600 HIGHLAND AVE
MADISON, WI 53792-0001
Specialty: Pulmonary and Critical Care Medicine
Board Certification(s): Internal Medicine; Pulmonary; Critical Care
Medical School: University of Minnesota - Minneapolis
Residency: University of Chicago
Fellowship: University of Chicago
Primary Affiliation(s): UW Hospital and Clinics
I am interested in the diagnosis and management of interstitial lung diseases (ILDs), such as idiopathic pulmonary fibrosis. I currently maintain an active clinic, focusing on ILD and currently interface with the interstitial lung disease group at the University of Wisconsin. I also have a strong clinical focus on the pathophysiology of critical illness, and work as a critical care service attending in the Trauma and Life Support Center (TLC) and Neuroscience Intensive Care Unit (NeuroICU).
I currently maintain an active laboratory based research program, focusing on fibroblast biology and signaling in the context of tissue remodeling and pulmonary fibrosis. I am interested in the interaction between cell shape/cytoskeletal reorganization and associated downstream intracellular signaling/transcriptional regulation in this context. Elucidation of these signaling pathways has implications for the cross-talk between mechanical stimuli and traditional soluble and paracrine mediators of fibroblast activation (TGF-beta, G-protein coupled receptor agonists, etc).
Current areas of focus include: 1) elucidation of the role of the actin and microtubule cytoskeleton in mediating TGF-beta induced myofibroblast differentiation; 2) examination of the role of serum response factor in the transcriptional regulation of critical genes mediating myofibroblast differentiation; 3) the regulatory role of signaling via Protein Kinase A on SRF in this context; 4) the role of MRTF-A/SRF expression and activity during in vivo fibrogenesis, and 5) the investigation of novel SRF-dependent genes involved in fibrogenesis.
Search for Nathan Sandbo's literature abstracts on PubMed