Ongoing Clinical Trials

Title PI Name Status
Brain Alterations And Cognitive Impairment in Older Adults with Heart Failure Bratzke, Lisa Open to Enrollment
Secret of CHF: Randomized, Double-Blind, Placebo Controlled Study of the Short Term Clinical Effects of Tolvaptan in Patients Hospitalized for Worsening Heart Failure with Challenging Volume Management Dhingra, Ravi Open to Enrollment
PARAGON: A Multicenter, Randomized, Double-Blind, Parallel Group, Active-Controlled Study to Evaluate the Efficacy and Safety of LCZ696 Compared to Valsartan on Morbidity and Mortality in Heart Failure Patients (NYHA Class II-IV) with Preserved Ejection Fraction Dhingra, Ravi Open to Enrollment
CREST:  The Cardiovascular Effects of Sunitinib Therapy:  Off-Target Changes in Cardiac Metabolism and Ventricular-Vascular Mechanics Ewer, Steven Open to Enrollment
PARTNER II:  Placement of AoRTic TraNscathetER Valves Trial II The Safety and Effectiveness of the SAPIEN XT? Transcatheter Heart Valve with delivery systems in Intermediate and High Risk for Aortic Valve Surgery and Patients Who Cannot Undergo Surgery Gimelli, Giorgio Open to Enrollment
REDUCE:  GORE HELEX Septal Occluder and Antiplatelet Medical Management for Reduction in Recurrent Stroke or Imaging-Confirmed TIA in patients with Patent Foramen Ovale (PFO)  Gimelli, Giorgio Active; Closed to Enrollment
CIRT:  Cardiovascular Inflammation Reduction Trial (CIRT): A randomized, double-blind, placebo-controlled, event-driven trial of  low-dose methotrexate in the prevention of cardiovascular events among stable CAD patients with type 2DM or metabolic  syndrome Hughes, Patrick Open to Enrollment
CTOT-11: Prevention of Cardiac Allograft Vasculopathy Using Rituximab (Rituxan) Therapy in Cardiac Transplantation Johnson, Maryl, R Active: Closed to Enrollment
Ad5.hAC6 Gene Transfer for CHF Murray, David, R Active: Closed to Enrollment
TEVA:  Double-blind, Randomized, Sham-procedure-controlled, Parallel-group Efficacy and Safety Study of Allogeneic Mesenchymal Precursor Cells (CEP-41750) in Patients with Chronic Heart Failure Murray, David, R Open to Enrollment
COSMIC-HF:  A Double-blind, Randomized, Placebo-controlled, Multicenter, Dose Escalation Study to Select and Evaluate an Oral Modified Release Formulation of Omecamtiv Mecarbil in Subjects with Chronic Heart Failure and Left Ventricular Systolic Dysfunction Rahko, Peter Active; Closed to Enrollment
ixCELL-DCM:  A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy, Safety and Tolerability of Transendocardial Injection of ixmyelocel-T in Subjects with Heart Failure due to Ischemic Dilated Cardiomyopathy (IDCM) Raval, Amish, N Active: Closed to Enrollment
RENEW:  Efficacy and Safety of Targeted Intramyocardial Delivery of Auto CD34+ Stem Cells for Improving Exercise Capacity in Subjects With Refractory Angina Raval, Amish, N Active: Closed to Enrollment
Prochymal® (Human Adult Stem Cells) Intravenous Infusion Following Acute Myocardial Infarction (AMI) Raval, Amish, N Active: Closed to Enrollment
Vaccination to improve Clinical outComes in Heart Failure Trial (VACC-HeFT): a feasibility study Vardeny, Orly Open to Enrollment