Contact Information

Photo of Sanjay Asthana
Sanjay Asthana, MD

PROFESSOR

GERIATRICS

2870 UNIVERSITY AVE
MADISON, WI 53705-3611

(608) 265-5862




Biography

Current Appointments

Duncan G. and Lottie H. Ballantine Chair in Geriatrics
Head, Division of Geriatrics and Gerontology
Department of Medicine
University of Wisconsin School of Medicine
Madison, WI 53705 U.S.A.

Director
NIA/NIH, Wisconsin-Alzheimer's Disease Research Center (ADRC)
University of Wisconsin-Madison School of Medicine and Public Health
Madison, WI 53705 U.S.A.

Director
Geriatric Research, Education and Clinical Center (GRECC)
William S. Middleton Memorial Veterans Hospital
Madison, WI 53705 U.S.A.

Education

GRADUATE

July 1973 - March 1978 University College of Medical Sciences

University of Delhi, New Delhi, India


April 1980 MB; BS

RESIDENCY

July 1987 - June 1988 Third year Senior Resident, Department of Medicine

University of Saskatchewan School of Medicine

Saskatoon, Canada S7N-OXO.


July 1988 - June 1989 Chief Resident (4th year)

Department of Internal Medicine

University of Saskatchewan School of Medicine

Saskatoon, Canada S7N-OXO.

FELLOWSHIPS

August 1989 - June 1992 Clinical Research Fellow

Division of Geriatric Medicine and Gerontology

The Johns Hopkins University School of Medicine

Baltimore, MD 21224, U.S.A.


February 1990 - Sep. 1990 Guest Researcher

Laboratory of Neurosciences

National Institute on Aging

National Institutes of Health (NIH)

Bethesda, MD 20892, U.S.A.


October 1990 - Sep. 1992 Fogarty Staff Fellow

Laboratory of Neurosciences

National Institute on Aging, NIH

Bethesda, MD 20892, U.S.A.


September 1992 - July 1993 Senior Staff Fellow

Laboratory of Neurosciences

National Institute on Aging, NIH

Bethesda, MD 20892, U.S.A.

Research Interests

Clinical psychopharmacology and neuroendocrinology of gonadal steroids and cholinergic drugs in Alzheimer's disease and healthy aging

  1. Cognitive and neuroendocrine effects of estrogen and testosterone administration in Alzheimer's disease and healthy aging.
  2. Potential beneficial effects of estrogen and testosterone treatment on performance-based measures of independent living skills for healthy older adults as well as those with Alzheimer's disease.
  3. Identification of biological markers for therapeutic responsivity to estrogen for women with Alzheimer's disease.
  4. Evaluation of therapeutic efficacy of raloxifene, a selective estrogen receptor modulator (SERM), in subjects with Alzheimer's disease.
  5. Cholinergic drugs: Clinical psychopharmacology studies in Alzheimer's disease.
  6. Clinical pharmacokinetics and neuroendocrinology of cholinergic drugs in subjects with AD.

Search for Sanjay Asthana's literature abstracts on PubMed

SELECTED PUBLICATIONS

Baker LD, Asthana S, Cholerton BA, Wilkinson CW, Plymate SR, Green PS, Merriam GR, Fishel MA, Watson GS, Cherrier MM, Kletke ML, Mehta PD, Craft S: Cognitive response to estradiol in postmenopausal women is modified by high cortisol. Neurobiol of Aging, 33(4):829, e9-20, April, 2012. PMID:21855173, PMCID:PMC3302351

Wharton W, Baker LD, Gleason CE, Dowling M, Barnet JH, Johnson S, Carlsson C, Craft S, Asthana S: Short-term hormone therapy with transdermal estradiol improves cognition for postmenopausal women with Alzheimer's disease: results of a randomized controlled trial. J Alzheimer's Dis, 26(3):495-505, 2011. PMID:21694454, PMCID:PMC3302351.

Gleason CE, Dowling NM, Friedman E, Wharton W, Asthana S: Using predictors of hormone therapy use to model healthy user bias: how does healthy user status influence cognitive effects of hormone therapy? Menopause, December, 2011 [Epub ahead of print]. PMID:22207317, NIHMS333890.

Johnson SC, La Rue A, Hermann BP, Xu G, Koscik RL, Jonaitis EM, Bendlin BB, Hogan KJ, Roses AD, Saunders AM, Lutz MW, Asthana S, Green RC, Sager MA: The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE e3/e3 genotype. Alzheimer's and Dementia, 7(4):456-465, July, 2011. PMID:21784354, PMCID:PMC3143375.
Xu G, Mclaren DG, Ries ML, Fitzgerald ME, Bendlin BB, Rowley HA, Sager MA, Atwood C, Asthana S, Johnson SC: The influence of parental history of Alzheimer's disease and apolipoprotein E epsilon4 on the BOLD signal during recognition memory. Brain, 132(2):383-391, 2009. PMCID:PMC2724919.

Bendlin BB, Ries ML, Canu E, Sodhi A, Lazar M, Alexander AL, Carlsson CM, Sager MA, Asthana S, Johnson SC: White matter is altered with parental family history of Alzheimer's disease. Alzheimer's & Dementia, vol 6(5):394-403, September, 2010. PMCID:PMC2933285.