, the role of oxidative stress and small heat shock protein 27 (HSP27) in kidney disease progression, and mechanisms of B-lymphocyte and antibody-mediated allograft injury.