Dr. Alexey Glukhov graduated in Biophysics from the Moscow Institute of Physics and Technology, Russia, in 2003. He then moved to the laboratory of cardiac electrophysiology, Cardiology Research Centre, Moscow, to undertake a PhD studying the electrophysiological mechanisms of natural resistance of hibernating animals to ventricular arrhythmias associated with hypothermia and/or ischemia. After completing PhD, Dr. Glukhov has been trained at Washington University in Saint Louis, USA, and at the Ohio State University, USA, pursuing research at the interface between cardiac physiology/cell biology and biomedical engineering. In 2012, Alexey joined the laboratory of functional microscopy at Imperial College London, United Kingdom. He is currently an Assistant Professor in the Department of Medicine. Dr. Glukhov’s research focuses on understanding the multicellular mechanisms involved in cardiac remodeling following heart failure and atrial fibrillation among multiple levels of cardiac signaling: from protein expression, phosphorylation, and sub-cellular localization, protein-protein interaction, to propagation and repolarization of an intact heart. His research combines several state-of-the-art techniques, including high-resolution fluorescent optical mapping and scanning ion conductance microscopy (SICM) equipped with “smart” patch-clamp. These are applied to investigate sub-cellular compartmentalization of ion channels and regulatory G-protein coupled receptors and their roles in atrial and ventricular arrhythmogenesis/dysfunction associated with different pathologies.
Miragoli M, Glukhov AV. Atrial fibrillation and fibrosis: Beyond the cardiomyocyte centric view. BioMed Research International. 2015. In press.
Glukhov AV, Kalyanasundaram A, Lou Q, Hage LT, Hansen BJ, Belevych AE, Mohler PJ, Knollmann BC, Periasamy M, Györke S, Fedorov VV. Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex. Eur Heart J. 2015, 36(11): 686-97.
Balycheva M, Faggian G, Glukhov AV, Gorelik J. Microdomain–specific localization of functional ion channels in cardiomyocytes: An emerging concept of local regulation and remodelling. Biophysical Reviews. 2015; 7(1): 43-62.
Glukhov AV, Hage LT, Hansen BJ, Pedraza-Toscano A, Vargas-Pinto P, Hamlin RL, Weiss R, Carnes CA, Billman GE, Fedorov VV. Sinoatrial node reentry in a canine chronic left ventricular infarct model: role of intranodal fibrosis and heterogeneity of refractoriness. Circ Arrhythm Electrophysiol. 2013, 6(5):984-94.
Glukhov AV, Fedorov VV, Kalish PW, Ravikumar VK, Lou Q, Janks D, Schuessler RB, Moazami N, Efimov IR. Mechanisms underlying electrophysiological substrate for arrhythmia in human non-ischemic end-stage cardiomyopathic ventricles. Circulation. 2012;125:1835-1847
Fedorov VV, Glukhov AV, Chang R. Conduction barriers and pathways of the sino-atrial pacemaker complex: their role in normal rhythm and atrial arrhythmias. Am J Physiol Heart Circ Physiol. 2012 May; 302(9):H1773-83.
Lang D, Glukhov AV, Efimova T, Efimov IR. The role of Pyk2 in cardiac arrhythmogenesis. Am J Physiol Heart Circ Physiol. 2011 Sep; 301(3):H975-83.
Glukhov AV, Fedorov VV, Mohler PJ, Anderson ME, Efimov IR. Functional anatomy of the murine sinus node: Evidence from high-resolution optical mapping. Am J Physiol Heart Circ Physiol. 2010: 299(2): H482-91.
Glukhov AV, Fedorov VV, Lou Q, Ravikumar VK, Kalish PW, Schuessler RB, Moazami N, Efimov IR. Transmural dispersion of repolarization in failing and non-failing human ventricle. Circ Res. 2010; 106(5):981-91.
Glukhov AV, Flagg TP, Fedorov VV, Efimov IR, Nichols CG. Differential KATP channel pharmacology in intact mouse heart. J Moll Cell Cardiol, 2009, 48(1):152-60.